Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Katsuhiro Imaki"'
Autor:
Masanori Kawamura, Yoshisuke Nakayama, Okada Takanori, Katsuhiro Imaki, Takaaki Amino, Yasuhiro Sakai, Kaoru Kobayashi, Tetsuya Mohri, Hisao Nakai, Yuuki Nagao
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:2115-2134
A novel series of pivaloyloxy benzene derivatives has been identified as potent and selective human neutrophil elastase (HNE) inhibitors. Convergent syntheses were developed in order to identify the inhibitors which are intravenously effective in an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0134614e78e51916a0b73a447fe37018
https://doi.org/10.1016/s0968-0896(96)00216-7
https://doi.org/10.1016/s0968-0896(96)00216-7
Autor:
Mitoshi Konno, Katsuhiro Imaki, Takahiko Nakae, Nobuyuki Hamanaka, Sakuyama Shigeru, Hisao Nakai
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ba178790b2c16ea67a304f5e47fec62
https://doi.org/10.1002/chin.199814085
https://doi.org/10.1002/chin.199814085
Autor:
Sakuyama Shigeru, Mitoshi Konno, Takahiko Nakae, Katsuhiro Imaki, Nobuyuki Hamanaka, Hisao Nakai
Publikováno v:
Synlett. 12:1472-1474
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a94fae50ced3f13f358fb5c51ad1dc80
https://doi.org/10.1055/s-1997-1079
https://doi.org/10.1055/s-1997-1079
Autor:
Katsuhiro Imaki, Kazuhito Kawabata, Mayumi Suzuki, Masafumi Sugitani, Tsumoru Miyamoto, Masaaki Toda
Publikováno v:
Biochemical and Biophysical Research Communications. 177:814-820
ONO-5046, N-[2-[4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino] aminoacetic acid, competitively inhibited human neutrophil elastase (IC50 = 0.044 microM, Ki = 0.2 microM). It also inhibited leukocyte elastase obtained from rabbit, rat, hamster and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445e995f0ce34a5a98b498867af0dcd5
https://doi.org/10.1016/0006-291x(91)91862-7
https://doi.org/10.1016/0006-291x(91)91862-7
Publikováno v:
Chemical and Pharmaceutical Bulletin. 29:2699-2701
Pyroglutamic acid reacted with acyl chloride in the presence of triethylamine in acetonitrile, yielding N-acylpyroglutamic acid without epimerization by way of mixed anhydride formation followed by intramolecular N-acylation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c3c69a8d058420db0e3084fff6c0e00
https://doi.org/10.1248/cpb.29.2699
https://doi.org/10.1248/cpb.29.2699
Autor:
Tsumoru Miyamoto, Okegawa T, Okada Takanori, Katsuhiro Imaki, Masaaki Toda, Sakuyama Shigeru, Masaki Hayashi, Akiyoshi Kawasaki
Publikováno v:
Chemicalpharmaceutical bulletin. 29(8)
1-[3-Mercaptoalkanoyl] pyroglutamic acids and 1-[3-mercaptoalkanoyl]-4-hetero (oxa, thia and aza) pyroglutamic acids were prepared and their inhibitory activities against angiotensin-converting enzyme (ACE) were examined. (2S)-1-[(2S)-3-Mercapto-2-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fb492247b61328efa5f96264e416e3
https://pubmed.ncbi.nlm.nih.gov/6274523
https://pubmed.ncbi.nlm.nih.gov/6274523
Autor:
Syozo Matsuoka, Mayumi Futagami, Hiroyuki Ohno, Katsuhiro Imaki, Tadao Okegawa, Akiyoshi Kawasaki
Publikováno v:
Japanese journal of pharmacology. 51(4)
The effect of ONO-3307 (4-sulfamoyl phenyl-4-guanidinobenzoate methanesulfonate), a new protease inhibitor, was studied on various proteases in vitro and in an experimental thrombosis model in vivo. ONO-3307 competitively inhibited trypsin, thrombin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42910963f4f975b10e59b0eca5024db2
https://pubmed.ncbi.nlm.nih.gov/2515329
https://pubmed.ncbi.nlm.nih.gov/2515329
Publikováno v:
Prostaglandins. 10(4)
Radioimmunoassay of 5alpha, 7alpha-dihydroxy-11-keto-tetranorprosta-1,16-dioic acid, main urinary metabolite of prostaglandin F2alpha (PGF2alpha), was performed using an antiserum produced in the rabbit. The antibody in 100 mu1 of 1,600-fold diluted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b25f055b6bbc775062e60f93bd8665
https://pubmed.ncbi.nlm.nih.gov/812153
https://pubmed.ncbi.nlm.nih.gov/812153
Publikováno v:
Prostaglandins. 6(2)
Radioimmunoassays for measuring prostaglandin F 2α (PGF 2α ) and 5α, 7α-dihydroxy-11-keto tetranorprosta-1,16-dioic acid, PGF 2α -main urinary metabolite (PGF 2α -MUM), with 125 I-tyrosine methylester amide (TMA) of PGF 2α and PGF 2α -MUM wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6c4c6b44e03e57729566d151727058
https://pubmed.ncbi.nlm.nih.gov/4858806
https://pubmed.ncbi.nlm.nih.gov/4858806
Autor:
Masaki Hayashi, Katsuhiro Imaki, Akiyoshi Kawasaki, Okegawa T, Sakuyama Shigeru, Masaaki Toda, Okada Takanori, Tsumoru Miyamoto
Publikováno v:
Chemischer Informationsdienst. 13
1-[3-Mercaptoalkanoyl] pyroglutamic acids and 1-[3-mercaptoalkanoyl]-4-hetero (oxa, thia and aza) pyroglutamic acids were prepared and their inhibitory activities against angiotensin-converting enzyme (ACE) were examined. (2S)-1-[(2S)-3-Mercapto-2-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b8c32db05217d350e9452bb4c221652
https://doi.org/10.1002/chin.198203158
https://doi.org/10.1002/chin.198203158