Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Katsunori Maruta"'
Autor:
T. Goto, M. Yamanaka, R. Nagata, Makoto Takata, R. Nakayama, T. Takazawa, A. Tsuchida, Katsunori Maruta, K. Watanabe, H. Kato, Jun Nagamine
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 123:492-499
Aims/Introduction: Peroxisome proliferator-activated receptors (PPARs) play a key regulating role in homeostasis. In this study, we investigated the effects of DSP-8658, a novel selective PPARa/γ modulator, on adipogenesis and glucose metabolism in
Publikováno v:
Tetrahedron. 54:2401-2410
The acyclic ligands with an adjacent bistetrahydrofuran (THF) skeleton have been synthesized as analogs of bullatacin, a representative natural product in a family of Annonaceous acetogenins, and their binding properties toward metal cations have bee
Publikováno v:
Chemical and Pharmaceutical Bulletin. 46:154-158
We investigated the in vitro antitumor activities toward mouse and human cell lines of optically active synthetic bistetrahydrofuran (bis-THF) derivatives as analogs of Annonaceous acetogenins, which contain bis-THF, long unbranched alkyl chains, hyd
Autor:
Kazuhisa Hiratani, Katsunori Maruta, Shigeki Sasaki, Hideki Sugihara, Minoru Maeda, Hiroyuki Naito
Publikováno v:
Tetrahedron Letters. 36:5571-5574
New calcium-selective electrodes were prepared incorporating the natural products Annonaceous Acetogenins, (+)-squamocin G (bullatacin), (+)-squamocin H (asimicin) and their analogs with neighboring bistetrahydrofuran structures. They showed high Ca
Publikováno v:
The Journal of Organic Chemistry. 60:4419-4427
Publikováno v:
Tetrahedron Letters. 35:3337-3340
Hydroxylated bistetrahydrofuran derivatives which are structural components of potent antitumor Annonaceous acetogenins have been revealed to form supramolecular complexes with metal cations. In particular, 2b formed 2:1 ligand/metal complex with cal
Autor:
Atsushi Tsuchida, Kiyotaka Iwai, Katsunori Maruta, Jun Nagamine, Kantaro Ushiroda, Ryu Nagata, Mutsuo Taiji, Makoto Kitoh
Publikováno v:
ChemInform. 42
A series of benzoylpyrrole-based carboxylic acids are designed and synthesized as peroxisome proliferator-activated receptor (PPAR) activators.
Autor:
Yasuhiro Sato, Shinji Horai, Mutsuo Taiji, Katsunori Maruta, Kantaro Ushiroda, Kazunori Yanagi, Takeshi Takazawa, Tetsuya Kohno, Ryu Nagata, Tomokazu Nagano
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(7)
In our search for new PPARα/γ agonists, we designed and synthesized a series of benzoylazole-based carboxylic acids. Compound 9 showed potent PPARγ partial agonistic activity with modest PPARα agonistic activity. The sodium salt of 9 (9Na) demons
Autor:
Mutsuo Taiji, Ryu Nagata, Jun Nagamine, Makoto Kitoh, Katsunori Maruta, Kantaro Ushiroda, Kiyotaka Iwai, Atsushi Tsuchida
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(1)
Starting with a subtle blood glucose-lowering effect of a TGF-β inhibitor, we designed and synthesized a series of benzoylpyrrole-based carboxylic acids as PPARs activators. Among these compounds, 10sNa exhibited favorable blood glucose-lowering eff
Publikováno v:
ChemInform. 26