Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Katsuaki Hoshino"'
Autor:
Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta, Hiroaki Hemmi, Takashi Kato, Asumi Yamamoto, Emi Tosuji, Shin-Ichiroh Saitoh, Takashi Tanaka, Katsuaki Hoshino, Shinji Fukuda, Kensuke Miyake, Etsushi Kuroda, Ken J. Ishii, Takao Iwawaki, Koichi Furukawa, Tsuneyasu Kaisho
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113981- (2024)
Summary: Cholera toxin (CT), a bacterial exotoxin composed of one A subunit (CTA) and five B subunits (CTB), functions as an immune adjuvant. CTB can induce production of interleukin-1β (IL-1β), a proinflammatory cytokine, in synergy with a lipopol
Externí odkaz:
https://doaj.org/article/f22ab996a6a3412b82cc9ee0414c17dd
Autor:
Shu Horiuchi, Takuya Koike, Hirofumi Takebuchi, Katsuaki Hoshino, Izumi Sasaki, Yuri Fukuda-Ohta, Tsuneyasu Kaisho, Daisuke Kitamura
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Generation of memory B cells is one of the key features of adaptive immunity as they respond rapidly to re-exposure to the antigen and generate functional antibodies. Although the functions of memory B cells are becoming clearer, the regulation of me
Externí odkaz:
https://doaj.org/article/b6035da134f149289bcc8ae857600063
Autor:
Toshiro Niki, Koji Fujita, Hugo Rosen, Mitsuomi Hirashima, Tsutomu Masaki, Toshio Hattori, Katsuaki Hoshino
Publikováno v:
Cellular Physiology and Biochemistry, Vol 50, Iss 5, Pp 1856-1868 (2018)
Background/Aims: Galectin-9 is a soluble immune modulator with versatile functions, including a role as an immune checkpoint molecule. Therefore, the amount of galectin-9 in the blood may reflect an individual’s immunological balance. Many studies
Externí odkaz:
https://doaj.org/article/88ccacaf700a4665ae0a0f99f66fc4b5
Autor:
Ting Liu, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Koichi Shikada, Mai Yamagishi, Katsuaki Hoshino, Tsuneyasu Kaisho, Kiwamu Takemoto, Toshihiko Suzuki, Erina Kuranaga, Osamu Ohara, Masayuki Miura
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 974-982 (2014)
Inflammasome-mediated caspase-1 activation is involved in cell death and the secretion of the proinflammatory cytokine interleukin-1β (IL-1β). Although the dynamics of caspase-1 activation, IL-1β secretion, and cell death have been examined with b
Externí odkaz:
https://doaj.org/article/cca359d232154dd1ada665776236e554
Publikováno v:
Biochemical and Biophysical Research Communications. 627:130-136
D-Allose is classified as a 'rare sugar,' i.e., part of the group of monosaccharides that are present in low quantities in the natural world. D-Allose has been demonstrated to exert many physiological functions. The effects of the rare sugars on immu
Autor:
Ryota Sato, Kaiwen Liu, Takuma Shibata, Katsuaki Hoshino, Kiyoshi Yamaguchi, Toru Miyazaki, Ryosuke Hiranuma, Ryutaro Fukui, Yuji Motoi, Yuri Fukuda-Ohta, Yun Zhang, Tatjana Reuter, Yuko Ishida, Toshikazu Kondo, Tomoki Chiba, Hiroshi Asahara, Masato Taoka, Yoshio Yamauchi, Toshiaki Isobe, Tsuneyasu Kaisho, Yoichi Furukawa, Eicke Latz, Kensuke Miyake
Hepatic macrophages maintain liver homeostasis, but little is known about the signals that activate the hepatoprotective programs within macrophages. Here, we show that toll-like receptor 13 (TLR13), a sensor of bacterial 23S ribosomal RNA (rRNA), se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c23e1b925cdc039b5eb914a5ae4ff8ce
https://doi.org/10.1101/2023.05.11.540294
https://doi.org/10.1101/2023.05.11.540294
Autor:
Katsuaki Hoshino, Hai Ying Fu, Atsushi Tobiume, Mari Ohmura-Hoshino, Masahiro Moritoki, Tadashi Sofue, Hiroyuki Saiga, Tetsuo Minamino, Keisuke Onishi
Publikováno v:
Clinical and Experimental Nephrology. 26:226-233
Galectin-9 (Gal-9) is a multifunctional lectin that moderates inflammation and organ damage. In this study, we tested whether Gal-9 has a protective role in the pathogenesis of endotoxemic acute kidney injury. We examined the levels of Gal-9 in contr
Autor:
Keisuke, Onishi, Hai Ying, Fu, Tadashi, Sofue, Atsushi, Tobiume, Masahiro, Moritoki, Hiroyuki, Saiga, Mari, Ohmura-Hoshino, Katsuaki, Hoshino, Tetsuo, Minamino
Publikováno v:
Clinical and experimental nephrology. 26(3)
Galectin-9 (Gal-9) is a multifunctional lectin that moderates inflammation and organ damage. In this study, we tested whether Gal-9 has a protective role in the pathogenesis of endotoxemic acute kidney injury.We examined the levels of Gal-9 in contro
Publikováno v:
International immunology. 34(3)
Type I IFNs (IFN-α and IFN-β), immunomodulatory cytokines secreted from activated plasmacytoid dendritic cells (pDCs), contribute to the innate defense against pathogenic infections and the pathogenesis of the autoimmune disease psoriasis vulgaris.
Autor:
Ken Ishii, Kiyoshi Takeda, Kensuke Miyake, Takashi Orimo, Yuri Fukuda-Ohta, Kei-ichi Katayama, Izumi Sasaki, Mariko Kitauchi, Yayoi Sato, Mio Morinaka, Toshiya Ozasa, Tsuneyasu Kaisho, Takashi Tanaka, Tomokazu Ohta, Katsuaki Hoshino, Takashi Satoh, Masahiro Yamamoto, Koichi Furukawa, Takako Yamaguchi, Etsushi Kuroda, Hiroaki Hemmi, Shinji Fukuda
Publikováno v:
International Immunology
Cholera toxin B (CTB) is a subunit of cholera toxin, a bacterial enterotoxin secreted by Vibrio cholerae and also functions as an immune adjuvant. However, it remains unclear how CTB activates immune cells. We here evaluated whether or how CTB induce