Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Katsuya, Awano"'
Autor:
Ronald B. Franklin, Masakatsu Komuro, Katsuya Awano, Zhongzhou Shen, Adria Colletti, William P. Feeney, Stella H. Vincent, Susan A. Iliff, Don Hora, Ray Bakhtiar, Fukutaro Taga
Publikováno v:
Rapid Communications in Mass Spectrometry. 19:1125-1129
MK-0767, (+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)phenyl]methyl]benzamide, is a thiazolidinedione-containing dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that has been studied as a pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::858117fdb7f804d25a82c4ef8f98a2cb
https://doi.org/10.1002/rcm.1897
https://doi.org/10.1002/rcm.1897
Publikováno v:
Tetrahedron: Asymmetry. 14:529-535
The lipase-catalyzed resolution of 2-(acyloxymethyl)-4,5-dihydro-5-methylpyridazin-3(2H)-one derivatives in organic solvents containing water was demonstrated to be a practical method for the synthesis of a chiral pyridazinone bearing a pyrazolopyrid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375be15f1bbd490571c4479dcfb59b39
https://doi.org/10.1016/s0957-4166(03)00030-2
https://doi.org/10.1016/s0957-4166(03)00030-2
Autor:
Shinji Kudoh, Yasushi Kohno, Saito Koji, Sakoe Yasuhiko, Mitsutomo Miyashita, Eisuke Kojima, Kazuhiko Kuriyama, Katsuya Awano, Shizuyoshi Fujimori
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1515-1518
A study of the modification of N -alkylanthranilic acids to develop novel DMARDs is detailed. 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid derivatives were found to exhibit a therapeutic effect on adjuvant arthritis and a suppressive effect on bone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a3950f437152c571c77baff207a93e1
https://doi.org/10.1016/s0960-894x(97)00261-8
https://doi.org/10.1016/s0960-894x(97)00261-8
Autor:
Mitsutomo Miyashita, Shinji Kudoh, Eisuke Kojima, Yasushi Kohno, Saito Koji, Takayoshi Ishizaki, Katsuya Awano, Kazuhiko Kuriyama, Sakoe Yasuhiko
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1519-1524
A study of the structural optimization of tetrahydroquinoline-6-acetic acid and the development of a novel DMARD with prompt action are detailed. ( S )-(+)-8-Chloro-1,2,3,4-tetrahydro-2-trifluoromethyl-6-quinolineacetic acid (IRA-378) exhibits the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d3273762000c60484a0da1431222990
https://doi.org/10.1016/s0960-894x(97)00262-x
https://doi.org/10.1016/s0960-894x(97)00262-x
Publikováno v:
Synthesis. 2004:1554-1556
The asymmetric synthesis of a (R)-4,5-dihydro-5-methylpyridazin-3(2H)-one derivative bearing a pyrazolopyridine ring, which is a potent inhibitor of phosphodiesterase, was achieved with a high optical yield in four steps starting from (R)-2-chloropro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06838bbae4a9867d496a6224411b6da5
https://doi.org/10.1055/s-2004-829107
https://doi.org/10.1055/s-2004-829107
Autor:
Shinji Kudoh, Yasushi Kohno, Sakoe Yasuhiko, Mitsutomo Miyashita, Katsuya Awano, Eisuke Kojima, Shizuyoshi Fujimori, Saito Koji, Kazuhiko Kuriyama
Publikováno v:
ChemInform. 28
A study of the modification of N -alkylanthranilic acids to develop novel DMARDs is detailed. 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid derivatives were found to exhibit a therapeutic effect on adjuvant arthritis and a suppressive effect on bone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f0c5ebcf71d7066868da7edd929fa7d
https://doi.org/10.1002/chin.199742181
https://doi.org/10.1002/chin.199742181
Autor:
Katsuya Awano, Eisuke Kojima, Mitsutomo Miyashita, Shinji Kudoh, Yasushi Kohno, Sakoe Yasuhiko, Takayoshi Ishizaki, Kazuhiko Kuriyama, Saito Koji
Publikováno v:
ChemInform. 28
A study of the structural optimization of tetrahydroquinoline-6-acetic acid and the development of a novel DMARD with prompt action are detailed. ( S )-(+)-8-Chloro-1,2,3,4-tetrahydro-2-trifluoromethyl-6-quinolineacetic acid (IRA-378) exhibits the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ce1e7ca6ee1c4965990989d7eb9888b
https://doi.org/10.1002/chin.199742182
https://doi.org/10.1002/chin.199742182
Autor:
Toshio Maeda, Koji Murakami, Katsuya Awano, Hiroyuki Miyachi, Susumu Kinoshita, Masaki Tsunoda, Masahiro Nomura, Hiroya Satoh
Publikováno v:
ChemInform. 30
A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure-activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a6d07cfe7ae8090611d64e8617f2ae3
https://doi.org/10.1002/chin.199926128
https://doi.org/10.1002/chin.199926128
Autor:
Hiroyuki Miyachi, Tomohiro Ide, Koji Murakami, Masaki Tsunoda, Katsuya Awano, Masahiro Nomura, Takahiro Tanase, Takahashi Yukie
Publikováno v:
ChemInform. 33
A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure–activity relationship studies indicated that the substitue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::043f5a3cd83c1b9ad9d58d701785a2c4
https://doi.org/10.1002/chin.200212121
https://doi.org/10.1002/chin.200212121
Autor:
Katsuya Awano, Masahiro Nomura, Hiroyuki Miyachi, Koji Murakami, Takahiro Tanase, Masahiro Suzuki
Publikováno v:
ChemInform. 33
Optically active phenylpropanoic acid derivatives [( S )- 5 , and ( R )- 5 ] were prepared, and their affinities for peroxisome proliferator-activated receptor (PPAR)α and PPARγ were evaluated. Binding assay and cell-based reporter assay indicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed965bc185d97a6a765e7b9148f1133b
https://doi.org/10.1002/chin.200224098
https://doi.org/10.1002/chin.200224098