Bone regeneration of induced pluripotent stem cells derived from peripheral blood cells in collagen sponge scaffolds

Autor: Hiroshi Kato, Katsuhito Watanabe, Akiko Saito, Shoko Onodera, Toshifumi Azuma, Masayuki Takano

Publikováno v: Journal of Applied Oral Science, Vol 30 (2022)

Abstract Stem cell-based regeneration therapy offers new therapeutic options for patients with bone defects because of significant advances in stem cell research. Although bone marrow mesenchymal stem cells are the ideal material for bone regeneratio

Externí odkaz: https://doaj.org/article/73f34298c649402c94deb8ddd77051bb

Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia improves bone regeneration in a rat calvarial bone defect model

Autor: Akiko Saito, Akio Ooki, Takashi Nakamura, Shoko Onodera, Kamichika Hayashi, Daigo Hasegawa, Takahito Okudaira, Katsuhito Watanabe, Hiroshi Kato, Takeshi Onda, Akira Watanabe, Kenjiro Kosaki, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Teruo Sakamoto, Akira Yamaguchi, Kenji Sueishi, Toshifumi Azuma

Publikováno v: Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-10 (2018)

Abstract Background Runt-related transcription factor 2 (RUNX2) haploinsufficiency causes cleidocranial dysplasia (CCD) which is characterized by supernumerary teeth, short stature, clavicular dysplasia, and osteoporosis. At present, as a therapeutic

Externí odkaz: https://doaj.org/article/ce9b936bf4274cf0a5bc559c3dec8416

Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.

Autor: Daigo Hasegawa, Hiromi Ochiai-Shino, Shoko Onodera, Takashi Nakamura, Akiko Saito, Takeshi Onda, Katsuhito Watanabe, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Kenjiro Kosaki, Akira Yamaguchi, Takahiko Shibahara, Toshifumi Azuma

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0186879 (2017)

Gorlin syndrome is an autosomal dominant inherited syndrome that predisposes a patient to the formation of basal cell carcinomas, odontogenic keratocysts, and skeletal anomalies. Causative mutations in several genes associated with the sonic hedgehog

Externí odkaz: https://doaj.org/article/de56c70d98ea4d51b1043a0339cbac90

Bone regeneration of induced pluripotent stem cells derived from peripheral blood cells in collagen sponge scaffolds

Autor: Hiroshi Kato, Katsuhito Watanabe, Akiko Saito, Shoko Onodera, Toshifumi Azuma, Masayuki Takano

Publikováno v: Journal of Applied Oral Science, Volume: 30, Article number: e20210491, Published: 21 FEB 2022
Journal of Applied Oral Science v.30 2022
Journal of applied oral science
Universidade de São Paulo (USP)
instacron:USP

Stem cell-based regeneration therapy offers new therapeutic options for patients with bone defects because of significant advances in stem cell research. Although bone marrow mesenchymal stem cells are the ideal material for bone regeneration therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2ea75b657ff5779e418b055e96ea7e
https://pubmed.ncbi.nlm.nih.gov/35195151

Heat shock protein 90 as a molecular target for therapy in oral squamous cell carcinoma: Inhibitory effects of 17‑DMAG and ganetespib on tumor cells

Autor: Shoichi Sekikawa, Takahiko Shibahara, Naoki Shiraishi, Katsuhito Watanabe, Takeshi Onda, Kaoru Onidani, Kamichika Hayashi

Publikováno v: Oncology reports. 45(2)

Heat shock protein 90 (HSP90) expression is upregulated in numerous types of cancer. However, its role as a candidate for molecular targeted therapy in oral squamous cell carcinoma (OSCC) cells is poorly understood. In the present study, a common ups

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688e4ef5d7049090e95767b014cb30cf
https://pubmed.ncbi.nlm.nih.gov/33416122