Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Katsuyuki Kunida"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Bioprocess optimization using mathematical models is prevalent, yet the discrepancy between model predictions and actual processes, known as process-model mismatch (PMM), remains a significant challenge. This study proposes a novel hybrid co
Externí odkaz:
https://doaj.org/article/0787c24fb20a452182be19fd641f61c8
Autor:
Yuichi SAKUMURA, Katsuyuki KUNIDA
Publikováno v:
Journal of Biomechanical Science and Engineering, Vol 18, Iss 4, Pp 23-00336-23-00336 (2023)
Despite considerable advancements in biological measurement technologies, capturing the simultaneous temporal changes in various biomolecular concentrations remains a challenge. Overcoming this technical difficulty via data preprocessing could not on
Externí odkaz:
https://doaj.org/article/8a6c6bf0a71c4dd69026ec5853ea10ee
Autor:
Daisuke Hoshino, Kentaro Kawata, Katsuyuki Kunida, Atsushi Hatano, Katsuyuki Yugi, Takumi Wada, Masashi Fujii, Takanori Sano, Yuki Ito, Yasuro Furuichi, Yasuko Manabe, Yutaka Suzuki, Nobuharu L. Fujii, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101558- (2020)
Summary: Skeletal muscle adaptation is mediated by cooperative regulation of metabolism, signal transduction, and gene expression. However, the global regulatory mechanism remains unclear. To address this issue, we performed electrical pulse stimulat
Externí odkaz:
https://doaj.org/article/9fb0ce1309754d78a3727d73981942e8
Autor:
Sarah Filippi, Chris P. Barnes, Paul D.W. Kirk, Takamasa Kudo, Katsuyuki Kunida, Siobhan S. McMahon, Takaho Tsuchiya, Takumi Wada, Shinya Kuroda, Michael P.H. Stumpf
Publikováno v:
Cell Reports, Vol 15, Iss 11, Pp 2524-2535 (2016)
Cellular signaling processes can exhibit pronounced cell-to-cell variability in genetically identical cells. This affects how individual cells respond differentially to the same environmental stimulus. However, the origins of cell-to-cell variability
Externí odkaz:
https://doaj.org/article/167f1e5d7573486fb67dbe22fa9a2acc
Autor:
Takaho Tsuchiya, Masashi Fujii, Naoki Matsuda, Katsuyuki Kunida, Shinsuke Uda, Hiroyuki Kubota, Katsumi Konishi, Shinya Kuroda
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 12, p e1005913 (2017)
Cells decode information of signaling activation at a scale of tens of minutes by downstream gene expression with a scale of hours to days, leading to cell fate decisions such as cell differentiation. However, no system identification method with suc
Externí odkaz:
https://doaj.org/article/6fd86c966a7a455a8babe7d749ee4249
Autor:
Katsuyuki Yugi, Hiroyuki Kubota, Yu Toyoshima, Rei Noguchi, Kentaro Kawata, Yasunori Komori, Shinsuke Uda, Katsuyuki Kunida, Yoko Tomizawa, Yosuke Funato, Hiroaki Miki, Masaki Matsumoto, Keiichi I. Nakayama, Kasumi Kashikura, Keiko Endo, Kazutaka Ikeda, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 1171-1183 (2014)
Cellular homeostasis is regulated by signals through multiple molecular networks that include protein phosphorylation and metabolites. However, where and when the signal flows through a network and regulates homeostasis has not been explored. We have
Externí odkaz:
https://doaj.org/article/5aeb92b1cd164234a5216b8ad109b25a
The optimization of bioprocess inputs using mathematical models is widely practiced. However, the mismatch between model prediction and the actual process [called process-model mismatch (PMM)] is problematic; when a large PMM exists, the process inpu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95e5ae337f51eb1e240dcc16b1cba31d
https://doi.org/10.1101/2023.04.10.536196
https://doi.org/10.1101/2023.04.10.536196
Fed-batch culture enables high productivity by maintaining low substrate concentrations in the early stage of the culture to suppress the accumulation of by-products that are harmful to cell growth. Therefore, they are widely used in the production o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc4130fb8bcc63ef048d7f19917c9756
https://doi.org/10.1101/2022.12.28.522066
https://doi.org/10.1101/2022.12.28.522066
Autor:
Naoki Matsuda, Yasuko Manabe, Haruki Inoue, Nobuharu L. Fujii, Takumi Wada, Hiroyuki Noji, Daisuke Hoshino, Shinya Kuroda, Hiromi Imamura, Yasuro Furuichi, Ken-ichi Hironaka, Miki Eto, Katsuyuki Kunida, Masashi Fujii
Publikováno v:
Quantitative Biology. 8:228-237
ATP is the major energy source for myotube contraction, and is quickly produced to compensate ATP consumption and to maintain sufficient ATP level. ATP is consumed mainly in cytoplasm and produced in mitochondria during myotube contraction. To unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea0b63478ecc73dd09ee5bd08c5837a8
https://doi.org/10.1007/s40484-020-0211-8
https://doi.org/10.1007/s40484-020-0211-8
Publikováno v:
Cell Reports. 42:112071
The inability to simultaneously observe all of the important Rho GTPases (Cdc42, Rac1, and RhoA) has prevented us from obtaining evidence of their coordinated regulation during cell deformation. Here, we propose Motion-Triggered Average (MTA), an alg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82452f8a70b6b8235789a287abec2488
https://doi.org/10.1016/j.celrep.2023.112071
https://doi.org/10.1016/j.celrep.2023.112071