Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Katsuhiko Nosho"'
Autor:
Tomotaka Ugai, Melissa Zhao, Takashi Shimizu, Naohiko Akimoto, Shanshan Shi, Yasutoshi Takashima, Rong Zhong, Mai Chan Lau, Koichiro Haruki, Kota Arima, Kenji Fujiyoshi, Benjamin Langworthy, Yohei Masugi, Annacarolina da Silva, Katsuhiko Nosho, Yoshifumi Baba, Mingyang Song, Andrew T. Chan, Molin Wang, Jeffrey A. Meyerhardt, Marios Giannakis, Juha P. Väyrynen, Jonathan A. Nowak, Shuji Ogino
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Immunotherapy targeting the CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint axis has emerged as a promising treatment strategy for various cancers. Experimental evidence suggests that phosphatidylinositol-4,5-bisphosphonate 3-kinase (PI3K) signaling may
Externí odkaz:
https://doaj.org/article/8315443e3399426abca4162e65e060a8
Autor:
Marios Giannakis, Xinmeng Jasmine Mu, Sachet A. Shukla, Zhi Rong Qian, Ofir Cohen, Reiko Nishihara, Samira Bahl, Yin Cao, Ali Amin-Mansour, Mai Yamauchi, Yasutaka Sukawa, Chip Stewart, Mara Rosenberg, Kosuke Mima, Kentaro Inamura, Katsuhiko Nosho, Jonathan A. Nowak, Michael S. Lawrence, Edward L. Giovannucci, Andrew T. Chan, Kimmie Ng, Jeffrey A. Meyerhardt, Eliezer M. Van Allen, Gad Getz, Stacey B. Gabriel, Eric S. Lander, Catherine J. Wu, Charles S. Fuchs, Shuji Ogino, Levi A. Garraway
Publikováno v:
Cell Reports, Vol 15, Iss 4, Pp 857-865 (2016)
Large-scale genomic characterization of tumors from prospective cohort studies may yield new insights into cancer pathogenesis. We performed whole-exome sequencing of 619 incident colorectal cancers (CRCs) and integrated the results with tumor immuni
Externí odkaz:
https://doaj.org/article/850e0199796a43f3a0af3cf012e732a1
Autor:
Tsuyoshi Hamada, Thing Rinda Soong, Yohei Masugi, Keisuke Kosumi, Jonathan A. Nowak, Annacarolina da Silva, Xinmeng Jasmine Mu, Tyler S. Twombly, Hideo Koh, Juhong Yang, Mingyang Song, Li Liu, Mancang Gu, Yan Shi, Katsuhiko Nosho, Teppei Morikawa, Kentaro Inamura, Sachet A. Shukla, Catherine J. Wu, Levi A. Garraway, Xuehong Zhang, Kana Wu, Jeffrey A. Meyerhardt, Andrew T. Chan, Jonathan N. Glickman, Scott J. Rodig, Gordon J. Freeman, Charles S. Fuchs, Reiko Nishihara, Marios Giannakis, Shuji Ogino
Publikováno v:
OncoImmunology, Vol 7, Iss 7 (2018)
Inhibitors targeting the PDCD1 (programmed cell death 1, PD-1) immune checkpoint pathway have revolutionized cancer treatment strategies. The TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PDCD1 ligand 1, PD-L1) ex
Externí odkaz:
https://doaj.org/article/63ee06ae114e4a4fba2cde1620b7523b
Autor:
Tomoya Iida, Yosuke Ohkubo, Toshiyuki Kubo, Kentaro Yamashita, Kei Onodera, Eiichiro Yamamoto, Katsuhiko Nosho, Toshiro Ito, Hiroo Yamano, Hiroshi Nakase
Publikováno v:
Endoscopy International Open, Vol 06, Iss 02, Pp E186-E189 (2018)
Background and study aims Ischemic proctitis is a rare disease and comprises 2 % to 5 % of cases of ischemic colitis, because the rectum has abundant blood supply and rich collaterals. Herein, we report a case of a 73-year-old male patient with a pro
Externí odkaz:
https://doaj.org/article/b3956ecedfeb4468985d88a99ae4b9c4
Autor:
Keisuke Kosumi, Yohei Masugi, Juhong Yang, Zhi Rong Qian, Sun A. Kim, Wanwan Li, Yan Shi, Annacarolina da Silva, Tsuyoshi Hamada, Li Liu, Mancang Gu, Tyler S. Twombly, Yin Cao, David A. Barbie, Katsuhiko Nosho, Hideo Baba, Wendy S. Garrett, Jeffery A. Meyerhardt, Edward L. Giovannucci, Andrew T. Chan, Charles S. Fuchs, Shuji Ogino, Reiko Nishihara
Publikováno v:
OncoImmunology, Vol 6, Iss 3 (2017)
Evidence suggests that activation of autophagy in neoplastic cells potentiates antitumor immunity through cross-presentation of tumor-associated antigens to T cells and release of immune mediators. The SQSTM1 (sequestosome 1, p62) protein is degraded
Externí odkaz:
https://doaj.org/article/62cb664b0a264a0c98bb39f0f55b897d
Autor:
Yoshifumi Baba, Katsuhiko Nosho, Kaori Shima, Natsumi Irahara, Shoko Kure, Saori Toyoda, Gregory J. Kirkner, Ajay Goel, Charles S. Fuchs, Shuji Ogino
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 5, Pp 418-425 (2009)
AURKA (the official symbol for Aurora-A, STK15, or BTAK) regulates the function of centrosomes, spindles, and kinetochores for proper mitotic progression. AURKA overexpression is observed in various cancers including colon cancer, and a link between
Externí odkaz:
https://doaj.org/article/9b8dae3aae1a46d9ba7386534d665c28
Autor:
Katsuhiko Nosho, Kaori Shima, Shoko Kure, Natsumi Irahara, Yoshifumi Baba, Li Chen, Gregory J. Kirkner, Charles S. Fuchs, Shuji Ogino
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 1, Pp 87-95 (2009)
JC virus has a transforming gene encoding JC virus T-antigen (JCVT). JCVT may inactivate wild-type p53, cause chromosomal instability (CIN), and stabilize β-catenin. A link between JCVT and CpG island methylator phenotype (CIMP) has been suggested.
Externí odkaz:
https://doaj.org/article/1a79ce1524844c7fa133be6f64c3502a
Autor:
Katsuhiko Nosho, Takako Kawasaki, Janina A. Longtine, Charles S. Fuchs, Mutsuko Ohnishi, Yuko Suemoto, Gregory J. Kirkner, Dimity Zepf, Liying Yan, Shuji Ogino
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 6, Pp 534-541 (2008)
Somatic PIK3CA mutations are often present in colorectal cancer. Mutant PIK3CA activates AKT signaling, which up-regulates fatty acid synthase (FASN). Microsatellite instability (MSI) and CpG island methylator phenotype (CIMP) are important molecular
Externí odkaz:
https://doaj.org/article/5c1ca9b15aac496eac53556ad09e7fea
Autor:
Takako Kawasaki, Katsuhiko Nosho, Mutsuko Ohnishi, Yuko Suemoto, Gregory J. Kirkner, Charles S. Fuchs, Shuji Ogino
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 12, Pp 1091-1098 (2007)
Insulin-like growth factor binding protein 3 (IGFBP3), which is induced by wild-type p53, regulates IGF and interacts with the TGF-β pathway. IGFBP3 promoter methylation may occur in colorectal cancer with or without the CpG island methylator phenot
Externí odkaz:
https://doaj.org/article/09379761a7fa40a585098add2928088c
Autor:
Takako Kawasaki, Katsuhiko Nosho, Mutsuko Ohnishi, Yuko Suemoto, Gregory J. Kirkner, Reiko Dehari, Jeffrey A. Meyerhardt, Charles S. Fuchs, Shuji Ogino
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 7, Pp 569-577 (2007)
The WNT/β-catenin (CTNNB1) pathway is commonly activated in the carcinogenic process. Cross-talks between the WNT and cyclooxygenase-2 (COX-2 or PTGS2)/prostaglandin pathways have been suggested. The relationship between (3-catenin activation and mi
Externí odkaz:
https://doaj.org/article/9a9c7dc3b70e45f286a4c8148488d087