Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export.

Autor: Daneshmandi S; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Yan Q; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Choi JE; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Katsuta E; Department of Oncology, Yokohama City University, Graduate School of Medicine, Yokohama, Japan., MacDonald CR; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Goruganthu M; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Roberts N; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Repasky EA; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Singh PK; Department of Cancer Genetics & Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Attwood K; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Wang J; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Landesman Y; Karyopharm Therapeutics, Newton, MA, USA., McCarthy PL; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Mohammadpour H; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. hemn.mohammadpour@roswellpark.org.

Publikováno v: Cellular & molecular immunology [Cell Mol Immunol] 2024 Aug; Vol. 21 (8), pp. 873-891. Date of Electronic Publication: 2024 Jun 20.

Dysregulation of sphingolipid metabolic enzymes leads to high levels of sphingosine-1-phosphate and ceramide in human hepatocellular carcinoma.

Autor: Miura K; Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan., Nagahashi M; Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan., Prasoon P; Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan., Hirose Y; Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan., Kobayashi T; Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan., Sakata J; Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan., Abe M; Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, Niigata, Japan., Sakimura K; Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, Niigata, Japan., Matsuda Y; Department of Medical Technology, Niigata University Graduate School of Health Sciences, Niigata, Niigata, Japan., Butash AL; Breast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA., Katsuta E; Breast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA., Takabe K; Breast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.; Department of Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.; Department of Breast Surgery and Oncology, Tokyo Medical University, Shinjuku, Tokyo, Japan.; Department of Surgery, Yokohama City University, Yokohama, Kanagawa, Japan., Wakai T; Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan.

Publikováno v: Hepatology research : the official journal of the Japan Society of Hepatology [Hepatol Res] 2021 May; Vol. 51 (5), pp. 614-626. Date of Electronic Publication: 2021 Mar 09.

Clinical relevance of tumor microenvironment: immune cells, vessels, and mouse models.

Autor: Katsuta E; Breast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Elm & Carlton Streets, Buffalo, NY, 14263, USA., Rashid OM; Holy Cross Hospital Michael and Dianne Bienes Comprehensive Cancer Center, Fort Lauderdale, FL, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.; Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Surgery, Nova Southeastern University School of Medicine, Fort Lauderdale, FL, USA., Takabe K; Breast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Elm & Carlton Streets, Buffalo, NY, 14263, USA. kazuaki.takabe@roswellpark.org.; Department of Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, NY, USA. kazuaki.takabe@roswellpark.org.; Department of Breast Surgery and Oncology, Tokyo Medical University, Tokyo, Japan. kazuaki.takabe@roswellpark.org.; Department of Surgery, Yokohama City University, Yokohama, Japan. kazuaki.takabe@roswellpark.org.; Department of Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. kazuaki.takabe@roswellpark.org.; Department of Breast Surgery, Fukushima Medical University, Fukushima, Japan. kazuaki.takabe@roswellpark.org.

Publikováno v: Human cell [Hum Cell] 2020 Oct; Vol. 33 (4), pp. 930-937. Date of Electronic Publication: 2020 Jun 07.

Loss-of-function of the hippo transducer TAZ reduces mammary tumor growth through a myeloid-derived suppressor cell-dependent mechanism.

Autor: Shen H; Department of Cancer Genetics & Genomics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Zhang Y; Department of Translational Immuno-Oncology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Kramer ED; Department of Immunology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Katsuta E; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Wan Y; Department of Molecular & Cellular Biology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Chen Y; Department of Cancer Genetics & Genomics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Wang J; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Zhang Y; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Matsuzaki J; Department of Translational Immuno-Oncology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Frangou C; Department of Molecular & Cellular Biology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Abrams SI; Department of Immunology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA. scott.abrams@roswellpark.org., Zhang J; Department of Cancer Genetics & Genomics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA. jianmin.zhang@roswellpark.org.

Publikováno v: Cancer gene therapy [Cancer Gene Ther] 2022 Nov; Vol. 29 (11), pp. 1791-1800. Date of Electronic Publication: 2022 Jul 15.

Mechano-Sensing Channel PIEZO2 Enhances Invasive Phenotype in Triple-Negative Breast Cancer.

Autor: Katsuta E; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Takabe K; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Department of Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, NY 14203, USA.; Department of Breast Surgery and Oncology, Tokyo Medical University, Tokyo 160-8402, Japan.; Department of Surgery, Yokohama City University, Yokohama 236-0004, Japan.; Department of Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.; Department of Breast Surgery, Fukushima Medical University, Fukushima 960-1295, Japan., Vujcic M; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Gottlieb PA; Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, USA., Dai T; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Mercado-Perez A; Enteric Neuroscience Program, Division of Gastroenterology & Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA., Beyder A; Enteric Neuroscience Program, Division of Gastroenterology & Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA., Wang Q; Department of Medicine, Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Opyrchal M; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Department of Medicine, Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Aug 31; Vol. 23 (17). Date of Electronic Publication: 2022 Aug 31.