Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Katsuyoshi Mitsunaga"'
Autor:
Atsuko Miyajima, Yukie Kuroda, Kazue Sakemi-Hoshikawa, Makoto Usami, Katsuyoshi Mitsunaga, Tomohiko Irie, Yasuo Ohno, Momoko Sunouchi
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 979-985 (2020)
Effects of 4-methyl-2-mercaptobenzimidazole (4-MeMBI) and 5-methyl-2- mercaptobenzimidazole (5-MeMBI) on cytochrome P450 (CYP) activity were examined in primary cultured rat hepatocytes. Hepatocytes from male Wistar rats were cultured in the presence
Externí odkaz:
https://doaj.org/article/2baa9904a5d44238b2664d345c8d630b
Autor:
Yukie Kuroda, Tomohiko Irie, Momoko Sunouchi, Makoto Usami, Katsuyoshi Mitsunaga, Atsuko Miyajima, Yasuo Ohno, Kazue Sakemi-Hoshikawa
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 7, Iss, Pp 979-985 (2020)
Toxicology Reports, Vol 7, Iss, Pp 979-985 (2020)
Highlights • 4-MeMBI, 5-MeMBI and MBI inhibit CYP3A2 activity in cultured rat hepatocytes. • 4-MeMBI and 5-MeMBI, not MBI, induce CYP1A1/2 activity in cultured rat hepatocytes. • Effects of the chemicals on CYP3A2 suggest metabolic drug-drug in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f841b01fe0cb2c3d09b39c966554da63
http://europepmc.org/articles/PMC7451710
http://europepmc.org/articles/PMC7451710
Autor:
Atsuko Miyajima, Yasuo Ohno, Kazue Sakemi-Hoshikawa, Yukie Kuroda, Katsuyoshi Mitsunaga, Makoto Usami, Momoko Sunouchi
Publikováno v:
Fundamental Toxicological Sciences. 7:249-252
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5688d69970d0f9311610880cc8b2025a
https://doi.org/10.2131/fts.7.249
https://doi.org/10.2131/fts.7.249
Autor:
Makoto Usami, Yasuo Ohno, Kazue Sakemi-Hoshikawa, Momoko Sunouchi, Atsuko Miyajima, Yukie Kuroda, Tomohiko Irie, Katsuyoshi Mitsunaga
Publikováno v:
Fundamental Toxicological Sciences. 5:113-116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40c3327aef2072cdea95554ed8fb16b2
https://doi.org/10.2131/fts.5.113
https://doi.org/10.2131/fts.5.113
Autor:
Makoto Usami, Tomohiko Irie, Yasuo Ohno, Atsuko Miyajima, Katsuyoshi Mitsunaga, Kazue Sakemi-Hoshikawa, Momoko Sunouchi
Publikováno v:
Biochemical and Biophysical Research Communications. 492:116-120
We examined the effects of thyrotoxic rubber antioxidants, 2-mercaptobenzimidazole (MBI, 0.3 mmol/kg/day) and its methyl derivatives, methyl-MBIs [4-methyl-MBI (4-MeMBI, 0.6 mmol/kg/day), 5-methyl-MBI (5-MeMBI, 0.6 mmol/kg/day), and 4(or 5)-methyl-MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5c84ca78a9f463782cfba295e059f2
https://doi.org/10.1016/j.bbrc.2017.08.024
https://doi.org/10.1016/j.bbrc.2017.08.024
Autor:
Shugo Kazama, Tatsuya Takizawa, Tomohiko Irie, Mina Takamatu, Osamu Doi, Makoto Usami, Atsuko Miyajima, Katsuyoshi Mitsunaga
Publikováno v:
Congenital Anomalies. 56:52-59
The inhibition of neural crest cell (NCC) migration has been considered as a possible pathogenic mechanism underlying chemical developmental toxicity. In this study, we examined the effects of 13 developmentally toxic chemicals on the migration of ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c08968ec344118220ad021fc1ea4b6a0
https://doi.org/10.1111/cga.12121
https://doi.org/10.1111/cga.12121
Autor:
Makoto Usami1 usami@nihs.go.jp, Katsuyoshi Mitsunaga2, Tomohiko Irie1, Atsuko Miyajima3, Osamu Doi4
Publikováno v:
Journal of Toxicological Sciences. May2014, Vol. 39 Issue 2, p285-292. 8p.
Publikováno v:
Congenital Anomalies. 54:184-188
Here, we describe a simple in vitro neural crest cell (NCC) migration assay and the effects of all-trans-retinoic acid (RA) on NCCs. Neural tubes excised from the rhombencephalic or trunk region of day 10.5 rat embryos were cultured for 48 h to allow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53c4975d551c2ae1f3ca80227049d3b3
https://doi.org/10.1111/cga.12059
https://doi.org/10.1111/cga.12059
Publikováno v:
The International Journal of Developmental Biology. 54:1277-1285
A presumed embryotrophic factor for early postimplantation rat embryos, partially purified from rat serum, was identified as complement component C3 (C3), the central component of the complement system, by sequence analysis of its N-terminal. Purifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663a6d5b44e5c140e3dd65eb26c4fc10
https://doi.org/10.1387/ijdb.092993mu
https://doi.org/10.1387/ijdb.092993mu
Autor:
Momoko Sunouchi, Katsuyoshi Mitsunaga, Mikio Nakajima, Atsuko Miyajima, Osamu Doi, Makoto Usami
Publikováno v:
Reproductive Toxicology. 28:477-488
Indium embryotoxicity was investigated by proteomic analysis with two-dimensional electrophoresis of rat embryos cultured from day 10.5 of gestation for 24h in the presence of 50 microM indium trichloride. In the embryo proper, indium increased quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77623ccff40580e66ac7de3ab43324f2
https://doi.org/10.1016/j.reprotox.2009.06.008
https://doi.org/10.1016/j.reprotox.2009.06.008