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An open label trial of anakinra to prevent respiratory failure in covid-19

Autor: Kyriazopoulou, E. Panagopoulos, P. Metallidis, S. Dalekos, G.N. Poulakou, G. Gatselis, N. Karakike, E. Saridaki, M. Loli, G. Stefos, A. Prasianaki, D. Georgiadou, S. Tsachouridou, O. Petrakis, V. Tsiakos, K. Kosmidou, M. Lygoura, V. Dareioti, M. Milionis, H. Papanikolaou, I.C. Akinosoglou, K. Myrodia, D.-M. Gravvani, A. Stamou, A. Gkavogianni, T. Katrini, K. Marantos, T. Trontzas, I.P. Syrigos, K. Chatzis, L. Chatzis, S. Vechlidis, N. Avgoustou, C. Chalvatzis, S. Kyprianou, M. van der Meer, J.W.M. Eugen-Olsen, J. Netea, M.G. Giamarellos-Bourboulis, E.J.

Background It was studied if early suPAR-guided anakinra treatment can prevent severe respiratory failure (SRF) of COVID-19. Methods 130 patients with suPAR ≥6 ng/ml were assigned to subcutaneous anakinra 100mg once daily for 10 days. Primary outco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::7413aa627084b09fd3d3170b07c20071
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2997204

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Reply to radermacher et al. On ‘‘serum hydrogen sulfide and outcome association in pneumonia by the SARS-CoV-2 coronavirus’’

Autor: Renieris, G. Katrini, K. Giamarellos-Bourboulis, E.J.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::5955804b5403364f93661fe2be0df8b1
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3103267

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Host cystathionine-γ lyase derived hydrogen sulfide protects against Pseudomonas aeruginosa sepsis

Autor: Renieris, G. Droggiti, D.-E. Katrini, K. Koufargyris, P. Gkavogianni, T. Karakike, E. Antonakos, N. Damoraki, G. Karageorgos, A. Sabracos, L. Katsouda, A. Jentho, E. Weis, S. Wang, R. Bauer, M. Szabo, C. Platoni, K. Kouloulias, V. Papapetropoulos, A. Giamarellos-Bourboulis, E.J.

Hydrogen sulfide (H2S) has recently been recognized as a novel gaseous transmitter with several anti-inflammatory properties. The role of host- derived H2S in infections by Pseudomonas aeruginosa was investigated in clinical and mouse models. H2S con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::4074d8a701bea80423f800074f98b6a0
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2999937

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Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

Autor: Kyriazopoulou, E. Huet, T. Cavalli, G. Gori, A. Kyprianou, M. Pickkers, P. Eugen-Olsen, J. Clerici, M. Veas, F. Chatellier, G. Kaplanski, G. Netea, M.G. Pontali, E. Gattorno, M. Cauchois, R. Kooistra, E. Kox, M. Bandera, A. Beaussier, H. Mangioni, D. Dagna, L. van der Meer, J.W.M. Giamarellos-Bourboulis, E.J. Hayem, G. Netea, M.G. van der Meer, J.W.M. Giamarellos-Bourboulis, E.J. Volpi, S. Sormani, M.P. Signori, A. Bozzi, G. Minoia, F. Aliberti, S. Grasselli, G. Alagna, L. Lombardi, A. Ungaro, R. Agostoni, C. Blasi, F. Costantino, G. Fracanzani, A.L. Montano, N. Peyvandi, F. Sottocorno, M. Muscatello, A. Filocamo, G. Papadopoulos, A. Mouktaroudi, M. Karakike, E. Saridaki, M. Gkavogianni, T. Katrini, K. Vechlidis, N. Avgoustou, C. Chalvatzis, S. Marantos, T. Damoulari, C. Damoraki, G. Ktena, S. Tsilika, M. Koufargyris, P. Karageorgos, A. Droggiti, D.-I. Koliakou, A. Poulakou, G. Tsiakos, K. Myrodia, D.-M. Gravvani, A. Trontzas, I.P. Syrigos, K. Kalomenidis, I. Kranidioti, E. Panagopoulos, P. Petrakis, V. Metallidis, S. Loli, G. Tsachouridou, O. Dalekos, G.N. Gatselis, N. Stefos, A. Georgiadou, S. Lygoura, V. Milionis, H. Kosmidou, M. Papanikolaou, I.C. Akinosoglou, K. Giannitsioti, E. Chrysos, G. Mavroudis, P. Sidiropoulou, C. Adamis, G. Fragkou, A. Rapti, A. Alexiou, Z. Symbardi, S. Masgala, A. Kostaki, K. Kostis, E. Samarkos, M. Bakakos, P. Tzavara, V. Dimakou, K. Tzatzagou, G. Chini, M. Kotsis, V. Tsoukalas, G. Bliziotis, I. Doumas, M. Argyraki, A. Kainis, I. Fantoni, M. Cingolani, A. Angheben, A. Cardellino, C.S. Castelli, F. Serino, F.S. Nicastri, E. Ippolito, G. Bassetti, M. Selmi, C. International Collaborative Group for Anakinra in COVID-19

Background: Anakinra might improve the prognosis of patients with moderate to severe COVID-19 (ie, patients requiring oxygen supplementation but not yet receiving organ support). We aimed to assess the effect of anakinra treatment on mortality in pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::a9acb0a5c15e9c11554aca5f19ae9e2c
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2999762

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Author Correction: Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial (Nature Medicine, (2021), 27, 10, (1752-1760), 10.1038/s41591-021-01499-z)

Autor: Kyriazopoulou, E. Poulakou, G. Milionis, H. Metallidis, S. Adamis, G. Tsiakos, K. Fragkou, A. Rapti, A. Damoulari, C. Fantoni, M. Kalomenidis, I. Chrysos, G. Angheben, A. Kainis, I. Alexiou, Z. Castelli, F. Serino, F.S. Tsilika, M. Bakakos, P. Nicastri, E. Tzavara, V. Kostis, E. Dagna, L. Koufargyris, P. Dimakou, K. Savvanis, S. Tzatzagou, G. Chini, M. Cavalli, G. Bassetti, M. Katrini, K. Kotsis, V. Tsoukalas, G. Selmi, C. Bliziotis, I. Samarkos, M. Doumas, M. Ktena, S. Masgala, A. Papanikolaou, I. Kosmidou, M. Myrodia, D.-M. Argyraki, A. Cardellino, C.S. Koliakou, K. Katsigianni, E.-I. Rapti, V. Giannitsioti, E. Cingolani, A. Micha, S. Akinosoglou, K. Liatsis-Douvitsas, O. Symbardi, S. Gatselis, N. Mouktaroudi, M. Ippolito, G. Florou, E. Kotsaki, A. Netea, M.G. Eugen-Olsen, J. Kyprianou, M. Panagopoulos, P. Dalekos, G.N. Giamarellos-Bourboulis, E.J.

In the version of this Article initially published, there was an error in the author affiliations. Specifically, affiliation 27, corresponding to author Carlo Selmi, has been corrected from “Humanitas Research Hospital, Milan, Italy” to read: “

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::0c0f2bb2b59336981708f2ef5a7582cd
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3076595

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A novel optical biosensor for the early diagnosis of sepsis and severe Covid-19: the PROUD study

Autor: Doulou, S. Leventogiannis, K. Tsilika, M. Rodencal, M. Katrini, K. Antonakos, N. Kyprianou, M. Karofylakis, E. Karageorgos, A. Koufargyris, P. Christopoulos, G. Kassianidis, G. Stamatelopoulos, K. Newberry, R. Giamarellos-Bourboulis, E.J.

Background: The accuracy of a new optical biosensor (OB) point-of-care device for the detection of severe infections is studied. Methods: The OB emits different wavelengths and outputs information associated with heart rate, pulse oximetry, levels of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::14c944312b1738bf914cc0863067c703
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3103473

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Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

Autor: Giamarellos-Bourboulis, E.J. Netea, M.G. Rovina, N. Akinosoglou, K. Antoniadou, A. Antonakos, N. Damoraki, G. Gkavogianni, T. Adami, M.-E. Katsaounou, P. Ntaganou, M. Kyriakopoulou, M. Dimopoulos, G. Koutsodimitropoulos, I. Velissaris, D. Koufargyris, P. Karageorgos, A. Katrini, K. Lekakis, V. Lupse, M. Kotsaki, A. Renieris, G. Theodoulou, D. Panou, V. Koukaki, E. Koulouris, N. Gogos, C. Koutsoukou, A.

Proper management of COVID-19 mandates better understanding of disease pathogenesis. Giamarellos-Bourboulis et al. describe two main features preceding severe respiratory failure associated with COVID-19: the first is macrophage activation syndrome;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::c6a0b5af2e70b064a296e86b098cb962
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3000193

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Akademický článek

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Akademický článek

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