Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Katsunori Takashima"'
Autor:
Hitoshi Ikeda, Takuzo Ishidate, Yoshikazu Araya, Kazuhiro Kudo, Kimiko Dota, Norihiko Shimoyama, Katsunori Takashima, Noriko Kimura, Kazuko Abe, Tsuguru Ikeda
Publikováno v:
The Journal of the Japanese Society of Clinical Cytology. 48:336-341
目的 : 私達は中皮腫の細胞診に特徴的な所見をスコア化し, 中皮腫診断におけるその有用性を検討した.方法 : 病理組織診断により中皮腫であることが確認された 19 例の体腔液を検討した
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d132e5370e5e6094449ea7101e83f934
https://doi.org/10.5795/jjscc.48.336
https://doi.org/10.5795/jjscc.48.336
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:707-715
TAK-652, a novel small-molecule chemokine receptor antagonist, is a highly potent and selective inhibitor of CCR5-using (R5) human immunodeficiency virus type 1 (HIV-1) replication in vitro. Since TAK-652 is orally bioavailable and has favorable phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa700ff26bf2080126b286b446b71c49
https://doi.org/10.1128/aac.01079-06
https://doi.org/10.1128/aac.01079-06
Autor:
Katsunori Takashima, Yuji Iizawa, Naoyuki Kanzaki, Youichi Nishikawa, Masanori Baba, Shin-Ichi Niwa, Shinichi Imamura, Yoshihiro Sugihara, Takashi Ichikawa
Publikováno v:
Journal of Medicinal Chemistry. 49:2784-2793
We incorporated various polar groups into previously described piperidine-4-carboxamide CCR5 antagonists to improve their metabolic stability in human hepatic microsomes. Introducing a carbamoyl group into the phenyl ring of the 4-benzylpiperidine mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8316fb31b25d5d6ef25cf70fad177ac5
https://doi.org/10.1021/jm051034q
https://doi.org/10.1021/jm051034q
Autor:
Mitsuru Shiraishi, Katsuji Aikawa, Yuji Iizawa, Masanori Baba, Katsunori Takashima, Yoji Kuze, Naoki Miyamoto, Naoyuki Kanzaki, Masaki Seto, Yoshio Aramaki
Publikováno v:
Journal of Medicinal Chemistry. 49:2037-2048
Chemical modification has been performed on an orally bioavailable and potent CCR5 antagonist, sulfoxide compound 4, mainly focusing on replacement of the [6,7]-fused 1-benzazepine nucleus. We designed, synthesized, and evaluated the biological activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d22a8c010c13bcf7fcf740e76eca238
https://doi.org/10.1021/jm0509703
https://doi.org/10.1021/jm0509703
Publikováno v:
The Journal of the Japanese Society of Clinical Cytology. 45:1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15d3e96d34de7e761507bae39d532e63
https://doi.org/10.5795/jjscc.45.1
https://doi.org/10.5795/jjscc.45.1
Autor:
Mitsuru Shiraishi, Masanori Baba, Hiroshi Miyake, Jun-ichi Fujisawa, Katsunori Takashima, Naoyuki Kanzaki, Rika A. Furuta, Yuji Iizawa, Kenji Okonogi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 45:3538-3543
We established a human immunodeficiency virus type 1 (HIV-1) envelope (Env)-mediated membrane fusion assay and examined the small-molecule CCR5 antagonist TAK-779 and its derivatives for their inhibitory effects on HIV-1 Env-mediated membrane fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096d7edf2e70a7f0124a227d7dc7282f
https://doi.org/10.1128/aac.45.12.3538-3543.2001
https://doi.org/10.1128/aac.45.12.3538-3543.2001
Autor:
Masayuki, Keisuke Miyamoto, Koichi Fukunaga, Yasushi Nakano, Yoshiki Shiraishi, Kiyoshi Moriyama, Naoko Matsunaga, T Matsumoto, Sadatomo Tasaka, Junzo Takeda, Katsunori Takashima, Akitoshi Ishizaka, Hiroyuki Seki
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 59(10)
Toll-like receptor 4 (TLR4) plays important roles in the recognition of lipopolysaccharide (LPS) and the activation of inflammatory cascade. In this study, we evaluated the effect of TAK-242, a selective TLR4 signal transduction inhibitor, on acute l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92478ecca5ea418f1049d91fec2ad1ed
https://pubmed.ncbi.nlm.nih.gov/20387088
https://pubmed.ncbi.nlm.nih.gov/20387088
Autor:
Kaoru Hazeki, Masayuki, Tsukasa Seya, Katsunori Takashima, Naoko Matsunaga, Yuji Iizawa, Tomoyuki Kitazaki, Kazuyo Nakamura, Osamu Hazeki
Publikováno v:
Molecular pharmacology. 69(4)
Proinflammatory mediators such as cytokines and NO play pivotal roles in various inflammatory diseases. To combat inflammatory diseases successfully, regulation of proinflammatory mediator production would be a critical process. In the present study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbab6bf6cf32fd4653a3cd5f6310ddd
https://pubmed.ncbi.nlm.nih.gov/16373689
https://pubmed.ncbi.nlm.nih.gov/16373689
Autor:
Mitsuru Shiraishi, Yuji Iizawa, Xin Wang, Hiroshi Miyake, Naoyuki Kanzaki, Koichiro Teshima, Masanori Baba, Katsunori Takashima
The first small-molecule CCR5 antagonist, TAK-779, could not be developed as an anti-human immunodeficiency virus type (anti-HIV-1) agent because of its poor oral bioavailability. TAK-652 is an orally bioavailable TAK-779 derivative with potent anti-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8167605c48d97a10b8d0a4550e8e6f77
https://europepmc.org/articles/PMC1280155/
https://europepmc.org/articles/PMC1280155/
Autor:
Rika A. Furuta, Naoyuki Kanzaki, Yoshio Yamamoto, Katsunori Takashima, Toshiya Nishi, Masao Nishikawa, Jun-ichi Fujisawa
G protein-coupled receptor CCR5 is the main coreceptor for macrophage-tropic human immunodeficiency virus type 1 (HIV-1), and various small-molecule CCR5 antagonists are being developed to treat HIV-1 infection. It has been reported that such CCR5 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f53b641b223aaff9f3ac8b8afd37cfc
https://europepmc.org/articles/PMC1280122/
https://europepmc.org/articles/PMC1280122/