Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Katsuhiro Mihara"'
Autor:
Kyoko Miyamoto, Robert M. Miller, Christine Voors‐Pette, Jart A. F. Oosterhaven, Marieke van denDobbelsteen, Katsuhiro Mihara, Marian Geldof, Yuji Sato, Naomi Matsuda, Shirou Kirita, Masaaki Sawa, Akinori Arimura
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 11, Pp n/a-n/a (2024)
Abstract Bruton's tyrosine kinase (BTK) is a potential therapeutic target for allergic and autoimmune diseases. This first‐in‐human phase I study evaluated safety, pharmacokinetic, and pharmacodynamic profiles of sofnobrutinib (formerly AS‐0871
Externí odkaz:
https://doaj.org/article/cbb99c7b7d034244b1d76a7bb8338933
Autor:
Akinori Arimura, Kyoko Miyamoto, Maria Velinova, Marieke van den Dobbelsteen, Katsuhiro Mihara, Robert M. Miller, Masaaki Sawa
Publikováno v:
Cancer Research. 82:CT137-CT137
Background: Covalent Bruton’s tyrosine kinase (BTK) inhibitors such as ibrutinib are approved for treating patients with B-cell malignancies, but their long-term efficacy is limited due to their toxicity (i.e., on-target and off-target inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b507bbe93fa53c0f541f0fe7f69a0b82
https://doi.org/10.1158/1538-7445.am2022-ct137
https://doi.org/10.1158/1538-7445.am2022-ct137
Autor:
Patrick Aubonnet, Jean-Claude Ansquer, Katsuhiro Mihara, Dirk Lehnick, Anneke Winsemius, Stefan Driessen, Hanneke van Assche, Katrin Beckmann, Peter van Amsterdam, Gabi Piskol, Matthias Olbrich
Publikováno v:
The Journal of Clinical Pharmacology. 54:1038-1047
Simvastatin and fenofibrate are frequently co-prescribed at staggered intervals for the treatment of dyslipidemia. Since a drug-drug interaction has been reported when the two drugs are given simultaneously, it is of clinical interest to know whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f9231c884cbb947376046a14651c8d9
https://doi.org/10.1002/jcph.291
https://doi.org/10.1002/jcph.291
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 46(10)
1. The metabolism of dydrogesterone was investigated in human liver cytosol (HLC) and human liver microsomes (HLM). Enzymes involved in dydrogesterone metabolism were identified and their relative contributions were estimated. 2. Dydrogesterone clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9cbbab47602a198480a66bfeadfc72
https://pubmed.ncbi.nlm.nih.gov/26796435
https://pubmed.ncbi.nlm.nih.gov/26796435
Autor:
Anneke, Winsemius, Jean-Claude, Ansquer, Matthias, Olbrich, Peter, van Amsterdam, Patrick, Aubonnet, Katrin, Beckmann, Stefan, Driessen, Hanneke, van Assche, Gabi, Piskol, Dirk, Lehnick, Katsuhiro, Mihara
Publikováno v:
Journal of clinical pharmacology. 54(9)
Simvastatin and fenofibrate are frequently co-prescribed at staggered intervals for the treatment of dyslipidemia. Since a drug-drug interaction has been reported when the two drugs are given simultaneously, it is of clinical interest to know whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65bdf7bb50fc03879ba3f0202077d9fa
https://pubmed.ncbi.nlm.nih.gov/24691799
https://pubmed.ncbi.nlm.nih.gov/24691799
Publikováno v:
Chemokine Receptors as Drug Targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0ec9e7a058a045709e8ac4d4da8591a
https://doi.org/10.1002/9783527631995.ch12
https://doi.org/10.1002/9783527631995.ch12
Autor:
Katsuhiro Mihara, Jay S. Fine, Ying Li, David Kinsley, Laura W. Engstrom, Rob Nelissen, M. Consuelo Pinzon-Ortiz, Shu-Cheng Chen, Denise Manfra
Publikováno v:
International immunopharmacology. 9(10)
Molecular and cellular assessment of dermal delayed-type hypersensitivity (DTH) responses is a useful approach for evaluating the mechanism of action (MOA) of immunomodulatory agents. In the present report, we characterized the delayed-type hypersens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3218ec1f5d77578bf585c4cead20d583
https://pubmed.ncbi.nlm.nih.gov/19616132
https://pubmed.ncbi.nlm.nih.gov/19616132
Publikováno v:
Biologicalpharmaceutical bulletin. 30(7)
The CXC chemokine receptor CXCR2 has been implicated in the pathogenesis of several chronic diseases including atherosclerosis. To enable animal studies towards understanding the role of human CXCR2 (hCXCR2) in disease development, we previously gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675532304efd3b0c966328d2650afe4f
https://pubmed.ncbi.nlm.nih.gov/17603159
https://pubmed.ncbi.nlm.nih.gov/17603159
Autor:
Magda A. M. Krajnc-Franken, Katsuhiro Mihara, Wim Dokter, Jan A. Gossen, Martin-Jan Smit, Martijn Rooseboom
Publikováno v:
European journal of immunology. 35(9)
Human CXCR2 (hCXCR2) has been implicated in diverse inflammatory diseases. When roles of this receptor studied in animal models are extrapolated into men, large species differences in expression of the receptor and its ligands must be considered. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d06edecc7efb451a24c4e4cc48ca93
https://pubmed.ncbi.nlm.nih.gov/16094689
https://pubmed.ncbi.nlm.nih.gov/16094689