Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Katsuyasu Saigo"'
Autor:
Mari Kono, Shiori Matsuhiroya, Ayako Obuchi, Takayuki Takahashi, Shion Imoto, Seiji Kawano, Katsuyasu Saigo
Publikováno v:
Journal of International Medical Research, Vol 48 (2020)
Objective Reactive oxygen species (ROS) production by neutrophils induces pulmonary endothelial cell damage and results in acute lung injury (ALI). We previously reported that deferasirox (DFS), an iron-chelating agent, inhibits the ROS production an
Externí odkaz:
https://doaj.org/article/798e927a1ab74d6cbb1beb77408d01f7
Publikováno v:
Biochemistry and Biophysics Reports, Vol 11, Iss C, Pp 147-153 (2017)
Formation of neutrophil extracellular traps (NETs) can perpetuate sterile inflammation; thus, it is important to clarify their pathophysiological characteristics. Free heme, derived via hemolysis, is a major contributor to organ damage, and reportedl
Externí odkaz:
https://doaj.org/article/d6e473ccced44291ab961b200df61169
Publikováno v:
Case Reports in Hematology, Vol 2015 (2015)
We report two cases of primary cold agglutinin disease (CAD) associated with megaloblastic anemia in Japanese elderly patients. Case 1 was a 67-year-old male and Case 2 was a 55-year-old male. Both patients were diagnosed with primary CAD, with conti
Externí odkaz:
https://doaj.org/article/a8b0eff2d8ce4e65b0244f35a50ab5d9
Publikováno v:
Case Reports in Hematology, Vol 2015 (2015)
In splenic marginal zone lymphoma (SMZL), there are cases that cannot accurately be classified as such because of overlapping morphologic and/or immunophenotypic features. We report here a 76-year-old Japanese female, who showed leukemic B-cell lymph
Externí odkaz:
https://doaj.org/article/c34158e8c9ce49de9c8b8d5250595c8a
Autor:
Setsuki Isono, Katsuyasu Saigo, Keiko Nagata, Keiko Numata, Toshiaki Kojitani, Akiharu Okamura, Akihiko Nishizawa, Masafumi Takata, Mariko Takenokuchi, Eiji Tatsumi
Publikováno v:
Hematology Reports, Vol 5, Iss 1, Pp e5-e5 (2013)
Although reports of typical acute promyelocytic leukemia (APL) cases rarely mention dysplastic changes, this report concerns a rare case of APL with tri-lineage dysplastic changes resembling the characteristic features of myelodysplastic syndrome (MD
Externí odkaz:
https://doaj.org/article/65187aa5c4d246999ebd4bf34b7677a2
Autor:
Mariko Takenokuchi, Seiji Kawano, Yuji Nakamachi, Yasuyuki Sakota, Meilani Syampurnawati, Katsuyasu Saigo, Eiji Tatsumi, Shunichi Kumagai
Publikováno v:
Hematology Reports, Vol 4, Iss 4, Pp e22-e22 (2012)
Acute promyelocytic leukemia (APL) is characterized by the specific PML-RARa fusion gene resulting from translocation t(15;17) (q22;q12). Internal tandem duplication (ITD) of the FLT3 gene has been observed in approximately 35% of APLs, and large-sca
Externí odkaz:
https://doaj.org/article/12a7c1c8dfb44b99a4d77d301a47cf27
Autor:
Naoki Yamamoto, Takuya Tokumon, Ayako Obuchi, Mari Kono, Katsuyasu Saigo, Mamoru Tanida, Yuri Ikeda‐Matsuo, Kazuya Sobue
Publikováno v:
Journal of Neurochemistry. 163:517-530
Inflammation associated with viral infection of the nervous system has been involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease (AD) and multiple sclerosis. Polyinosinic:polycytidylic acid (poly[I:C]) is a Toll-lik
Detection of activated neutrophils by reactive oxygen species production using a hematology analyzer
Autor:
Shion Imoto, Takashi Nishiyama, Katsuyasu Saigo, Seiji Kawano, Mari Kono, Makoto Hashimoto, Takayuki Takahashi, Shiori Matsuhiroya, Ayako Obuchi
Publikováno v:
Journal of Immunological Methods. 463:122-126
Neutrophils are recruited to infection sites and kill bacteria by phagocytosis and reactive oxygen species (ROS) production. It has been reported that vacuoles are present in neutrophils that produce ROS and are present in large numbers in blood smea
Autor:
Katsuyasu Saigo, Mari Kono, Shion Imoto, Yukiko Shibuya, Takashi Suzuki, Yuji Mizokoshi, Ayako Ohbuchi, Tohru Sawamura
Publikováno v:
Transfusion and Apheresis Science. 61:103319
Background In transfusion-related iron overload, haem-derived iron accumulation in monocytes/macrophages is the initial event. When iron loading exceeds the ferritin storage capacity, iron is released into the plasma. When iron loading exceeds transf
Autor:
Takashi Suzuki, Shion Imoto, Yukiko Shibuya, Yuji Mizokoshi, Katsuyasu Saigo, Ayako Ohbuchi, Mari Kono, Hirohide Sawada, Tohru Sawamura
Publikováno v:
Transfusion and Apheresis Science. 57:524-531
Background Iron overload is a major issue for transfusion-dependent patients. Repeated transfusions result in the loading of large amounts of haem-derived iron on macrophages, and the haemin in turn induces cell death and the generation of reactive o