Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Katrina W. Copeland"'
Autor:
Emily A. Peterson, Stephanie D. Geuns-Meyer, Matthew Weiss, Hongbing Huang, Katrina W. Copeland, Violeta Yu, Erin F. DiMauro, Hua Gao, Alessandro Boezio, Russell Graceffa, Daniel S. La, Hakan Gunaydin, Robert T. Fremeau, Christiane Boezio, Margaret Chu-Moyer, Joseph Ligutti, Bryan D. Moyer, Kristin L. Andrews, Robert S. Foti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2103-2108
Recently, the identification of several classes of aryl sulfonamides and acyl sulfonamides that potently inhibit NaV1.7 and demonstrate high levels of selectivity over other NaV isoforms have been reported. The fully ionizable nature of these inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::857963b5479482ddc3b3b092657acc77
https://doi.org/10.1016/j.bmcl.2018.04.035
https://doi.org/10.1016/j.bmcl.2018.04.035
Autor:
Karen Rex, Douglas A. Whittington, David Bauer, Steven F. Bellon, Jean-Christophe Harmange, Martin A. Broome, Alessandro Boezio, Christiane Boezio, Karina R. Vaida, Deborah Choquette, Isabelle Dussault, Katrina W. Copeland, Emily A. Peterson, Yohannes Teffera, Roman Shimanovich, Brian K. Albrecht, Richard T. Lewis, Michele Potashman, Jingzhou Liu, Julia Lohman, Angela Coxon, Min-Hwa Jasmine Lin, Satoko Hirai
Publikováno v:
Journal of Medicinal Chemistry. 59:2328-2342
Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, we report the discovery of compound 23 (AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d16401f5e9358f2456fce2725cd044c7
https://doi.org/10.1021/acs.jmedchem.5b01716
https://doi.org/10.1021/acs.jmedchem.5b01716
Autor:
Alessandro A, Boezio, Kristin, Andrews, Christiane, Boezio, Margaret, Chu-Moyer, Katrina W, Copeland, Erin F, DiMauro, Robert S, Foti, Robert T, Fremeau, Hua, Gao, Stephanie, Geuns-Meyer, Russell F, Graceffa, Hakan, Gunaydin, Hongbing, Huang, Daniel S, La, Joseph, Ligutti, Bryan D, Moyer, Emily A, Peterson, Violeta, Yu, Matthew M, Weiss
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(11)
Recently, the identification of several classes of aryl sulfonamides and acyl sulfonamides that potently inhibit Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::262d2c43fc3730e01bab845e9286e105
https://pubmed.ncbi.nlm.nih.gov/29709252
https://pubmed.ncbi.nlm.nih.gov/29709252
Autor:
Alessandro A, Boezio, Katrina W, Copeland, Karen, Rex, Brian, K Albrecht, David, Bauer, Steven F, Bellon, Christiane, Boezio, Martin A, Broome, Deborah, Choquette, Angela, Coxon, Isabelle, Dussault, Satoko, Hirai, Richard, Lewis, Min-Hwa Jasmine, Lin, Julia, Lohman, Jingzhou, Liu, Emily A, Peterson, Michele, Potashman, Roman, Shimanovich, Yohannes, Teffera, Douglas A, Whittington, Karina R, Vaida, Jean-Christophe, Harmange
Publikováno v:
Journal of medicinal chemistry. 59(6)
Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, we report the discovery of compound 23 (AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d316417441481eaad06208d8a5d80b98
https://pubmed.ncbi.nlm.nih.gov/26812066
https://pubmed.ncbi.nlm.nih.gov/26812066
Autor:
Kevin Gaida, Marissa van der Valk, BaoXi Gao, Lei Cao, David J. Matson, Jean-Christophe Harmange, Todd Juan, Katrina W. Copeland, Stephanie Springer, Markus Hierl, Jeff S. McDermott, Dan Waldon, Hong Deng, Brian K. Albrecht, Wenhong Guo, Kristie Clarkin, Hung Q. Nguyen, Johannes Knop, Sonya G. Lehto, Stefan I. McDonough, Alessandro Boezio, Annika B. Malmberg
Publikováno v:
Pain. 149:33-49
Nicotinic acetylcholine receptors (nAChRs) are longstanding targets for a next generation of pain therapeutics, but the nAChR subtypes that govern analgesia remain unknown. We tested a series of nicotinic agonists, including many molecules used or tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e82c873e17496432e602d0d45512c2
https://doi.org/10.1016/j.pain.2010.01.007
https://doi.org/10.1016/j.pain.2010.01.007
Autor:
Christiane Boezio, Michele Potashman, Yohannes Teffera, Brian K. Albrecht, Julia Lohman, Karina R. Vaida, Alessandro Boezio, Emily A. Peterson, Steven F. Bellon, Deborah Choquette, David Bauer, Katrina W. Copeland, Isabelle Dussault, Roman Shimanovich, Min-Hwa Jasmine Lin, Martin A. Broome, Richard T. Lewis, Jean-Christophe Harmange, Karen Rex, Douglas A. Whittington, Jingzhou Liu
Publikováno v:
Journal of medicinal chemistry. 58(5)
The overexpression of c-Met and/or hepatocyte growth factor (HGF), the amplification of the MET gene, and mutations in the c-Met kinase domain can activate signaling pathways that contribute to cancer progression by enabling tumor cell proliferation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8df9c5e2d13e9c214982a8d6426b0c7
https://pubmed.ncbi.nlm.nih.gov/25901648
https://pubmed.ncbi.nlm.nih.gov/25901648
Autor:
Stephanie D. Geuns-Meyer, Qian Wan, Alessandro Boezio, Weiya Wang, Beth D. Youngblood, Eugene Cheung, Sonya G. Lehto, Josie Lee, Narender R. Gavva, Philip R. Olivieri, Katrina W. Copeland, Laurie B. Schenkel, Mary C. Wells
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(15)
The transient receptor potential ankyrin 1 (TRPA1) channel is activated by noxious stimuli including chemical irritants and endogenous inflammatory mediators. Antagonists of this channel are currently being investigated for use as therapeutic agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682e10096e4f3e9a3a0d612d5ca6936b
https://pubmed.ncbi.nlm.nih.gov/24953819
https://pubmed.ncbi.nlm.nih.gov/24953819
Autor:
Alan C. Cheng, Ti Cai, Barbara Grubinska, Daniel S. La, Tammy L. Bush, Yohannes Teffera, Joseph L. Kim, Christiane Boezio, Michele Potashman, Russell Graceffa, Erin L. Mullady, Paul S. Andrews, James R. Coats, Katrina W. Copeland, Alessandro Boezio, Emily A. Peterson, Richard T. Lewis, John Stellwagen, Jingzhou Liu, Deborah Choquette, Karina Romero, Adria E. Colletti, Shuyan Yi, Mary K. Stanton, Paul L. Shaffer, Michelle DuPont
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(15)
mTOR is a critical regulator of cellular signaling downstream of multiple growth factors. The mTOR/PI3K/AKT pathway is frequently mutated in human cancers and is thus an important oncology target. Herein we report the evolution of our program to disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b4513ddf80e3dd0091b6571268da1c
https://pubmed.ncbi.nlm.nih.gov/22765895
https://pubmed.ncbi.nlm.nih.gov/22765895
Autor:
Philip R. Olivieri, Barbara Grubinska, Alan C. Cheng, Alessandro Boezio, Katrina W. Copeland, Yohannes Teffera, Daniel S. La, Xuhai Be, James R. Coats, Paul S. Andrews, Jean-Christophe Harmange, Joseph L. Kim, Ti Cai, Emily A. Peterson, Michelle DuPont, Douglas A. Whittington, Laurie B. Schenkel, Adria E. Colletti, Mary K. Stanton, Tammy L. Bush, Russell Graceffa, Erin L. Mullady
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(7)
mTOR is part of the PI3K/AKT pathway and is a central regulator of cell growth and survival. Since many cancers display mutations linked to the mTOR signaling pathway, mTOR has emerged as an important target for oncology therapy. Herein, we report th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7455263dc4eb0802f5be9fd3b94ee6c6
https://pubmed.ncbi.nlm.nih.gov/21376583
https://pubmed.ncbi.nlm.nih.gov/21376583
Autor:
Danielle M. Zurcher, Daniel Waldon, Katrina W. Copeland, Jingzhou Liu, Adria E. Colletti, Yohannes Teffera, Zhiyang Zhao
Publikováno v:
Chemical research in toxicology. 23(12)
High-resolution accurate MS with an LTQ-Orbitrap was used to identify quinone imine metabolites derived from the 5-hydroxy (5-OH) and 4 prime-hydroxy (4'-OH) glutathione conjugates of diclofenac in rat bile. The initial quinone imine metabolites form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b0269c1c66b14cedc13df9a310332d
https://pubmed.ncbi.nlm.nih.gov/21053927
https://pubmed.ncbi.nlm.nih.gov/21053927