Výsledky vyhledávání - "Katwan, Omar J."

Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms

Autor: Mancini, Sarah J., Boyd, Daria, Katwan, Omar J., Strembitska, Anastasiya, Almabrouk, Tarek A., Kennedy, Simon, Palmer, Timothy M., Salt, Ian P.

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports

Recent clinical trials of the hypoglycaemic sodium-glucose co-transporter-2 (SGLT2) inhibitors, which inhibit renal glucose reabsorption, have reported beneficial cardiovascular outcomes. Whether SGLT2 inhibitors directly affect cardiovascular tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::57a9af7c13ac09a670e047be7948f383
https://eprints.gla.ac.uk/158937/7/158937.pdf

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High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion

Autor: Almabrouk, Tarek A.M., White, Anna D., Ugusman, Azizah B., Skiba, Dominik S., Katwan, Omar J., Alganga, Husam, Guzik, Tomasz J., Touyz, Rhian M., Salt, Ian P., Kennedy, Simon

Background and aim: Perivascular adipose tissue (PVAT) positively regulates vascular function through production of factors such as adiponectin but this effect is attenuated in obesity. The enzyme AMP-activated protein kinase (AMPK) is present in PVA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4761a870328f753ed0786d55879b90c4
https://eprints.gla.ac.uk/155451/1/155451.pdf

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Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release

Autor: Almabrouk, Tarek Ali Mohamed, Ugusman, Azizah B., Katwan, Omar J., Salt, Ian P., Kennedy, Simon

Background and Purpose:\ud \ud Perivascular adipose tissue (PVAT) surrounds most blood vessels and secretes numerous active substances, including adiponectin, which produce a net anticontractile effect in healthy individuals. AMPK is a key mediator o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f872883a3aad3cbe873cc3b9906f9f5c
https://eprints.gla.ac.uk/123576/7/123576.pdf

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Changes in IP3 receptor expression and function in aortic smooth muscle of atherosclerotic mice

Autor: Ewart, Marie-Ann, Ugusman, Azizah, Vishwanath, Anisha, Almabrouk, Tarek A.M., Alganga, Husam S.F., Katwan, Omar J., Hubanova, Pavlina, Currie, Susan, Kennedy, Simon

Publikováno v: Journal of Vascular Research

Peroxynitrite is an endothelium-independent vasodilator that induces relaxation via membrane hyperpolarization. The activation of IP3 receptors triggers the opening of potassium channels and hyperpolarization. Previously we found that relaxation to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::533b8213bf513ee4253c63fe5647cd67
https://strathprints.strath.ac.uk/59498/7/Ewart_etal_JVR_2017_Changes_in_IP3_receptor_expression_and_function.pdf

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