Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Katsuhisa Inoue"'
Autor:
Yuta Funai, Kazuki Ichijo, Satoru Suzuki, Yuta Tateishi, Katsuhisa Inoue, Ikumi Tamai, Yoshiyuki Shirasaka
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The drug absorption profile is dependent on the luminal drug concentration, which in turn is influenced by the gastrointestinal (GI) fluid dynamics. In the present study, therefore, we aimed to examine the luminal fluid dynamics by kinetical
Externí odkaz:
https://doaj.org/article/833af25749354e72abe148e39219dc19
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0306058 (2024)
Mucosal-delivered drugs have to pass through the mucus layer before absorption through the epithelial cell membrane. Although there has been increasing interest in polymeric mucins, a major structural component of mucus, potentially acting as importa
Externí odkaz:
https://doaj.org/article/976c5176187a41b4a60b30cdc424519b
Autor:
Kei Higuchi, Misato Kunieda, Koki Sugiyama, Ryuto Tomabechi, Hisanao Kishimoto, Katsuhisa Inoue
Publikováno v:
Nutrients, Vol 15, Iss 16, p 3527 (2023)
SLC16A13, which encodes the monocarboxylate transporter 13 (MCT13), is a susceptibility gene for type 2 diabetes and is expressed in the liver and duodenum. Some peptidase-resistant oligopeptides are absorbed in the gastrointestinal tract and affect
Externí odkaz:
https://doaj.org/article/0a6f43494d824eaea8cca931839885f7
Publikováno v:
Journal of Pharmaceutical Health Care and Sciences, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract Background The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is the most frequent cause of hyponatremia in patients with cerebrovascular disease, and is often treated with oral salt tablets. However, we have shown that
Externí odkaz:
https://doaj.org/article/3460494e5b48410e96aded2d5a4e082d
Autor:
Hisanao Kishimoto, Kaori Miyazaki, Hiroshi Tedzuka, Ryosuke Ozawa, Hanai Kobayashi, Yoshiyuki Shirasaka, Katsuhisa Inoue
Publikováno v:
Molecules, Vol 26, Iss 21, p 6396 (2021)
As advanced synthetic technology has enabled drug candidate development with complex structure, resulting in low solubility and membrane permeability, the strategies to improve poorly absorbed drug bioavailability have attracted the attention of phar
Externí odkaz:
https://doaj.org/article/66cbc97d8737472fbb8f67ae55149a11
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 12, Iss 3 (2010)
Purpose. Human multidrug and toxin extrusion protein 1 (hMATE1) and hMATE2-K are organic cation/H+ antiporters that have recently been identified and suggested to be involved in the renal brush border secretion of various organic cations. Information
Externí odkaz:
https://doaj.org/article/ce82d1c4958c4cd19d135dc6a2944e4d
Autor:
Kaori Miyazaki, Hisanao Kishimoto, Hanai Kobayashi, Ayaka Suzuki, Kei Higuchi, Yoshiyuki Shirasaka, Katsuhisa Inoue
Publikováno v:
Molecular Pharmacology. 103:166-175
Publikováno v:
The AAPS Journal. 25
Autor:
Ryuto Tomabechi, Miki Miyasato, Taeka Sato, Tappei Takada, Kei Higuchi, Hisanao Kishimoto, Yoshiyuki Shirasaka, Katsuhisa Inoue
Publikováno v:
Molecular pharmaceutics. 20(1)
The therapeutic modalities that involve the endocytosis pathway, including antibody-drug conjugates (ADCs), have recently been developed. Since the drug escape from endosomes/lysosomes is a determinant of their efficacy, it is important to optimize t
Autor:
Katsuhisa Inoue, Tomoko Yamaguchi, Yoshiharu Deguchi, Kenji Kawabata, Tatsuki Mochizuki, Toshiki Kurosawa, Yuma Tega, Hiroyuki Kusuhara, Daiki Sako, Naoki Ito
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3484-3490
The likelihood of reoccurrence of acute lymphoblastic leukemia is influenced by the cerebral concentration of the therapeutic agent 6-mercaptopurine (6-MP) during treatment. Therefore, it is important to understand the blood-brain barrier (BBB) trans