Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Katsuo Unno"'
Autor:
Toshikiro Kimura, Yuji Kurosaki, Yasuyuki Matsuda, Toshio Suzuki, Takehiro Yamaguchi, Yukiko Fujiwara, Taiji Nakayama, Katsuo Unno, Kumi Usuki
Publikováno v:
Journal of Controlled Release. 30:125-135
Hydrophilic steriod derivatives, methyl 20-β-glucopyranosyloxyprednisolonates (15 and 16), were synthesizd from prenisolone via methyl 20( R/S )-dihydroprednisolonates (2 and 1) based on a novel colonic mucosa-specific drug delivery system. Optimal
Publikováno v:
Chemical and Pharmaceutical Bulletin. 41:244-247
Enantioselective syntheses of both (20R)- and (20S)-de-AB-cholesta-8(14), 22-dien-9-one (22 and 23), which are potential intermediates leading to vitamin D3, steroids and their analogues, have been developed. The (3R)-methyl-cyclopentanone 12 was obt
Publikováno v:
ChemInform. 23
Stereoselective introduction of a methyl group into the (3S)-2-methylcyclopentanone 3, followed by Claisen rearrangement of the vinyl ether 10 derived from the allyl alcohol 7 provided separable methyl esters 6a and 6b. Reduction of 6a and subsequent
Publikováno v:
ChemInform. 25
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :2017-2021
Stereoselective introduction of a methyl group into the (3S)-2-methylcyclopentanone 3, followed by Claisen rearrangement of the vinyl ether 10 derived from the allyl alcohol 7 provided separable methyl esters 6a and 6b. Reduction of 6a and subsequent
Publikováno v:
Drug Delivery System. 6:191-194
Autor:
Katsuo Unno, Toshikiro Kimura, Yuji Kurosaki, Yukiko Fujiwara, Takehiro Yamaguchi, Kumi Usuki, Toshio Suzuki, Taiji Nakayama
Publikováno v:
Drug Delivery System. 6:375-379
The fate of 20 (R/S)-glucopyranosyloxy methyl-prednisolonates after the oral administration was examined in rats and guinea-pigs. The glycosides were stable in the small-intestinal contents, but the glycoside bonds were cleaved by the action of bacte
Autor:
Akio Goto, Katsuo Unno
Publikováno v:
Journal of the Society of Powder Technology, Japan. 28:92-98
Autor:
Kazunobu Sugawara, Yoshito Nakagawa, Sumi Takahashi, Mitinao Mizugaki, Keiki Tanno, Makoto Ikeda, Katsuo Unno
Publikováno v:
Japanese Journal of Hospital Pharmacy. 17:38-45
The usability and functionality of a new infusion kit, which is contrived to include cephalosporin antibiotics and their dissolving solutions in a single container, was surveyed by questionare to hospital nurses engaging daily in preparation of injec
Autor:
Shinitsu Sato, Mamoru Miura, Ken Kadowaki, Hitoshi Tada, Katsuo Unno, Toshio Suzuki, Masato Hayashi, Tomohiro Kanazawa, Wataru Sasaki, Toshihide Shu, Makiko Homma
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 21:713-723
In order to determine the relationship between efficacy and plasma level of flecainide in ventricular premature contractions (VPC), a study was carried out through multipleadministration method in 15 patients with VPC at dose level of 50mg b.i.d., 10