Výsledky vyhledávání - "Katsumasa Otake"

TP0586532, a non-hydroxamate LpxC inhibitor, has in vitro and in vivo antibacterial activities against Enterobacteriaceae

Autor: Iichiro Takata, Hirotoshi Okumura, Hajime Takashima, Ippei Yoshida, Kiyoko Fujita, Katsumasa Otake, Hiroyuki Sugiyama

Publikováno v: The Journal of Antibiotics. 75:98-107

The emergence of multi-drug resistant pathogenic bacteria, especially Gram-negative bacteria, is a worldwide health problem. New antibiotics directed at previously unexplored targets are urgently needed to overcome resistance to existing antibiotic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d4f315486cc65b6828958fa6b0a6ca
https://doi.org/10.1038/s41429-021-00486-3

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Pharmacodynamic target assessment and prediction of clinically effective dosing regimen of TP0586532, a novel non-hydroxamate LpxC inhibitor, using a murine lung infection model

Autor: Kiyoko Fujita, Iichiro Takata, Ippei Yoshida, Yusuke Honma, Hirotoshi Okumura, Katsumasa Otake, Hajime Takashima, Hiroyuki Sugiyama

Publikováno v: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 28(5)

TP0586532 is a novel non-hydroxamate UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) inhibitor. Pharmacokinetic/pharmacodynamic (PK/PD) indices and magnitude of index that correlated with the efficacy of TP0586532 were determined and used to esti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9d16cbdb0a7da71cbe67c5dcdb4911
https://pubmed.ncbi.nlm.nih.gov/35131156

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Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo [b]thiophene derivatives as gut-selective NaPi2b inhibitors

Autor: Yasunobu Ushiki, Kenichi Kawabe, Kumiko Yamamoto-Okada, Fumito Uneuchi, Yuta Asanuma, Chitose Yamaguchi, Hiroshi Ohta, Tsuyoshi Shibata, Tomohiro Abe, Lisa Okumura-Kitajima, Yuki Kosai, Mayumi Endo, Katsumasa Otake, Eiji Munetomo, Teisuke Takahashi, Hiroyuki Kakinuma

Publikováno v: Bioorganicmedicinal chemistry letters. 59

Intestinal sodium-dependent phosphate transport protein 2b (SLC34A2, NaPi2b) inhibitors are expected to be potential new candidates for anti-hyperphosphatemia drugs. However, a risk of on-target side effects based on the inhibition of NaPi2b in the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a0b1288f54af8bcf75b3a07f0e21c4
https://pubmed.ncbi.nlm.nih.gov/35066140

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Design, synthesis and biological evaluation of novel indole derivatives as gut-selective NaPi2b inhibitors

Autor: Yasunobu, Ushiki, Kenichi, Kawabe, Kumiko, Yamamoto-Okada, Fumito, Uneuchi, Yuta, Asanuma, Chitose, Yamaguchi, Hiroshi, Ohta, Tsuyoshi, Shibata, Tomohiro, Abe, Lisa, Okumura-Kitajima, Yuki, Kosai, Mayumi, Endo, Katsumasa, Otake, Eiji, Munetomo, Teisuke, Takahashi, Hiroyuki, Kakinuma

Publikováno v: Bioorganic & Medicinal Chemistry. 66:116783

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb4cd0896c30a607f0687d651be2291
https://doi.org/10.1016/j.bmc.2022.116783

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Design, synthesis and biological evaluation of novel pyridine derivatives as gut-selective NaPi2b inhibitors

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 65:128700

We previously reported thiophene derivatives as gut-selective (minimally systemic) and potent sodium-dependent phosphate transport protein 2b (SLC34A2, NaPi2b) inhibitors. However, these derivatives did not suppress phosphate absorption form the inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042ae16f3d6bd5911bf0834ec8fa3dd9
https://doi.org/10.1016/j.bmcl.2022.128700

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Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532

Autor: Yuya Ogata, Nozomi Tanaka-Yamamoto, Naoki Sasamoto, Iichiro Takata, Katsumasa Otake, Hajime Takashima, Yohei Matsuda, Haruhiro Yamashita, Mayumi Endo, Kiyoko Fujita, Kaori Ueki, Masashi Mima, Satoshi Tsuji, Hirotoshi Okumura, Hiroyuki Sugiyama, Fumihito Ushiyama, Risa Kurimoto-Tsuruta

Publikováno v: Bioorganicmedicinal chemistry. 30

Infectious diseases caused by resistant Gram-negative bacteria have become a serious problem, and the development of therapeutic drugs with a novel mechanism of action and that do not exhibit cross-resistance with existing drugs has been earnestly de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5917a1ea67529b22ac1ee7b5021a36ec
https://pubmed.ncbi.nlm.nih.gov/33385955

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Improved Intestinal Membrane Permeability of Hexose-Quinoline Derivatives via the Hexose Transporter, SGLT1

Autor: Thomas J. Cook, Ikumi Tamai, Hikaru Yabuuchi, Katsumasa Otake, Tomoji Maeda, Hiroshi Suzuki, Makoto Haga, Ryunosuke Higashi

Publikováno v: Journal of Pharmaceutical Sciences. 97:1821-1830

Intestinal membrane permeability is an important factor affecting the bioavailability of drugs. As a strategy to improve membrane permeability, membrane transporters are useful targets since essential nutrients are absorbed efficiently via specific t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5a08a772ecd84371fe66c7c6184e29
https://doi.org/10.1002/jps.21147

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Effect of ultraviolet absorbing agents on photodegradation behavior of a disperse dye

Autor: Toru Takagishi, Nobuyuki Katsuda, Takashi Omura, Katsumasa Otake

Publikováno v: Dyes and Pigments. 36:193-204

The action and effect of ultraviolet absorbing agents (UV A) on the photofading of dyed fiber, in particular polyester, were investigated using a monochromatic light source. Polyester fiber itself and the dyed fiber were affected markedly by spectroi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77d2096cdd3812cb054ef366e89aceb1
https://doi.org/10.1016/s0143-7208(97)00003-x

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Photodegradation of a disperse dye on polyester fiber and in solution

Autor: Toru Takagishi, Takashi Omura, Nobuyuki Katsuda, Katsumasa Otake, Shinnichi Yabushita

Publikováno v: Dyes and Pigments. 31:291-300

The photodegradation behavior of dyes on fibers such as nylon, cotton fibers, and in particular, polyester, and in a solution has been investigated. The undyed and dyed fibers were irradiated with monochromatic light of various wavelengths. The light

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba85cfc06aeec563acc67a387f54dabe
https://doi.org/10.1016/0143-7208(96)00012-5

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Bromine Addition to Rotameric 1-(9-Fluorenyl)-2-(1-methylvinyl)naphthalene. Fate of Intermediate Cations Produced by Bromine Cation Attack

Autor: Shinji Toyota, Katsumasa Otake, Masaru Ono, Katsumi Shionoiri, Michinori Oki

Publikováno v: Chemistry Letters. 20:597-600

Treatment of the rotamers of the title compound with bromine afforded a normal addition compound in the case of ap, whereas the sp rotamer did bromo-olefins and a cyclic compound only. The results are discussed on the basis of the steric effects and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2b3b4b0a2f56f723c116f45a0689e2e
https://doi.org/10.1246/cl.1991.597

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