Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Katsuhiko Gato"'
Autor:
Nasa Sakamoto, Katsuhiko Gato
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 79, Iss 10, Pp 920-922 (2023)
Quabodepistat [(5-{[(3R,4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidin-4-yl]methoxy}-8-fluoro-3,4-dihydroquinolin-2(1H)-one); C21H20ClF3N2O4] and 2,5-dihydroxybenzoic acid (2,5DHBA; C7H6O4) were successfully co-crystallized. Given the sma
Externí odkaz:
https://doaj.org/article/3048a425765a46c5b8a25ee11de7ba09
Autor:
Naoya Tsuno, Varin Titapiwatanakun, Kazuhiko Takatori, Toshiro Fukami, Nasa Sakamoto, Katsuhiko Gato, Ryotaro Koyama
Publikováno v:
Chemical and Pharmaceutical Bulletin. 69:995-1004
Cocrystal engineering can alter the physicochemical properties of a drug and generate a superior drug candidate for formulation design. Oxyresveratrol (ORV) exhibits a poor solubility in aqueous environments, thereby resulting in a poor bioavailabili
Autor:
Mika Yoshimura-Fujii, Ryogo Shikaku, Tatsuo Koide, Suguru Kato, Katsuhiko Gato, Toshiro Fukami
Publikováno v:
YAKUGAKU ZASSHI. 140:1175-1183
The mock patches were prepared with novel acrylic polymers as adhesive layer where biphenyl-4-ylacetic acid (BAA) or 2-(2-fluorobiphenyl-4-yl) propanoic acid (FPA) was used as model active pharmaceutical ingredients (APIs). In addition, the mock patc
Autor:
Hiroshi Hisada, Tatsuo Koide, Mika Yoshimura Fujii, Katsuhiko Gato, James Carriere, Toshiro Fukami
Publikováno v:
Journal of Drug Delivery Science and Technology. 58:101800
In this study, we prepared mock patches consisting of model drug (felbinac) and three types of acrylic polymers with different functional substituent and/or physical properties, and evaluated the correlation of pharmaceutical properties and molecular
Autor:
Toshiro Fukami, Yosuke Ozawa, Tatsuo Koide, Motoki Inoue, Katsuhiko Gato, Mika Yoshimura Fujii, Hiroshi Hisada
Publikováno v:
European Journal of Lipid Science and Technology. 122:1900171
Autor:
Eiji Kurosaki, Masanao Sanagi, Hiroyuki Okumura, Hiroaki Masuzaki, Katsuhiko Gato, Kazuya Honbou, Akira Suwa, Takako Yonemoto, Tomohiko Yamaguchi, Yuko Kawasaki, Yuichi Tomura, Hirotoshi Kakuta, Tatsuya Niimi, Masaya Orita
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 349:10-20
A proportion of angiotensin II type 1 receptor blockers (ARBs) improves glucose dyshomeostasis and insulin resistance in a clinical setting. Of these ARBs, telmisartan has the unique property of being a partial agonist for peroxisome proliferator-act
Autor:
Katsuhiko Gato, Keitaro Kadono, Shigeyuki Terashita, Toshio Teramura, Takafumi Akabane, Kenji Tabata
Publikováno v:
Drug Metabolism and Disposition. 38:1230-1237
This study aimed to establish a practical and convenient method of predicting intestinal availability (F(g)) in humans for highly permeable compounds at the drug discovery stage, with a focus on CYP3A4-mediated metabolism. We constructed a "simplifie
Publikováno v:
Chemical and Pharmaceutical Bulletin. 44:2142-2149
Altohyrtins A (1), B (2), and C (3) and 5-desacetylaltohyrtin A (4), extremely potent cytotoxic macrolides, have been isolated from the Okinawan marine sponge Hyrtios altum. The absolute stereostructures of these macrolides have been elucidated on th
Autor:
Isao Kitagawa, Katsuyoshi Matsunami, Katsuhiko Gato, S. Aoki, Motomasa Kobayashi, Michio Kurosu
Publikováno v:
ChemInform. 26
Publikováno v:
ChemInform. 28