Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Katsumasa Nakajima"'
Autor:
Zainab Jagani, Deborah Castelletti, Hyo-eun C. Bhang, David A. Ruddy, Audrey Kauffmann, Julien P.N. Papillon, Troy Smith, Rukundo Ntaganda, Simon Mathieu, Christopher D. Adair, Katsumasa Nakajima, Henrik Möbitz, Anthony Vattay, Anka Bric, Matthew D. Shirley, Yun Feng, Geoffrey Bushold, Kay X. Xiang, Ali Farsidjani, Julie T. Chen, Dorothee Abramowski, Aurore Desplat, Grainne Kerr, Kathleen Sprouffske, Ailing Li, GiNell Elliott, Florencia Rago
Additional method details for ATAC-Seq Data Analysis and ChIP-qPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667bbae7f1dda626aef222d2078505f7
https://doi.org/10.1158/1535-7163.22519459
https://doi.org/10.1158/1535-7163.22519459
Autor:
Zainab Jagani, Deborah Castelletti, Hyo-eun C. Bhang, David A. Ruddy, Audrey Kauffmann, Julien P.N. Papillon, Troy Smith, Rukundo Ntaganda, Simon Mathieu, Christopher D. Adair, Katsumasa Nakajima, Henrik Möbitz, Anthony Vattay, Anka Bric, Matthew D. Shirley, Yun Feng, Geoffrey Bushold, Kay X. Xiang, Ali Farsidjani, Julie T. Chen, Dorothee Abramowski, Aurore Desplat, Grainne Kerr, Kathleen Sprouffske, Ailing Li, GiNell Elliott, Florencia Rago
Supplementary Table S1 lists biochemical and cellular activity of BRG1/BRM inhibitors. Supplementary Table S2 lists BRM011 and BRM014 activity across cell line panel. Supplementary Table S3 lists cell lines generated for this study. Supplementary Tab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ff6df114c3445da1491dc2bf68ac80
https://doi.org/10.1158/1535-7163.22519456
https://doi.org/10.1158/1535-7163.22519456
Autor:
Zainab Jagani, Deborah Castelletti, Hyo-eun C. Bhang, David A. Ruddy, Audrey Kauffmann, Julien P.N. Papillon, Troy Smith, Rukundo Ntaganda, Simon Mathieu, Christopher D. Adair, Katsumasa Nakajima, Henrik Möbitz, Anthony Vattay, Anka Bric, Matthew D. Shirley, Yun Feng, Geoffrey Bushold, Kay X. Xiang, Ali Farsidjani, Julie T. Chen, Dorothee Abramowski, Aurore Desplat, Grainne Kerr, Kathleen Sprouffske, Ailing Li, GiNell Elliott, Florencia Rago
Supplementary Figure S1 shows additional shRNA knockdown data in uveal melanoma cell lines. Supplementary Figure S2 shows additional dual BRG1/BRM knockdown data and BRG1 rescue data. Supplementary Figure S3 shows basal SWI/SNF subunit expression, ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54896da058f0b4949ae1ea1abc687f7e
https://doi.org/10.1158/1535-7163.22519462.v1
https://doi.org/10.1158/1535-7163.22519462.v1
Autor:
Christian M. Gampe, Jingzhou Li, Patel Tajesh Jayprakash, Jakal Amin, Charles Babu, Lihua Yang, Eugene Liu, Andrei Golosov, Katsumasa Nakajima, David Nettleton, Patrick C. Reid, Lauren G. Monovich, Flyer Alec
Publikováno v:
Journal of Medicinal Chemistry. 64:2622-2633
Advances in the design of permeable peptides and in the synthesis of large arrays of macrocyclic peptides with diverse amino acids have evolved on parallel but independent tracks. Less precedent combines their respective attributes, thereby limiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dd9795db77b2153f204b31c1dd80d9
https://doi.org/10.1021/acs.jmedchem.0c01505
https://doi.org/10.1021/acs.jmedchem.0c01505
Autor:
Matthew D. Shirley, Julie T. Chen, Ailing Li, Anthony Vattay, David A. Ruddy, Anka Bric, Kay X. Xiang, Simon Mathieu, Troy Smith, Julien Papillon, Deborah Castelletti, Rukundo Ntaganda, Kathleen Sprouffske, Hyo-eun C. Bhang, Yun Feng, Dorothee Abramowski, Ali Farsidjani, Audrey Kauffmann, Grainne Kerr, Aurore Desplat, Geoffrey Bushold, Katsumasa Nakajima, Henrik Möbitz, GiNell Elliott, Christopher D. Adair, Zainab Jagani, Florencia Rago
Publikováno v:
Molecular Cancer Therapeutics. 19:2186-2195
Uveal melanoma is a rare and aggressive cancer that originates in the eye. Currently, there are no approved targeted therapies and very few effective treatments for this cancer. Although activating mutations in the G protein alpha subunits, GNAQ and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834a4bf4bd6c499cad099714441dcd05
https://doi.org/10.1158/1535-7163.mct-19-1013
https://doi.org/10.1158/1535-7163.mct-19-1013
Autor:
Margaret E Brousseau, Kevin B Clairmont, Glen Spraggon, Alec N Flyer, Andrei A Golosov, Philipp Grosche, Jérôme André, Shari Caplan, Guanjing Chen, Li Fan, Raphael Gattlen, Alexander Koch, Ian Lewis, Jingzhou Li, Eugene Liu, Danuta Lubicka, Andreas Marzinzik, Katsumasa Nakajima, David Nettleton, Johannes Ottl, Meihui Pan, Tajesh Patel, Stephanie Pickett, Jennifer Poirier, Patrick C Reid, Xavier Pelle, Vanitha Subramanian, Victoria Vera, Mei Xu, Lihua Yang, Qing Yang, jinghua yu, Guoming Zhu, Lauren G Monovich
Publikováno v:
Circulation. 144
Elevated LDL-C is a major risk factor for atherosclerotic cardiovascular disease, the leading cause of death worldwide. Proprotein convertase subtilisin/kexin type 9 (PCSK9) has pronounced effects on LDL-C levels via its modulation of hepatic LDL rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c41fa5183540594ef99cce950597f62
https://doi.org/10.1161/circ.144.suppl_1.10516
https://doi.org/10.1161/circ.144.suppl_1.10516
Autor:
Katsumasa Nakajima, David Nettleton, Guoming Zhu, Debra Burdick, Alexander W. Koch, Qing Yang, Glen Spraggon, Margaret E. Brousseau, Guanjing Chen, Lisa Ames, Raphael Gattlen, Flyer Alec, Jennifer Poirier, Jingzhou Li, Mohindra Seepersaud, Dawn Kelly-Sullivan, Stephanie Pickett, Xavier Pelle, Lauren Perry, Raj Chopra, Jakal Amin, Jerome Andre, Danuta Lubicka, Victoria Vera, Philipp Grosche, Patel Tajesh Jayprakash, Ian Lewis, Lihua Yang, Eugene Liu, Andrei Golosov, jinghua yu, Li Fan, Patrick C. Reid, Lauren G. Monovich, Shari L. Caplan, Meihui Pan, Diana Dubiel, Vanitha Subramanian, Kevin B. Clairmont, Johannes Ottl, Mei Xu, Andreas Marzinzik
Publikováno v:
Cell Chemical Biology. 29:249-258.e5
Summary Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promoting hepatic LDL receptor (LDLR) degradation. Therapeutic antibodies that disrupt PCSK9-LDLR binding reduce LDL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b646053b683b9aba0f84b9efef17df
https://doi.org/10.1016/j.chembiol.2021.08.012
https://doi.org/10.1016/j.chembiol.2021.08.012
Autor:
Julien Papillon, Rajeshri Ganesh Karki, Gregg Chenail, Zainab Jagani, Raviraj Kulathila, Xiaoling Xie, Henrik Möbitz, John Cantwell, Tiancen Hu, Xiaoping Zhu, Felipe Kellermann Hurtado, Tamara J. Gilbert, Anthony Vattay, Daniel King, Hyo-eun C. Bhang, Emily A. Costa, Katsumasa Nakajima, Susan E. Hill, Q. Kimberley Yue, Catherine Luu, Rukundo Ntaganda, Christopher D. Adair, Michael Scott Visser, Jonathan E. Hempel, David Farley, Ailing Li, Anka Bric, Simon Mathieu, Troy Smith, Geoffrey Bushold, Eugen Lounkine, Andriana Jouk, Isabel Park, Katarina Vulic, Kay Xiang, Julie Dooley
Publikováno v:
Journal of Medicinal Chemistry. 61:10155-10172
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2), also known as Brahma homologue (BRM), is a Snf2-family DNA-dependent ATPase. BRM and its close homologue Brahma-related gene 1 (BRG1), also kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82980a2b96152a3795980e644fee3da5
https://doi.org/10.1021/acs.jmedchem.8b01318
https://doi.org/10.1021/acs.jmedchem.8b01318
Autor:
Michael H. Serrano-Wu, Alan D. Neubert, Katsumasa Nakajima, Jingzhou Li, Qing Yang, David Truong, Kevin B. Clairmont, Renee Commerford, Aaron Kanter, Thomas Daniels, Young-Shin Kwak, Paul V. Szklennik, Yongjin Gong, Vivienne Tedesco, Gary M. Coppola, Brian K. Hubbard, Ricardo E. Chatelain, Thomas A. Gilmore, Charles D. Meyers, Forster Cornelia J, Monish Jain, James Thompson
Publikováno v:
Journal of medicinal chemistry. 60(11)
Modification of a gut restricted class of benzimidazole DGAT1 inhibitor 1 led to 9 with good oral bioavailability. The key structural changes to 1 include bioisosteric replacement of the amide with oxadiazole and α,α-dimethylation of the carboxylic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa6137e12579f36a972ee08d1ca7bc6
https://pubmed.ncbi.nlm.nih.gov/28498655
https://pubmed.ncbi.nlm.nih.gov/28498655
Publikováno v:
The Journal of Organic Chemistry. 73:4630-4637
Tertiary acyclic allyl amines and tertiary cyclic alpha-vinyl amines undergo conjugate additions to acetylenic sulfones to produce zwitterion intermediates, followed by 3-aza-Cope rearrangements. In the case of cyclic alpha-vinyl amines, the process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cdfcf16153e6f9cf72bae132b5c00f
https://doi.org/10.1021/jo800600a
https://doi.org/10.1021/jo800600a