Dynamics of directional motor tuning in the primate premotor and primary motor cortices during sensorimotor learning

Autor: Teppei Ebina, Akitaka Sasagawa, Dokyeong Hong, Rieko Setsuie, Keitaro Obara, Yoshito Masamizu, Masashi Kondo, Shin-Ichiro Terada, Katsuya Ozawa, Masato Uemura, Masafumi Takaji, Akiya Watakabe, Kenta Kobayashi, Kenichi Ohki, Tetsuo Yamamori, Masanori Murayama, Masanori Matsuzaki

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Abstract Sensorimotor learning requires reorganization of neuronal activity in the premotor cortex (PM) and primary motor cortex (M1). To reveal PM- and M1-specific reorganization in a primate, we conducted calcium imaging in common marmosets while t

Externí odkaz: https://doaj.org/article/7c710459480c402cbd4a10117bc17fa4

Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

Autor: Yuki Oe, Xiaowen Wang, Tommaso Patriarchi, Ayumu Konno, Katsuya Ozawa, Kazuko Yahagi, Hirokazu Hirai, Takashi Tsuboi, Tetsuya Kitaguchi, Lin Tian, Thomas J. McHugh, Hajime Hirase

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Astrocytic GPCRs activate Ca2+ and cAMP signaling pathways, however, the in vivo dynamics of the two second messengers have not been fully been characterized. The authors demonstrate distinct noradrenaline-induced astrocytic Ca2+ and cAMP dynamics du

Externí odkaz: https://doaj.org/article/de4152a6e93445c59df4faa68661c234

Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement

Autor: Youichi Iwai, Katsuya Ozawa, Kazuko Yahagi, Tsuneko Mishima, Sonam Akther, Camilla Trang Vo, Ashley Bomin Lee, Mika Tanaka, Shigeyoshi Itohara, Hajime Hirase

Publikováno v: Frontiers in Neural Circuits, Vol 15 (2021)

Astrocytes elicit transient Ca2+ elevations induced by G protein-coupled receptors (GPCRs), yet their role in vivo remains unknown. To address this, transgenic mice with astrocytic expression of the optogenetic Gq-type GPCR, Optoα1AR, were establish

Externí odkaz: https://doaj.org/article/bfd0b5691e9447258417c4abb53e514d

Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

Autor: Xiaowen Wang, Yuki Oe, Takashi Tsuboi, Tommaso Patriarchi, Hirokazu Hirai, Hajime Hirase, Ayumu Konno, Lin Tian, Tetsuya Kitaguchi, Katsuya Ozawa, Kazuko Yahagi, Thomas J. McHugh

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Oe, Y, Wang, X, Patriarchi, T, Konno, A, Ozawa, K, Yahagi, K, Hirai, H, Tian, L, McHugh, T J & Hirase, H 2020, ' Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance ', Nature Communications, vol. 11, no. 1, 471 . https://doi.org/10.1038/s41467-020-14378-x
Nature communications, vol 11, iss 1
Nature Communications

Astrocytes may function as mediators of the impact of noradrenaline on neuronal function. Activation of glial α1-adrenergic receptors triggers rapid astrocytic Ca2+ elevation and facilitates synaptic plasticity, while activation of β-adrenergic rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1994ebee58269946d7bda6bd6342b0a0
https://doaj.org/article/de4152a6e93445c59df4faa68661c234

Cerebral blood flow modulation by Basal forebrain or whisker stimulation can occur independently of large cytosolic Ca2+ signaling in astrocytes.

Autor: Norio Takata, Terumi Nagai, Katsuya Ozawa, Yuki Oe, Katsuhiko Mikoshiba, Hajime Hirase

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e66525 (2013)

We report that a brief electrical stimulation of the nucleus basalis of Meynert (NBM), the primary source of cholinergic projection to the cerebral cortex, induces a biphasic cerebral cortical blood flow (CBF) response in the somatosensory cortex of

Externí odkaz: https://doaj.org/article/bcd771687c1248f38b065359ce947099