Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Katsuyuki Yugi"'
Autor:
Akiko Hashimoto-Tane, Edward P. Bowman, Machie Sakuma, Natsumi Yoneda, Katsuyuki Yugi, Rene de Waal Malefyt, Takashi Saito
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Lymphocyte activation gene (Lag)-3 is an inhibitory co-receptor and target of immune checkpoint inhibitor (ICI) therapy for cancer. The dynamic behavior of Lag-3 was analyzed at the immune synapse upon T-cell activation to elucidate the Lag-3 inhibit
Externí odkaz:
https://doaj.org/article/01488bb5ac8c4a6ab38ab7b584d9ff15
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Biochemical network visualization is one of the essential technologies for mechanistic interpretation of omics data. In particular, recent advances in multi-omics measurement and analysis require the development of visualization methods that
Externí odkaz:
https://doaj.org/article/8b8b1e72d9724f8a83b379ede954e7e5
Autor:
Toshiya Kokaji, Miki Eto, Atsushi Hatano, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Yuki Ito, Riku Egami, Saori Uematsu, Akira Terakawa, Yifei Pan, Hideki Maehara, Dongzi Li, Yunfan Bai, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Hiroyuki Kubota, Yutaka Suzuki, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Metabolic regulation in skeletal muscle is essential for blood glucose homeostasis. Obesity causes insulin resistance in skeletal muscle, leading to hyperglycemia and type 2 diabetes. In this study, we performed multiomic analysis of the ske
Externí odkaz:
https://doaj.org/article/dd5db8b9f47843dbacf9bbaaf001a016
Autor:
Kosuke Miyauchi, Yu Adachi, Keisuke Tonouchi, Taiki Yajima, Yasuyo Harada, Hidehiro Fukuyama, Senka Deno, Yoichiro Iwakura, Akihiko Yoshimura, Hideki Hasegawa, Katsuyuki Yugi, Shin-ichiro Fujii, Osamu Ohara, Yoshimasa Takahashi, Masato Kubo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The reasons why influenza infection promotes a broader antibody response compared with vaccines are not fully understood. Here the authors show that unmasking of haemagglutinin epitopes and IL-4 signals in the germinal centre contribute to broader an
Externí odkaz:
https://doaj.org/article/439271e19f7845d6b2e4d127336088a7
Autor:
Akira Terakawa, Yanhui Hu, Toshiya Kokaji, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Yifei Pan, Yunfan Bai, Andrey A. Parkhitko, Xiaochun Ni, John M. Asara, Martha L. Bulyk, Norbert Perrimon, Shinya Kuroda
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104231- (2022)
Summary: Insulin signaling promotes anabolic metabolism to regulate cell growth through multi-omic interactions. To obtain a comprehensive view of the cellular responses to insulin, we constructed a trans-omic network of insulin action in Drosophila
Externí odkaz:
https://doaj.org/article/2f11eb9ab7944adc856e74542facdc46
Autor:
Riku Egami, Toshiya Kokaji, Atsushi Hatano, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Saori Uematsu, Akira Terakawa, Yunfan Bai, Yifei Pan, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Shinsuke Uda, Hiroyuki Kubota, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102217- (2021)
Summary: Systemic metabolic homeostasis is regulated by inter-organ metabolic cycles involving multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic diseases. The systemic landscape of dysregulated inter-organ metaboli
Externí odkaz:
https://doaj.org/article/16277b1822a647cf9a657d68049c4b26
Autor:
Lake-Ee Quek, James R. Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J. Fazakerley, Richard Scalzo, Sarah D. Elkington, Ziwei Dai, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Jason W. Locasale, Tomoyoshi Soga, David E. James, Shinya Kuroda
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101786- (2020)
Externí odkaz:
https://doaj.org/article/f9326031781b4a06a1113f66a90c237c
Autor:
Daisuke Hoshino, Kentaro Kawata, Katsuyuki Kunida, Atsushi Hatano, Katsuyuki Yugi, Takumi Wada, Masashi Fujii, Takanori Sano, Yuki Ito, Yasuro Furuichi, Yasuko Manabe, Yutaka Suzuki, Nobuharu L. Fujii, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101558- (2020)
Summary: Skeletal muscle adaptation is mediated by cooperative regulation of metabolism, signal transduction, and gene expression. However, the global regulatory mechanism remains unclear. To address this issue, we performed electrical pulse stimulat
Externí odkaz:
https://doaj.org/article/9fb0ce1309754d78a3727d73981942e8
Autor:
Satoshi Ohno, Lake-Ee Quek, James R. Krycer, Katsuyuki Yugi, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Tomoyoshi Soga, David E. James, Shinya Kuroda
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101479- (2020)
Summary: Insulin regulates glucose metabolism through thousands of regulatory mechanisms; however, which regulatory mechanisms are keys to control glucose metabolism remains unknown. Here, we performed kinetic trans-omic analysis by integrating isoto
Externí odkaz:
https://doaj.org/article/5dcee48e0c5d42319ef09140d3fbbe36
Autor:
Kentaro Kawata, Atsushi Hatano, Katsuyuki Yugi, Hiroyuki Kubota, Takanori Sano, Masashi Fujii, Yoko Tomizawa, Toshiya Kokaji, Kaori Y. Tanaka, Shinsuke Uda, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Kaori Saitoh, Keiko Kato, Ayano Ueno, Maki Ohishi, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
iScience, Vol 7, Iss , Pp 212-229 (2018)
Summary: The concentrations of insulin selectively regulate multiple cellular functions. To understand how insulin concentrations are interpreted by cells, we constructed a trans-omic network of insulin action in FAO hepatoma cells using transcriptom
Externí odkaz:
https://doaj.org/article/298b57f6bf194eb08a0765046fd90937