Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Katsumi Koike"'
Autor:
Naotake Kobayashi, Norihito Sato, Yuko Fujimura, Tsuyoshi Kihara, Katsuji Sugita, Kouji Takahashi, Katsumi Koike, Tamio Sugawara, Yukio Tada, Hiroshi Nakai, Takayoshi Yoshikawa
Publikováno v:
ACS Omega, Vol 3, Iss 10, Pp 13647-13666 (2018)
Externí odkaz:
https://doaj.org/article/d165d037b7464779bcf5a8df0d389a63
Autor:
Naotake Kobayashi, Norihito Sato, Yuko Fujimura, Tsuyoshi Kihara, Katsuji Sugita, Kouji Takahashi, Katsumi Koike, Tamio Sugawara, Yukio Tada, Hiroshi Nakai, Takayoshi Yoshikawa
Publikováno v:
ACS Omega, Vol 4, Iss 4, Pp 6977-6978 (2019)
Externí odkaz:
https://doaj.org/article/fdb4daf687f24bdebc282ea868c82a00
Autor:
Kazuhisa Minami, Minoru Hasegawa, Hisanori Ito, Atsushi Nakamura, Takako Tomii, Mitsunobu Matsumoto, Satoshi Orita, Syuichi Matsushima, Takako Miyoshi, Koichi Masuno, Mikinori Torii, Katsumi Koike, Shinji Shimada, Toshiyuki Kanemasa, Tsuyoshi Kihara, Minoru Narita, Tsutomu Suzuki, Akira Kato
Publikováno v:
Journal of Pharmacological Sciences, Vol 111, Iss 1, Pp 60-72 (2009)
Morphine, oxycodone, and fentanyl are clinically prescribed drugs for the management of severe pain. We investigated whether these opioids possess different efficacy profiles on several types of pain in mouse pain models. When the three opioids were
Externí odkaz:
https://doaj.org/article/008c1894dc1248a68fb930e82144eebf
Autor:
Tsutomu Suzuki, Hirokazu Mishima, Mika Kobayashi, Masahide Fujita, Yasuhide Morioka, Motoji Kitaura, Katsumi Koike, Kana Yasufuku, Shino Takenouchi, Hiroki Chiba, Minoru Hasegawa
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1746-1751
Tramadol is a weak opioid that produces analgesic effect via both the μ-opioid receptor (MOR) and non-opioid targets. Constipation is the most common opioid-related side effect in patients with cancer and non-cancer pain. However, the contribution o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c7fe057133b447f920b4b3b40698f4
https://doi.org/10.1248/bpb.b21-00474
https://doi.org/10.1248/bpb.b21-00474
Autor:
Norihito Sato, Tamio Sugawara, Tsuyoshi Kihara, Katsumi Koike, Takayoshi Yoshikawa, Naotake Kobayashi, Katsuji Sugita, Yukio Tada
Publikováno v:
Chemical and Pharmaceutical Bulletin. 69:314-324
We explored orally effective thyrotropin-releasing hormone (TRH) mimetics, which show high central nervous system effects in structure-activity relationship studies based on in vivo antagonistic activity on reserpine-induced hypothermia (anti-hypothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa00aa382cc9f9171b9a5d969fdab8ef
https://doi.org/10.1248/cpb.c20-00454
https://doi.org/10.1248/cpb.c20-00454
Autor:
Katsumi Koike, Tohko Arai, Atsushi Nakamura, Minoru Hasegawa, Kenji Takase, Yasuhide Morioka, Toshiyuki Kanemasa
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 373:438-444
Opioid-induced constipation (OIC), a typical side effect of opioids, is due to activation of the μ-opioid receptors in the enteric nervous system. Peripherally acting μ-opioid receptor antagonists (PAMORAs) can reverse OIC by inhibiting the periphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63bc20d07c653f66f6ffa2e376dd69f0
https://doi.org/10.1124/jpet.119.264515
https://doi.org/10.1124/jpet.119.264515
Autor:
Shin-Ichiro Hara, Yoshinori Tamura, Shuuichi Oonishi, Yoshihisa Goto, Masanao Inagaki, Nobuhiro Haga, Hiroyuki Kai, Katsumi Koike, Tsuyoshi Hasegawa, Takashi Nakamura, Masaharu Kume, Toshiyuki Kanemasa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:73-77
Structure-activity relationship studies of several morphinan derivatives were conducted to obtain dual antagonists for μ- and δ-opioid receptors. We discovered peripherally restricted dual antagonists for μ/δ-opioid receptors as a new chemotype w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c26b52203a2e18c5ba1611affa36e56
https://doi.org/10.1016/j.bmcl.2018.11.007
https://doi.org/10.1016/j.bmcl.2018.11.007
Autor:
Naotake, Kobayashi, Norihito, Sato, Katsuji, Sugita, Tsuyoshi, Kihara, Katsumi, Koike, Tamio, Sugawara, Yukio, Tada, Takayoshi, Yoshikawa
Publikováno v:
Chemicalpharmaceutical bulletin. 69(4)
We explored orally effective thyrotropin-releasing hormone (TRH) mimetics, which show high central nervous system effects in structure-activity relationship studies based on in vivo antagonistic activity on reserpine-induced hypothermia (anti-hypothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27807454b6f03b797a0764f4082b89f8
https://pubmed.ncbi.nlm.nih.gov/33790077
https://pubmed.ncbi.nlm.nih.gov/33790077
Autor:
Takanobu Matsuzaki, Youko Furue, Kana Yasufuku, Tomoko Matsumoto, Mami Muramoto, Hiroyuki Aritomi, Hiroki Chiba, Toshiyuki Kanemasa, Katsumi Koike, Ryosuke Watari, Tomoka Shimada, Masahide Fujita, Shinji Shimada, Atsushi Nakamura, Toshiyuki Asaki, Kenji Takase
Publikováno v:
Neuroscience letters. 735
Naloxone is a μ-opioid receptor antagonist that has been used to prevent overdose-related respiratory depression and deaths by the illicit use of opioids. Naloxone can also deter the abuse potential of opioids, but little has been reported regarding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8c7d200855cb10bb598c56e3f48d25
https://pubmed.ncbi.nlm.nih.gov/32569809
https://pubmed.ncbi.nlm.nih.gov/32569809
Autor:
Toshiyuki, Kanemasa, Katsumi, Koike, Kenji, Takase, Tohko, Arai, Atsushi, Nakamura, Yasuhide, Morioka, Minoru, Hasegawa
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 373(3)
Opioid-induced constipation (OIC), a typical side effect of opioids, is due to activation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d70348197c26ac4719efe4fe564ad86b
https://pubmed.ncbi.nlm.nih.gov/32169839
https://pubmed.ncbi.nlm.nih.gov/32169839