Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Katsuya Egawa"'
Autor:
Osamu Sekine, Satoshi Ugi, Ryozo Torii, Yoshio Nagai, Shinya Shimizu, Kazuhiro Ikeda, Atsunori Kashiwagi, Tatsuyuki Takada, Yoshihiko Nishio, Hiroshi Kimura, Baoliang Guo, Kun Shi, Katsuya Egawa, Takeshi Yoshizaki, Daisuke Koya, Hiroshi Maegawa
Publikováno v:
Journal of Biochemistry. 146:541-547
Protein-tyrosine phosphatase 1B (PTP1B) is a major regulator of insulin sensitivity. We have described a novel action of PTP1B in the induction of sterol regulatory element-binding protein-1 (SREBP-1) gene expression through activation of protein pho
Autor:
Hiroshi Maegawa, Ryuzo Torii, Atsunori Kashiwagi, Takeshi Yoshizaki, Shinya Shimizu, Kun Shi, Satoshi Ugi, Yoshihiko Nishio, Yoshio Nagai, Katsuya Egawa, Kazuhiro Ikeda, Hiroshi Kimura, Osamu Sekine, Tatsuyuki Takada
Publikováno v:
Biochemical and Biophysical Research Communications. 363:626-632
Sterol regulatory element-binding protein-1 (SREBP-1) is a key transcription factor in stimulating lipogenesis in the liver. Protein-tyrosine phosphatase 1B (PTP1B) induces SREBP-1 gene expression via protein phosphatase 2A (PP2A) activation. PTP1B i
Autor:
Shuichi Tsukada, Shiro Maeda, Satoshi Ugi, Takaaki Nakamura, Atsunori Kashiwagi, Yukari Tao, Katsuya Egawa, Kazuhiro Ikeda, Hiroshi Maegawa, Yoshio Nagai, Yoshihiko Nishio
Publikováno v:
Endocrinology. 147:1685-1696
We have reported the association of variations in the activating protein-2beta (AP-2beta) transcription factor gene with type 2 diabetes. This gene was preferentially expressed in 3T3-L1 adipocytes in a differentiation stage-dependent manner, and pre
Autor:
Atsunori Kashiwagi, Takaaki Nakamura, Yoshihiko Nishio, Katsuya Egawa, Tetsuya Hashimoto, Hiroshi Maegawa
Publikováno v:
Journal of Biological Chemistry. 280:1893-1900
We have reported that the combined expression of Pdx-1 (pancreatic duodenal homeobox 1) and Isl-1 (islet 1) enables immature rat enterocytes (IEC-6) to produce and release insulin. A key component regulating the release of insulin is the ATP-sensitiv
Publikováno v:
An Official Journal of the Japan Primary Care Association. 36:315-317
Autor:
Atsunori Kashiwagi, Kenichi Mitsunami, Eiji Suzuki, Yoshihiko Nishio, Shinji Inoue, Katsuya Egawa, Hiroshi Maegawa, Toshiro Inubushi, Shigehiro Morikawa, Masanobu Tsuchiya
Publikováno v:
Diabetes Care. 27:2409-2415
OBJECTIVE—To clarify whether stiffness and impaired blood flow in lower-leg arteries are associated with severity of coronary artery calcification among asymptomatic diabetic patients. RESEARCH DESIGN AND METHODS—We enrolled 102 asymptomatic type
Autor:
Yousuke Ebina, Toshiyuki Obata, Jerrold M. Olefsky, Kun Shi, Takeshi Yoshizaki, Takeshi Imamura, Satoshi Ugi, Katsuya Egawa, Atsunori Kashiwagi, Hiroshi Maegawa
Publikováno v:
Molecular and Cellular Biology. 24:8778-8789
Protein phosphatase 2A (PP2A) is a multimeric serine/threonine phosphatase which has multiple functions, including inhibition of the mitogen-activated protein (MAP) kinase pathway. Simian virus 40 small t antigen specifically inhibits PP2A function b
Autor:
Yoshihiko Nishio, Katsuya Egawa, Daniel Edmundowicz, Shinji Tamaki, Hirotsugu Ueshima, Wahid R. Zaky, Hiroshi Maegawa, Kiyoshi Murata, Kenichi Mitsunami, Y. Kita, Kim Sutton-Tyrrell, Atsunori Kashiwagi, Takashi Kadowaki, Lewis H. Kuller, Yasuyuki Nakamura, Akira Sekikawa, Hideyuki Kanda, Tomonori Okamura, Yoshiki Ueno
Publikováno v:
International Journal of Epidemiology. 34:173-179
Since World War II (WWII), exposures to westernized lifestyle have occurred in many non-Western countries, including Japan. The man born after WWII in Japan have had major changes in diet and other lifestyle factors, including heavy cigarette smoking
Autor:
Shinri Tamura, Hiroshi Maegawa, Jerrold M. Olefsky, Takeshi Imamura, Takeshi Yoshizaki, Katsuya Egawa, Yoshihiko Nishio, Satoshi Ugi, Atsunori Kashiwagi, Takayasu Kobayashi
Publikováno v:
Journal of Biological Chemistry. 279:22715-22726
During differentiation, expression of protein phosphatase-2Calpha (PP2Calpha) is increased in 3T3-L1 adipocytes. To elucidate the role of PP2Calpha in insulin signaling, we overexpressed wild-type (WT) PP2Calpha by adenovirus-mediated gene transfer i
Autor:
Katsuya Egawa, Michael Bryer-Ash, Atsunori Kashiwagi, Kun Shi, Shinya Shimizu, Hiroshi Maegawa
Publikováno v:
Endocrinology. 143:4563-4569
We investigated the effect of overexpression of protein-tyrosine phosphatase 1B (PTP1B) on insulin signaling in 3T3-L1 adipocytes. Overexpression of a wild-type PTP1B in L1 adipocytes as well as in L6 myocytes, led to a profound decrease in insulin-s