Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Katriona L. Hole"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-15 (2024)
Abstract Tauopathies are characterised by the pathological accumulation of misfolded tau. The emerging view is that toxic tau species drive synaptic dysfunction and potentially tau propagation before measurable neurodegeneration is evident, but the u
Externí odkaz:
https://doaj.org/article/b84b2ce52d414462b8e67e2f70fbe8f0
Autor:
Katriona L. Hole, Lydia E. Staniaszek, Gayathri Menon Balan, Jody M. Mason, Jon T. Brown, Robert J. Williams
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Aggregation of the microtubule-associated protein tau into paired helical filaments (PHFs) and neurofibrillary tangles is a defining characteristic of Alzheimer’s Disease. Various plant polyphenols disrupt tau aggregation in vitro but display poor
Externí odkaz:
https://doaj.org/article/7c25e2f2c9814601ab0b951a342a7015
Microglia are crucial players in the pathogenesis of late onset Alzheimer’s Disease (AD), with evidence for both deleterious and beneficial effects. Identifying interventions to modulate microglial responsiveness, to promote Amyloid β (Aβ) cleara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1661f66b781fbcc0678963c196617615
https://doi.org/10.1101/2023.05.24.542060
https://doi.org/10.1101/2023.05.24.542060
Autor:
Robert J. Williams, Katriona L. Hole
Publikováno v:
Brain Plasticity. 6:167-192
Attempts to develop a disease modifying intervention for Alzheimer’s disease (AD) through targeting amyloid β (Aβ) have so far been unsuccessful. There is, therefore, a need for novel therapeutics against alternative targets coupled with approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fe4507eaa4f0a42c71ea65ca9a39803
https://doi.org/10.3233/bpl-200098
https://doi.org/10.3233/bpl-200098
Autor:
Lydia E. Staniaszek, Gayathri Menon Balan, Robert J. Williams, Jody M. Mason, Katriona L. Hole, Jon T. Brown
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience, Vol 15 (2021)
Aggregation of the microtubule-associated protein tau into paired helical filaments (PHFs) and neurofibrillary tangles is a defining characteristic of Alzheimer’s Disease. Various plant polyphenols disrupt tau aggregation in vitro but display poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f010cc28c623fc0889565c09bef6251d
http://europepmc.org/articles/PMC8244787
http://europepmc.org/articles/PMC8244787
Autor:
Katriona L, Hole, Robert J, Williams
Publikováno v:
Brain Plasticity
Attempts to develop a disease modifying intervention for Alzheimer’s disease (AD) through targeting amyloid β (Aβ) have so far been unsuccessful. There is, therefore, a need for novel therapeutics against alternative targets coupled with approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a559b1dba8c1236a0c72cc912034691c
https://pubmed.ncbi.nlm.nih.gov/33782649
https://pubmed.ncbi.nlm.nih.gov/33782649