Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Katsumi Aragane"'
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 4, Pp 480-488 (2001)
Acyl-CoA:cholesterol acyltransferase (ACAT) is thought to contribute significantly to lipid deposition in macrophages, which subsequently leads to the initiation and progression of atherosclerosis. The aim of the present study was to examine the infl
Externí odkaz:
https://doaj.org/article/e293b30071094b3399e5056eb6dccf05
Publikováno v:
YAKUGAKU ZASSHI. 134:203-211
Global spread of counterfeit medicines is an imminent threat for the patients' safety. Although major targets of counterfeits are still erectile dysfunction (ED) drugs in the industrialized countries, including Japan, anti-cancer agents and some medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bad390fb547ff3986e86bc3ec27629
https://doi.org/10.1248/yakushi.13-00230-2
https://doi.org/10.1248/yakushi.13-00230-2
Autor:
Ken Shimamura, Katsumi Aragane, Toshiyuki Takahashi, Maki Kanesaka, Yasuhisa Miyamoto, Shigeru Tokita, Takahide Sasaki, Tsuyoshi Nagase, Ryo Yoshimoto, Hidefumi Kitazawa, Nagaaki Sato, Akira Nagumo
Publikováno v:
Journal of Medicinal Chemistry. 52:4111-4114
Long chain fatty acid elongase 6 (ELOVL6) catalyzes the elongation of long chain fatty acyl-CoAs and is a potential target for the treatment of metabolic disorders. The ultrahigh throughput screen of our corporate chemical collections resulted in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0464844a9a0dc51ceb1eda04f4e37e2b
https://doi.org/10.1021/jm900488k
https://doi.org/10.1021/jm900488k
Autor:
Koji Fujinami, Yoshitaka Tamai, Katsumi Aragane, Kenji Ohwaki, Zenjun Oda, Mari Yonemoto, Yuika Ikeda, Mayumi Okawa, Katsuya Ohbuchi, Naomoto Harada, Yoshikazu Hara, Jun Kusunoki
Publikováno v:
Molecular and Cellular Biology. 27:1881-1888
Acetyl coenzyme A (acetyl-CoA) carboxylase (ACC) catalyzes carboxylation of acetyl-CoA to form malonyl-CoA. In mammals, two isozymes exist with distinct physiological roles: cytosolic ACC1 participates in de novo lipogenesis (DNL), and mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf60779f34350c9dc656dec11d6441b
https://doi.org/10.1128/mcb.01122-06
https://doi.org/10.1128/mcb.01122-06
Publikováno v:
Atherosclerosis. 158:139-145
Cholesterol-fed rabbits were used to study the anti-atherosclerotic effect of (1S ,2 S)-2-[3-(2,2-dimethylpropyl)-3-nonylureido]cyclohexane-1-yl 3-[(4R)-N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (F-1394), an acylCoA:cholesterol a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3943529576f9e1773f2a4d9e7ea95ef6
https://doi.org/10.1016/s0021-9150(01)00441-5
https://doi.org/10.1016/s0021-9150(01)00441-5
Autor:
Koji Fujinami, Katsumi Aragane, Tsuyoshi Chiwata, Nobuhiro Yamada, Shun Ishibashi, Jun Kusunoki, Kazuhiro Kojima
Publikováno v:
British Journal of Pharmacology. 133:1005-1012
1 The acyl-CoA:cholesterol acyltransferase (ACAT) enzyme is thought to be responsible for foam cell formation and the subsequent progression of atherosclerosis. The apolipoprotein E and low density lipoprotein receptor double knockout (apoE/LDLr-DKO)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da5434bab483d671455ed9374456da7a
https://doi.org/10.1038/sj.bjp.0704160
https://doi.org/10.1038/sj.bjp.0704160
Autor:
Kaoru Takemura, Yoji Fukuda, Masato Ishigami, Tohru Funahashi, Yuji Matsuzawa, Natsuki Nakayama, Iichiro Shimomura, Kiyotaka Toide, Hiroshi Kuriyama, Marie C. Lin, Katsumi Aragane, Zhi-Wei Man, John R. Wetterau, Shizuya Yamashita, Tadashi Nakamura, Kouji Miyaoka
Publikováno v:
Hepatology. 27:557-562
The liver plays a central role in lipoprotein metabolism. In particular, very-low density lipoprotein (VLDL) is assembled in the hepatocytes and secreted into the blood circulation. The VLDL is then catabolized to low-density lipoprotein by lipoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7883e265675c4057df597da513a3e11d
https://doi.org/10.1002/hep.510270233
https://doi.org/10.1002/hep.510270233
Publikováno v:
Japanese Journal of Pharmacology. 76:309-312
We examined the inhibitory potency of F-1394 ((lS,2S)-2-[3-(2,2-dimethylpropyl)-3-nonylureido]cyclohexane-1-yl 3-[(4R)-N(2,2,5,5-tetramethyl-l,3-dioxane-4-carbonyl)amino]propionate), an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on ACAT a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b333a7af50b06dd62017c52ff530332
https://doi.org/10.1254/jjp.76.309
https://doi.org/10.1254/jjp.76.309
Autor:
Sakiko Higashinakagawa, Haruo Ohnishi, Noriko Kase, Tetsuya Kitamine, Katsumi Aragane, Jun Kusunoki, Tetsuaki Yamaura
Publikováno v:
Japanese Journal of Pharmacology. 69:53-60
In the present study, we investigated the hypocholesterolemic effect of F-1394 ((1s,2s)-2-[3-(2,2-dimethylpropyl)-3-nonylureido]aminocyclohexane-1-yl 3-|N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate), a potent and selective inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5613122778a6e2b35e2d120464c150c2
https://doi.org/10.1254/jjp.69.53
https://doi.org/10.1254/jjp.69.53
Autor:
Yasuhisa Miyamoto, Ken Shimamura, Hidefumi Kitazawa, Naomi Morita, Shigeru Tokita, Katsumi Aragane, Toshiyuki Takahashi, Tomoyuki Ohe, Nagaaki Sato, Ryo Yoshimoto, Tsuyoshi Nagase, Maki Kanesaka, Akira Nagumo
Publikováno v:
European journal of pharmacology. 630(1-3)
The elongase of long chain fatty acids family 6 (ELOVL6) is a rate-limiting enzyme for the elongation of saturated and monounsaturated long chain fatty acids. ELOVL6 is abundantly expressed in lipogenic tissues such as liver, and its mRNA expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5964cf4f3326a726a3f491c4666a977
https://pubmed.ncbi.nlm.nih.gov/20045404
https://pubmed.ncbi.nlm.nih.gov/20045404