Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Katsunori Tsuboi"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 44:128115
Kynurenine monooxygenase (KMO) is expected to be a good drug target to treat Huntington's disease (HD). This study presents the structure-activity relationship of pyridazine derivatives to find novel KMO inhibitors. The most promising compound 14 res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375ddeb5768db8eed4d7c0bd60b226ef
https://doi.org/10.1016/j.bmcl.2021.128115
https://doi.org/10.1016/j.bmcl.2021.128115
Autor:
Masanori Tobe, Norio Fujiwara, Masakazu Isobe, Katsunori Tsuboi, Futoshi Hasegawa, Yoshiaki Isobe, Yoshifumi Inoue
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1292-1295
We have designed and efficiently synthesized novel 1-phenyl-6-aminouracils by replacing the chroman moiety in CX-659S, a nonsteroidal dermatologic candidate, with dimethyldihydrobenzofuranol to cancel CX-659S asymmetric center. Medicinal chemistry ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c9fad4d05a6ede972b654a37a6f226
https://doi.org/10.1016/j.bmcl.2016.01.019
https://doi.org/10.1016/j.bmcl.2016.01.019
Autor:
Katsunori Tsuboi, Daniel A. Bachovchin, Benjamin F. Cravatt, Hugh Rosen, Anna E Speers, Virneliz Fernandez-Vega, Timothy P. Spicer, Peter Hodder
Publikováno v:
Journal of the American Chemical Society. 133:16605-16616
Glutathione S-transferases (GSTs) are a superfamily of enzymes that conjugate glutathione to a wide variety of both exogenous and endogenous compounds for biotransformation and/or removal. Glutathione S-tranferase omega 1 (GSTO1) is highly expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ed7481b46a25ee6e58ff3af4ea0cda
https://doi.org/10.1021/ja2066972
https://doi.org/10.1021/ja2066972
Autor:
Minoru Isobe, Sathorn Suwan, Jian-Min Li, Katsunori Tsuboi, Tatsuya Fujii, Masaki Kuse, Meow Chan Feng, Asaka Miyazaki
Publikováno v:
Pure and Applied Chemistry. 70:2085-2092
Bioluminescence of Okinawan squid includes a photoprotein named "Symplectin" which gives light by addition of Na+ (or K+). The chromophore is covalently bound-imidazopyrazinone analog to protein. Symplectin was extracted with 0.6M KC1 and was analyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::656d795c69917c7a10be2146dd7319a9
https://doi.org/10.1351/pac199870112085
https://doi.org/10.1351/pac199870112085
Autor:
Katsunori Tsuboi, Makoto Ubukata, Yoshiyasu Ichikawa, Minoru Isobe, Atsushi Naganawa, Kiyoshi Isono
Publikováno v:
Tetrahedron. 53:5083-5102
The synthesis of Segment B corresponding to the C26–C17 portion of tautomycin was accomplished by coupling reaction between the epoxide (Sub-segment B-1) and the dithiane (Sub-segment B-2). The degradation product of tautomycin corresponding to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79c349a0361656774d56cff37b67a2df
https://doi.org/10.1016/s0040-4020(97)00228-7
https://doi.org/10.1016/s0040-4020(97)00228-7
Autor:
S. Shibuya, Yoshiyasu Ichikawa, Seijiro Hosokawa, I. I. Ohtani, Kazunobu Kira, Minoru Isobe, M. Bamba, Katsunori Tsuboi, Toshio Nishikawa
Publikováno v:
Pure and Applied Chemistry. 69:401-406
Synthetic approach toward channel protein inhibitors (tetrodotoxin, ciguatoxin) and protein phosphatase inhibitors (tautomycin) is discussed with special reference to the stereochemical control. Stereochemical control in organic synthesis is the majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2362fd80239f28f2b4ac94f49d5d506a
https://doi.org/10.1351/pac199769030401
https://doi.org/10.1351/pac199769030401
Autor:
Landon R. Whitby, Katsunori Tsuboi, Holly Pugh, Anna E Speers, Jae Won Chang, Ku-Lung Hsu, Benjamin F. Cravatt
Publikováno v:
Journal of medicinal chemistry. 56(21)
Alpha/beta-hydrolase domain containing 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes the endogenous cannabinoid 2-arachidonoylglycerol (2-AG) to regulate certain forms of cannabinoid receptor-dependent signaling in the nervous system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00159d9528b985fccf4caadc7e31e68d
https://pubmed.ncbi.nlm.nih.gov/24152295
https://pubmed.ncbi.nlm.nih.gov/24152295
Autor:
Landon R. Whitby, Katsunori Tsuboi, Ku-Lung Hsu, Jordon M. Inloes, Benjamin F. Cravatt, Holly Pugh, Anna E Speers
We have previously shown that 1,2,3-triazole ureas (1,2,3-TUs) act as versatile class of irreversible serine hydrolase inhibitors that can be tuned to create selective probes for diverse members of this large enzyme class, including diacylglycerol li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2337c61bfc71e57c7d5c2c68b8ed890f
https://europepmc.org/articles/PMC3984011/
https://europepmc.org/articles/PMC3984011/
Autor:
Jill Ferguson, Timothy P. Spicer, Peter Hodder, Jae Won Chang, Daniel A. Bachovchin, Alexander Adibekian, Hugh Rosen, Steven J. Brown, Virneliz Fernandez-Vega, Ku-Lung Hsu, Katsunori Tsuboi, Benjamin F. Cravatt, Brent R. Martin, Anna E Speers
Publikováno v:
Journal of the American Chemical Society. 134(25)
The development of small-molecule inhibitors for perturbing enzyme function requires assays to confirm that the inhibitors interact with their enzymatic targets in vivo. Determining target engagement in vivo can be particularly challenging for poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edeeaa597c3f1d50e0a6eec3b7ffa537
https://pubmed.ncbi.nlm.nih.gov/22690931
https://pubmed.ncbi.nlm.nih.gov/22690931
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::671dd6a28a14037492f95f440a3bdc00
https://doi.org/10.1002/chin.199434269
https://doi.org/10.1002/chin.199434269