Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Katsunori Nagai"'
Autor:
Osamu Ujikawa, Takayuki Hattori, Nobumichi Ohoka, Nobuo Cho, Naoki Miyamoto, Norihito Shibata, Hiroshi Nara, Kenichiro Shimokawa, Katsunori Nagai, Tomoya Sameshima, Mikihiko Naito
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
Chronic myelogenous leukemia (CML) is characterized by the oncogenic fusion protein, BCR-ABL protein kinase, against which clinically useful inhibitors have been developed. An alternative approach to treat CML is to degrade the BCR-ABL protein. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c787a44650f5c51a7421cbedbfa1c48
http://link.springer.com/article/10.1038/s41598-018-31913-5
http://link.springer.com/article/10.1038/s41598-018-31913-5
Autor:
Osamu Ujikawa, Yoko Morita, Kenichiro Shimokawa, Takayuki Hattori, Masahiro Ito, Tomoya Sameshima, Keiichiro Okuhira, Katsunori Nagai, Ikuo Fujimori, Yasuhiro Imaeda, Hiroshi Nara, Ryokichi Koyama, Mikihiko Naito, Youji Hayase, Nobuo Cho, Nobumichi Ohoka, Norihito Shibata, Osamu Sano
Publikováno v:
Journal of Biological Chemistry. 293:6776-6790
Aberrant expression of proteins often underlies many diseases, including cancer. A recently developed approach in drug development is small molecule-mediated, selective degradation of dysregulated proteins. We have devised a protein-knockdown system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71858240322a34c0d71fbf5734e371d
https://doi.org/10.1074/jbc.ra117.001091
https://doi.org/10.1074/jbc.ra117.001091
Autor:
Nobumichi Ohoka, Mikihiko Naito, Nobuo Cho, Takayuki Hattori, Hiroshi Nara, Norihito Shibata, Katsunori Nagai
Publikováno v:
Cancer Science
We previously developed a hybrid small molecule SNIPER (Specific and Nongenetic IAP-dependent Protein ERaser) against transforming acidic coiled-coil-3 (TACC3), SNIPER(TACC3), that induces proteasomal degradation of TACC3 protein. In this study, we f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4202d1c0137e67eabed705990a147261
https://doi.org/10.1111/cas.13198
https://doi.org/10.1111/cas.13198
Autor:
Nobumichi Ohoka, Norihito Shibata, Mikihiko Naito, Kenichiro Shimokawa, Nobuo Cho, Hiroshi Nara, Hirokazu Matsumoto, Osamu Sano, Ryokichi Koyama, Hisashi Fujita, Masahiro Ito, Katsunori Nagai, Yasuhiro Imaeda, Takayuki Hattori, Keiichiro Okuhira, Osamu Ujikawa, Mika Teratani
Publikováno v:
Journal of Biological Chemistry. 292:4556-4570
Many diseases, especially cancers, result from aberrant or overexpression of pathogenic proteins. Specific inhibitors against these proteins have shown remarkable therapeutic effects, but these are limited mainly to enzymes. An alternative approach t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81db1525450bb91feeaa74e7def011c
https://doi.org/10.1074/jbc.m116.768853
https://doi.org/10.1074/jbc.m116.768853
Autor:
Osamu Sano, Ryokichi Koyama, Osamu Ujikawa, Yoko Morita, Hiroshi Nara, Nobumichi Ohoka, Norihito Shibata, Mikihiko Naito, Takayuki Hattori, Nobuo Cho, Katsunori Nagai, Yasuhiro Imaeda
Publikováno v:
Journal of medicinal chemistry. 61(2)
Targeted protein degradation using small molecules is a novel strategy for drug development. We have developed hybrid molecules named specific and nongenetic inhibitor of apoptosis protein [IAP]-dependent protein erasers (SNIPERs) that recruit IAP ub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d823461c97af75fea07abcefe4460197
https://pubmed.ncbi.nlm.nih.gov/28594553
https://pubmed.ncbi.nlm.nih.gov/28594553
Autor:
Kenichiro Shimokawa, Hiroshi Nara, Naoki Miyamoto, Takayuki Hattori, Mikihiko Naito, Tomoya Sameshima, Nobuo Cho, Norihito Shibata, Katsunori Nagai, Yasuhiro Imaeda, Nobumichi Ohoka
Publikováno v:
Cancer Science
Chromosomal translocation occurs in some cancer cells, which results in the expression of aberrant oncogenic fusion proteins that include BCR-ABL in chronic myelogenous leukemia (CML). Inhibitors of ABL tyrosine kinase, such as imatinib and dasatinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25722a914b2a007dc06e2bd77ee59299
https://pubmed.ncbi.nlm.nih.gov/28556300
https://pubmed.ncbi.nlm.nih.gov/28556300
Publikováno v:
Journal of Food Science. 66:1130-1136
Hemocyanin (Hc) from plasma of kuruma prawn was characterized as a potent inducer of black spots during storage. An oxygen transporter, hemocyanin was converted into phenoloxidase (PO)-like enzyme (HdPO) with SDS treatment as well as prophenoloxidase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32e72f6395a180e60f3b063ee00c1f5c
https://doi.org/10.1111/j.1365-2621.2001.tb16093.x
https://doi.org/10.1111/j.1365-2621.2001.tb16093.x
Effects of β-l, 3-glucan on the Activation of Prophenoloxidase Cascade in Penaeus japonicus Hemocyte
Publikováno v:
Fisheries science. 65:926-929
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2771b0cbda7d1b0911f26393a58fd5c
https://doi.org/10.2331/fishsci.65.926
https://doi.org/10.2331/fishsci.65.926
Autor:
Morihiko Sakaguchi, Satoshi Fujisawa, Takashi Hirata, Masato Kinoshita, Kohsuke Adachi, Katsunori Nagai
Publikováno v:
Fisheries science. 65:919-925
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e96a25d30a6af984bc2a8decb51b9188
https://doi.org/10.2331/fishsci.65.919
https://doi.org/10.2331/fishsci.65.919
Publikováno v:
Tetrahedron Letters. 38:7111-7114
A series of resin-bound 4-substituted-2-aminobutadienes have been synthesised via Wittig reaction with polymer supported 2-( N -piperazino)prop-1-enyl-1-triphenylphosphonium bromide. The use of piperazine provides a readily cleavable enamine linker f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3b1547f7bd8b3f990bca154706d13aa
https://doi.org/10.1016/s0040-4039(97)01633-x
https://doi.org/10.1016/s0040-4039(97)01633-x