Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Katsuhito Nagai"'
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0291822 (2023)
BackgroundMenthol exerts relaxing, antibacterial, and anti-inflammatory activities, and is marketed as a functional food and therapeutic drug.AimIn the present study, the effects of menthol on the expression of multidrug resistance associated protein
Externí odkaz:
https://doaj.org/article/5b40ce8d160e4fd3bc20b8d2008cd278
Autor:
Mai Aoe, Seiji Esaki, Masahiro Ikejiri, Takuya Ito, Katsuhito Nagai, Yasutoshi Hatsuda, Yoshimi Hirokawa, Tomohisa Yasuhara, Takehiko Kenzaka, Toru Nishinaka
Publikováno v:
Pharmacy, Vol 11, Iss 1, p 16 (2023)
During the coronavirus disease 2019 (COVID-19) pandemic, online-based learning has become mainstream in many countries, and its learning outcomes have been evaluated. However, various studies have shown that online-based learning needs to be optimize
Externí odkaz:
https://doaj.org/article/51fa969e345c45258186cba1e0224695
Autor:
Katsuhito Nagai, Yoshikazu Ryuno, Yoshihito Iwanami, Sachiko Omotani, Shuhei Fukuno, Yasutoshi Hatsuda, Hiroki Konishi, Michiaki Myotoku
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Background The use of enteral nutrients plays a highly important role in accurate nutrition management, but limited information is currently available on the cautionary points of semi-solid enteral nutrients. Aim In this study, we examined whether th
Externí odkaz:
https://doaj.org/article/986472829df2464881bbc5ab064a2a6a
Publikováno v:
Anticancer research. 41(12)
Background/aim Epirubicin (EPI), an epimer of doxorubicin (DOX), and DOX are anthracycline agents with broad-spectrum antitumor activity. The aim of the present study was to elucidate the transport characteristics of EPI and DOX in human hepatocellul
Autor:
Shuhei Fukuno, Katsuhito Nagai, Shizuka Yamaoka, Fuka Yamada, Haruna Mizumoto, Takuya Ito, Hiroki Konishi
Publikováno v:
The Journal of pharmacy and pharmacology. 74(2)
Objectives We investigated the pharmacokinetic interaction of doxorubicin (DOX) with phenytoin (PHT) and the underlying mechanism in rats to clarify why the serum PHT concentration decreases despite the impaired PHT metabolic capacity in patients rec
Publikováno v:
Xenobiotica. 49:1470-1477
1. 5-Fluorouracil (5-FU) is a pyrimidine derivative widely used for the treatment of cancer. In this study, we investigated the effects of 5-FU on the protein expression of hepatic CYP3A and their enzyme activity for metabolizing midazolam (MDZ), a t
Autor:
Ikumi Nishimura, Hitomi Teramachi, Junji Mukai, Akihide Kobayashi, Michiaki Myotoku, Sachiko Omotani, Akihiko Ito, Katsuhito Nagai, Yasutoshi Hatsuda, Masahito Shibano
Publikováno v:
International Journal of Medical Sciences
The use of semi-solid enteral nutrients plays an extremely important role in accurate nutrition management. In the present study, we compared the pharmacokinetic profile of orally administered carbamazepine (CBZ) in rats treated with liquid RACOL®,
Autor:
Yasutoshi Hatsuda, Katsuhito Nagai, Sachiko Omotani, Michiaki Myotoku, Shuhei Fukuno, Yoshikazu Ryuno, Yoshihito Iwanami, Hiroki Konishi
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0259400 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0259400 (2021)
BackgroundThe use of enteral nutrients plays a highly important role in accurate nutrition management, but limited information is currently available on the cautionary points of semi-solid enteral nutrients.AimIn this study, we examined whether the p
Publikováno v:
Biopharmaceutics & Drug Disposition. 39:321-327
As there are to be known gender differences in the expression profiles of rat hepatic CYP2C, we examined the pharmacokinetic behavior of tolbutamide (TB), a typical probe for CYP2C, and hepatic enzyme activities for metabolizing TB in female rats to
Autor:
Yoshiki Nagamine, Hiroki Konishi, Keisuke Otani, Sachiko Omotani, Shuhei Fukuno, Yasutoshi Hatsuda, Michiaki Myotoku, Katsuhito Nagai
Publikováno v:
Pharmacology. 101:219-224
Doxorubicin (DOX) is a highly potent anti-neoplastic agent widely used in clinical practice, but its dosage and duration of administration are strictly limited due to dose-related organ damage. In the present study, we examined whether theanine, an a