Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Katsuhiro Togami"'
Autor:
Lucia Cabal-Hierro, Peter van Galen, Miguel A. Prado, Kelly J. Higby, Katsuhiro Togami, Cody T. Mowery, Joao A. Paulo, Yingtian Xie, Paloma Cejas, Takashi Furusawa, Michael Bustin, Henry W. Long, David B. Sykes, Steven P. Gygi, Daniel Finley, Bradley E. Bernstein, Andrew A. Lane
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Chromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification i
Externí odkaz:
https://doaj.org/article/f424d9b406fb49f7a429fe6474f60a2d
Autor:
Andrew A. Lane, H. Phillip Koeffler, Omar Abdel-Wahab, Francine Garnache-Ottou, Naveen Pemmaraju, Marina Konopleva, Henry Yang, Peter S. Hammerman, David M. Weinstock, Pier Paolo Piccaluga, Fabrice Jardin, Elizabeth A. Morgan, Abner Louissaint, Scott B. Lovitch, Silvia Buonamici, Michael Seiler, Sabeha Biichle, Fanny Angelot-Delettre, Yvonne Y. Li, Jia Li, Mahmoud Ghandi, Gabriel K. Griffin, Sunhee S. Kim, Justin Taylor, Lucia Cabal-Hierro, Christopher M. Kenyon, Christopher A.G. Booth, Vikas Madan, Sun Sook Chung, Katsuhiro Togami
Supplementary Figures S1-S8 with legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec467d08f4794ac5f85ded009f95a31
https://doi.org/10.1158/2159-8290.22541210.v1
https://doi.org/10.1158/2159-8290.22541210.v1
Autor:
Andrew A. Lane, H. Phillip Koeffler, Omar Abdel-Wahab, Francine Garnache-Ottou, Naveen Pemmaraju, Marina Konopleva, Henry Yang, Peter S. Hammerman, David M. Weinstock, Pier Paolo Piccaluga, Fabrice Jardin, Elizabeth A. Morgan, Abner Louissaint, Scott B. Lovitch, Silvia Buonamici, Michael Seiler, Sabeha Biichle, Fanny Angelot-Delettre, Yvonne Y. Li, Jia Li, Mahmoud Ghandi, Gabriel K. Griffin, Sunhee S. Kim, Justin Taylor, Lucia Cabal-Hierro, Christopher M. Kenyon, Christopher A.G. Booth, Vikas Madan, Sun Sook Chung, Katsuhiro Togami
Supplementary Tables 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4cf23850ead9d18cd22d06c66aecea
https://doi.org/10.1158/2159-8290.22541204
https://doi.org/10.1158/2159-8290.22541204
Autor:
Andrew A. Lane, H. Phillip Koeffler, Omar Abdel-Wahab, Francine Garnache-Ottou, Naveen Pemmaraju, Marina Konopleva, Henry Yang, Peter S. Hammerman, David M. Weinstock, Pier Paolo Piccaluga, Fabrice Jardin, Elizabeth A. Morgan, Abner Louissaint, Scott B. Lovitch, Silvia Buonamici, Michael Seiler, Sabeha Biichle, Fanny Angelot-Delettre, Yvonne Y. Li, Jia Li, Mahmoud Ghandi, Gabriel K. Griffin, Sunhee S. Kim, Justin Taylor, Lucia Cabal-Hierro, Christopher M. Kenyon, Christopher A.G. Booth, Vikas Madan, Sun Sook Chung, Katsuhiro Togami
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of plasmacytoid dendritic cells (pDC). BPDCN occurs at least three times more frequently in men than in women, but the reasons for this sex bias are unknown. Here, studyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d7f9d5d3f428fa805864e0d5204040
https://doi.org/10.1158/2159-8290.c.6549572
https://doi.org/10.1158/2159-8290.c.6549572
Autor:
Andrew A. Lane, H. Phillip Koeffler, Omar Abdel-Wahab, Francine Garnache-Ottou, Naveen Pemmaraju, Marina Konopleva, Henry Yang, Peter S. Hammerman, David M. Weinstock, Pier Paolo Piccaluga, Fabrice Jardin, Elizabeth A. Morgan, Abner Louissaint, Scott B. Lovitch, Silvia Buonamici, Michael Seiler, Sabeha Biichle, Fanny Angelot-Delettre, Yvonne Y. Li, Jia Li, Mahmoud Ghandi, Gabriel K. Griffin, Sunhee S. Kim, Justin Taylor, Lucia Cabal-Hierro, Christopher M. Kenyon, Christopher A.G. Booth, Vikas Madan, Sun Sook Chung, Katsuhiro Togami
DNA sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d61c9709474767dec1a2bb0d3c8eb0
https://doi.org/10.1158/2159-8290.22541207
https://doi.org/10.1158/2159-8290.22541207
Autor:
Andrew A. Lane, Anthony Letai, Naveen Pemmaraju, Marina Konopleva, Richard M. Stone, Nicole R. LeBoeuf, Matthew S. Davids, Jon C. Aster, Elizabeth A. Morgan, Ilene Galinsky, Leah J. Hogdal, Katsuhiro Togami, Lucia Cabal-Hierro, Gabriel K. Griffin, Tianyu Cai, Jason Stephansky, Joan Montero
Pathological analysis of human BPDCN growing as a patient-derived xenograft (PDX) in mice. Splenic tissue is shown stained with H&E (at 40x and 100x magnification), and human BCL-2, CD45, CD4, CD56, and CD123 (all at 40x) from animals bearing a repre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629b2195bd995bc6da7c18964377efc8
https://doi.org/10.1158/2159-8290.22531386.v1
https://doi.org/10.1158/2159-8290.22531386.v1
Autor:
Andrew A. Lane, Anthony Letai, Naveen Pemmaraju, Marina Konopleva, Richard M. Stone, Nicole R. LeBoeuf, Matthew S. Davids, Jon C. Aster, Elizabeth A. Morgan, Ilene Galinsky, Leah J. Hogdal, Katsuhiro Togami, Lucia Cabal-Hierro, Gabriel K. Griffin, Tianyu Cai, Jason Stephansky, Joan Montero
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157d9ea2ea4dd8290843e209e3ece1d1
https://doi.org/10.1158/2159-8290.22531377
https://doi.org/10.1158/2159-8290.22531377
Autor:
Andrew A. Lane, Anthony Letai, Naveen Pemmaraju, Marina Konopleva, Richard M. Stone, Nicole R. LeBoeuf, Matthew S. Davids, Jon C. Aster, Elizabeth A. Morgan, Ilene Galinsky, Leah J. Hogdal, Katsuhiro Togami, Lucia Cabal-Hierro, Gabriel K. Griffin, Tianyu Cai, Jason Stephansky, Joan Montero
Response of BPDCN and AML cells to navitoclax and A-1331852. (A) MTT assay results for the indicated cell lines after 72 hours of exposure to the indicated doses of navitoclax (combined BCL-2/BCL-XL inhibitor). (B) MTT assay results for the indicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e97576d3addcbb51384c4cb00f54c15
https://doi.org/10.1158/2159-8290.22531389.v1
https://doi.org/10.1158/2159-8290.22531389.v1
Autor:
Andrew A. Lane, Anthony Letai, Naveen Pemmaraju, Marina Konopleva, Richard M. Stone, Nicole R. LeBoeuf, Matthew S. Davids, Jon C. Aster, Elizabeth A. Morgan, Ilene Galinsky, Leah J. Hogdal, Katsuhiro Togami, Lucia Cabal-Hierro, Gabriel K. Griffin, Tianyu Cai, Jason Stephansky, Joan Montero
Time and dose-dependent response of primary BPDCN to venetoclax in vitro. (A) Cell death measurement by flow cytometry at 4 and 8 hours after addition of venetoclax at the indicated doses in a primary BPDCN, represented as change in Annexin V positiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e86f62d3fb0d0a26cab524abca31382
https://doi.org/10.1158/2159-8290.22531383.v1
https://doi.org/10.1158/2159-8290.22531383.v1
Autor:
Andrew A. Lane, Anthony Letai, Naveen Pemmaraju, Marina Konopleva, Richard M. Stone, Nicole R. LeBoeuf, Matthew S. Davids, Jon C. Aster, Elizabeth A. Morgan, Ilene Galinsky, Leah J. Hogdal, Katsuhiro Togami, Lucia Cabal-Hierro, Gabriel K. Griffin, Tianyu Cai, Jason Stephansky, Joan Montero
Venetoclax induces dose-dependent apoptotic cell death in BPDCN and AML cell lines. (A) Representative Annexin V-FITC vs propidium iodide (PI) flow cytometry staining to measure apoptosis induction in CAL1 cells after 24 hours of exposure to vehicle,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a03c4981e8f655a9470696f809aaea5
https://doi.org/10.1158/2159-8290.22531392.v1
https://doi.org/10.1158/2159-8290.22531392.v1