Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Katsuyuki, Maki"'
Autor:
Shinobu Takeda, Takanobu Araki, Souichirou Akamatsu, Katsuyuki Maki, Satoko Uchida, David A. Barrett, Satoru Matsumoto, Kayakiri Natsuko, Toru Nakai, Masaki Tomishima, Hiroshi Morikawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1172-1175
The synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition and significantly improved MIC against Candida parapsilosis and echinocandin resistant-Candida is described.
Autor:
Katsuyuki Maki, Shuji Kaneko
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics
An assessment of the effective in vivo concentrations of antifungal drugs is important in determining their pharmacodynamics, and therefore, their optimal dosage regimen. Here we establish the effective in vivo concentration-based pharmacodynamics of
Autor:
Kazuaki Hatakenaka, Masakazu Niimi, Matthew A. Woods, Katsuyuki Maki, Kyoko Niimi, Fumiaki Ikeda, Hiroji Chibana, Hironobu Nakayama, Brian C. Monk, Keigo Ueno, Richard D. Cannon
Publikováno v:
Journal of Antimicrobial Chemotherapy. 67:1666-1676
OBJECTIVES A mechanism for the acquisition of high-level echinocandin resistance in Candida glabrata was investigated. FKS mutants were constructed to: determine whether clinically significant micafungin resistance requires a hot-spot mutation in FKS
Autor:
Takahiko Ishikawa, Tohru Takata, Souichirou Akamatsu, Kazuaki Hatakenaka, Satoru Matsumoto, Katsuyuki Maki, Fumiaki Ikeda, Rukako Tamai, Kazuo Tamura
Publikováno v:
Japanese Journal of Infectious Diseases. 63:332-337
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2886-2890
Further optimization of the potent antifungal activity of side chain analogs of the natural product FR901379 led to the discovery of compound 8 with an excellent, well-balanced profile. Potent compounds with reduced hemolytic potential were designed
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1474-1477
A series of novel acylated analogs of the novel water-soluble echinocandin FR901379 have been prepared and evaluated for antifungal and hemolytic activity. A relationship between antifungal activity and lipophilicity of the acyl side chain, expressed
Autor:
Shuichi Tawara, Seitaro Mutoh, Fumiaki Ikeda, Etsuko Watabe, Yumi Iguchi, Satoru Matsumoto, Katsuyuki Maki, Ann R. Holmes
Publikováno v:
Scopus-Elsevier
The aim of this study was to compare the pharmacodynamics of the azole antifungal drugs fluconazole, itraconazole and ketoconazole, and the polyene antifungal amphotericin B, in a mouse model of disseminated Candida albicans infection. In order to di
Publikováno v:
Folia Pharmacologica Japonica. 130:45-51
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1843-1849
A series of tyrosine-modified derivatives of the macrocyclic lipopeptidolactone FR901469 have been prepared and evaluated for in vitro and in vivo antifungal activity and for hemolytic activity towards red blood cells. Compound 14 displayed significa
Publikováno v:
The Journal of Antibiotics. 54:844-847