Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Katsuhiro Kanda"'
Autor:
Katsuhiro Kanda
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S53-S54
Publikováno v:
Drug metabolism and pharmacokinetics. 33(3)
This study describes the total disposition profiling of rosuvastatin (RSV) and pitavastatin (PTV) using a single systematic procedure called D-PREX (Disposition Profile Exploration) in sandwich-cultured human hepatocytes (SCHH). The biliary excretion
Autor:
Kazuo Takayama, Hiroyuki Mizuguchi, Takao Hayakawa, Masashi Tachibana, Miho Furue, Fuminori Sakurai, Katsuhiro Kanda, Katsuhisa Tashiro, Keisuke Kishimoto, Kenji Kawabata, Yasuhito Nagamoto
Publikováno v:
Biomaterials. 34:1781-1789
Although it is expected that hepatocyte-like cells differentiated from human embryonic stem (ES) cells or induced pluripotent stem (iPS) cells will be utilized in drug toxicity testing, the actual applicability of hepatocyte-like cells in this contex
Autor:
Kazumi Suzuki, Katsuhiro Kanda, Shizuko Ishii, Shin-ichiro Ejiri, Toshitsugu Sato, Hitoshi Enei
Publikováno v:
Bioscience, biotechnology, and biochemistry. 60(3)
A correlation between tyrosinase activity and gill browning during preservation of Lentinus edodes fruit-bodies was observed. Latent-type tyrosinase was recognized in the precipitate of the gill homogenate, and activation of the tyrosinase was brough
Autor:
Masaru Mori, Marina Nozawa, Junichi Goto, Nariyasu Mano, Miki Shimada, Katsuhiro Kanda, Hiroaki Yamaguchi, Mayumi Sato, Makoto Nogami
Publikováno v:
Journal of Chromatography B. 879:968-974
Ion suppression can negatively affect the performance characteristics of LC/ESI-MS/MS based methods, and we wished to identify sources of ion suppression in an assay for quantitating sirolimus in human whole blood. We first compared the peak areas of
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S68
Autor:
Yukie Sasakura, Rumiko Inada, Tsuyoshi Ogino, Makoto Nogami, Katsuhiro Kanda, Masaki Watanabe
Publikováno v:
Bulletin of the Chemical Society of Japan. 81:636-640
For mass spectroscopy (MS)-based protein structural analyses, effective digestion by proteases is one of the key steps. In this study, we developed a protein digestion method using immobilized enzy...
Autor:
Katsuhiro Kanda
Publikováno v:
SEIBUTSU BUTSURI KAGAKU. 51:37-44
Mass spectrometer is one of the most promising instruments for proteomics and metabolomics. It is not only applied for the protein and small molecule identification, but also for the complicated post-translational modification analysis, biomarker dis
Publikováno v:
Analytica Chimica Acta. 564:53-58
Protein microarray technology is a powerful, popular tool for the high-throughput analysis of protein interactions. One important use for protein microarray technology is protein quantification by immunoassay, which was originally based on enzyme lin
Autor:
Takuya Matsui, Katsuhiro Kanda, Tokiko Yoshimura-Suzuki, Moon Hi Han, Yukie Sasakura, Toru Shimizu, Shinichi Fukuzono
Publikováno v:
Analytical Chemistry. 76:6521-6527
A highly sensitive microarray system for detecting protein-protein interactions has been developed. This method was successfully applied to analyze the interactions of heme-regulated phosphodiesterase from Escherichia coli (Ec DOS). To immobilize (Hi