Zobrazeno 1 - 10
of 1 019
pro vyhledávání: '"Katsuhiko Mikoshiba"'
Autor:
Songbai Zhang, Ayako Miyakawa, Malin Wickström, Cecilia Dyberg, Lauri Louhivuori, Manuel Varas-Godoy, Kati Kemppainen, Shigeaki Kanatani, Dagmara Kaczynska, Ivar Dehnisch Ellström, Lotta Elfman, Pauliina Kronqvist, Heli Repo, Katsuhiko Mikoshiba, Cecilia Sahlgren, John Inge Johnsen, Per Uhlén
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Notch signalling is reported to be hyperactivated in oestrogen receptor-negative (ER-) breast cancer. Here the authors show that G protein-coupled receptor kinase-interacting protein 1 (GIT1) negatively regulates Notch signalling and tumour growth in
Externí odkaz:
https://doaj.org/article/bcf68ef5145e4a00816fadb87092743a
Autor:
Ming Zhang, Jian Wang, Kaixiang Zhang, Guozhen Lu, Yuming Liu, Keke Ren, Wenting Wang, Dazhuan Xin, Lingli Xu, Honghui Mao, Junlin Xing, Xingchun Gao, Weilin Jin, Kalen Berry, Katsuhiko Mikoshiba, Shengxi Wu, Q. Richard Lu, Xianghui Zhao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelination during development and remyelinati
Externí odkaz:
https://doaj.org/article/e1cbd11d253c49be9a1549ae252b0873
Autor:
Ryo Itoh, Naoya Hatano, Momoko Murakami, Kosuke Mitsumori, Satoko Kawasaki, Tomoka Wakagi, Yoshino Kanzaki, Hiroyuki Kojima, Katsuhiro Kawaai, Katsuhiko Mikoshiba, Koichi Hamada, Akihiro Mizutani
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Anion exchanger 2 (AE2) plays crucial roles in regulating cell volume homeostasis and cell migration. We found that both IRBIT and Long-IRBIT (L-IRBIT) interact with anion exchanger 2 (AE2). The interaction occurred between the conserved AHC
Externí odkaz:
https://doaj.org/article/d559a802affd44caa044cb922f75ff21
Autor:
Misa Arizono, V. V. G. Krishna Inavalli, Aude Panatier, Thomas Pfeiffer, Julie Angibaud, Florian Levet, Mirelle J. T. Ter Veer, Jillian Stobart, Luigi Bellocchio, Katsuhiko Mikoshiba, Giovanni Marsicano, Bruno Weber, Stéphane H. R. Oliet, U. Valentin Nägerl
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Astrocytic Ca2+ signals can be fast and local, supporting the idea that astrocytes have the ability to regulate single synapses. Here, the authors report the organization of astrocytes at nanoscale level and identify nodes as a functional astrocytic
Externí odkaz:
https://doaj.org/article/3536e6c7c87e43ed8b8fc2be5602d472
Autor:
Hiroyuki Kabayama, Makoto Takeuchi, Naoko Tokushige, Shin-ichi Muramatsu, Miyuki Kabayama, Mitsunori Fukuda, Yoshiyuki Yamada, Katsuhiko Mikoshiba
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Antibodies expressed in the cytosol often form insoluble aggregates, which makes it hard to target intracellular proteins. Here the authors engineer an ultra-stable cytoplasmic antibody (STAND) with a low isoelectric point that can be used in vivo.
Externí odkaz:
https://doaj.org/article/f9143607edfe4e95b8e2df11ca430e7f
Autor:
Takashi Sugiyama, Naoya Murao, Hisae Kadowaki, Keizo Takao, Tsuyoshi Miyakawa, Yosuke Matsushita, Toyomasa Katagiri, Akira Futatsugi, Yohei Shinmyo, Hiroshi Kawasaki, Juro Sakai, Kazutaka Shiomi, Masamitsu Nakazato, Kohsuke Takeda, Katsuhiko Mikoshiba, Hidde L. Ploegh, Hidenori Ichijo, Hideki Nishitoh
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102758- (2021)
Summary: Derlin family members (Derlins) are primarily known as components of the endoplasmic reticulum-associated degradation pathway that eliminates misfolded proteins. Here we report a function of Derlins in the brain development. Deletion of Derl
Externí odkaz:
https://doaj.org/article/b69667e8cdc0451bb9c8130fc2b00445
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Astrocytes are sensitive to ongoing neuronal/network activities and, accordingly, regulate neuronal functions (synaptic transmission, synaptic plasticity, behavior, etc.) by the context-dependent release of several gliotransmitters (e.g., glutamate,
Externí odkaz:
https://doaj.org/article/d415ce92974d423bbfe73c0cd52b3b9f
Autor:
Fumikazu Sano, Eiji Shigetomi, Youichi Shinozaki, Haruka Tsuzukiyama, Kozo Saito, Katsuhiko Mikoshiba, Hiroshi Horiuchi, Dennis Lawrence Cheung, Junichi Nabekura, Kanji Sugita, Masao Aihara, Schuichi Koizumi
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Extensive activation of glial cells during a latent period has been well documented in various animal models of epilepsy. However, it remains unclear whether activated glial cells contribute to epileptogenesis, i.e., the chronically persistent proces
Externí odkaz:
https://doaj.org/article/a915495c6e1f433aba8681799e7b07bc
Autor:
Adam Bartok, David Weaver, Tünde Golenár, Zuzana Nichtova, Máté Katona, Száva Bánsághi, Kamil J. Alzayady, V. Kaye Thomas, Hideaki Ando, Katsuhiko Mikoshiba, Suresh K. Joseph, David I. Yule, György Csordás, György Hajnóczky
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Membrane contact sites between the ER and mitochondria are known to convey calcium signals between these two organelles via IP3 receptors, but the molecular mechanisms are currently unclear. Here, the authors show that IP3 receptors play a structural
Externí odkaz:
https://doaj.org/article/573c9a6e3c934f97817996bbe29c011b
Autor:
Carmen Chan, Noriko Ooashi, Hiroki Akiyama, Tetsuko Fukuda, Mariko Inoue, Toru Matsu-ura, Tomomi Shimogori, Katsuhiko Mikoshiba, Hiroyuki Kamiguchi
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: During neurodevelopment, the growth cone deciphers directional information from extracellular guidance cues presented as shallow concentration gradients via signal amplification. However, it remains unclear how the growth cone controls this
Externí odkaz:
https://doaj.org/article/283c162fe54a4adfa9dcd629eec28cfc