Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Katrina Sweeney"'
Autor:
Patrick B. Thomas, Saeid Alinezhad, Andre Joshi, Katrina Sweeney, Brian W. C. Tse, Gregor Tevz, Stephen McPherson, Colleen C. Nelson, Elizabeth D. Williams, Ian Vela
Publikováno v:
Current Oncology, Vol 30, Iss 11, Pp 9437-9447 (2023)
Patient-derived xenograft (PDX) models have been established as important preclinical cancer models, overcoming some of the limitations associated with the use of cancer cell lines. The utility of prostate cancer PDX models has been limited by an ina
Externí odkaz:
https://doaj.org/article/21c1299ac58a487cb97e5ad972e9f1c4
Autor:
Gunnel Halldén, Nick R. Lemoine, Celina Costas, Katrina Sweeney, Virginie Adam, Eva Yanover, Daniel Öberg
Supplementary Data from Improved Potency and Selectivity of an Oncolytic E1ACR2 and E1B19K Deleted Adenoviral Mutant in Prostate and Pancreatic Cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d297f4986fcfc264dd343175f8ff3d1
https://doi.org/10.1158/1078-0432.22440346
https://doi.org/10.1158/1078-0432.22440346
Autor:
Gunnel Halldén, Nick R. Lemoine, Enrique Miranda, Derek Davies, Daniel Öberg, Katrina Sweeney, Stephan Leitner
Supplementary Figures S1-S5 from Oncolytic Adenoviral Mutants with E1B19K Gene Deletions Enhance Gemcitabine-induced Apoptosis in Pancreatic Carcinoma Cells and Anti-Tumor Efficacy In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240f2fac090c3ccb6337f0f45bbf474a
https://doi.org/10.1158/1078-0432.22440381
https://doi.org/10.1158/1078-0432.22440381
Autor:
Gunnel Halldén, Nick R. Lemoine, Celina Costas, Katrina Sweeney, Virginie Adam, Eva Yanover, Daniel Öberg
Purpose: Replication-selective oncolytic adenoviruses are a promising class of tumor-targeting agents with proven safety in hundreds of patients. However, clinical responses have been limited and viral mutants with higher potency are needed. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62986b4e64218274d34d45126f478a11
https://doi.org/10.1158/1078-0432.c.6517690.v1
https://doi.org/10.1158/1078-0432.c.6517690.v1
Autor:
Gunnel Halldén, Nick R. Lemoine, Enrique Miranda, Derek Davies, Daniel Öberg, Katrina Sweeney, Stephan Leitner
Purpose: Pancreatic adenocarcinoma is a rapidly progressive malignancy that is highly resistant to current chemotherapeutic modalities and almost uniformly fatal. We show that a novel targeting strategy combining oncolytic adenoviral mutants with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc5029746fc668de01fcb8e38d1b7c1
https://doi.org/10.1158/1078-0432.c.6517719
https://doi.org/10.1158/1078-0432.c.6517719
Autor:
Gunnel Halldén, Katrina Sweeney
Publikováno v:
Oncolytic Virotherapy
Prostate cancer is a leading cause of cancer-related death and morbidity in men in the Western world. Tumor progression is dependent on functioning androgen receptor signaling, and initial administration of antiandrogens and hormone therapy (androgen
Autor:
Colleen C. Nelson, Katrina Sweeney, Meenakshi Malhotra, Brett G. Hollier, Raphael Darcy, Caitriona M. O'Driscoll, James C. Evans
Publikováno v:
International journal of pharmaceutics. 532(1)
The main barrier to the development of an effective RNA interference (RNAi) therapy is the lack of a suitable delivery vector. Modified cyclodextrins have emerged in recent years for the delivery of siRNA. In the present study, a folate-targeted amph
Autor:
Heike Müller, Virginie Adam, Na Ra Kang, Nicholas R. Lemoine, Gunnel Halldén, Maria Ekblad, Katrina Sweeney, Kristina Hammarén Busch, Camilla Tørnqvist Johnsen
Publikováno v:
Human Gene Therapy. 23:1003-1015
AdΔΔ is an oncolytic adenoviral mutant that has been engineered to selectively target tumors with deregulated cell cycle and apoptosis pathways. AdΔΔ potentiates apoptotic cell death induced by drugs, including mitoxantrone and docetaxel, which a
Autor:
Sarah P. Blagden, Sadaf Ghaem-Maghami, Andrea J. Berman, Normala Abd-Latip, Roni M. Lahr, Jennifer H. Steel, Hiba A. Al-Ashtal, Justin Weir, Eric O. Aboagye, Manuela Mura, Mona El-Bahrawy, Haonan Lu, T.G. Hopkins, Katrina Sweeney
Publikováno v:
Nucleic Acids Research
RNA-binding proteins (RBPs) are increasingly identified as post-transcriptional drivers of cancer progression. The RBP LARP1 is an mRNA stability regulator, and elevated expression of the protein in hepatocellular and lung cancers is correlated with
Autor:
Philip A. Gregory, Margaret M. Centenera, Lisa M. Butler, Brett G. Hollier, Rajdeep Das, Nataly Stylianou, Wayne D. Tilley, Scott L. Townley, Adrienne R. Hanson, Amina Zoubeidi, Gregory J. Goodall, Carolina Soekmadji, Katrina Sweeney, Colleen C. Nelson, Isabel Coutinho, Lidija Jovanovic, Luke A. Selth
Publikováno v:
Europe PubMed Central
MicroRNA-375 (miR-375) is frequently elevated in prostate tumors and cell-free fractions of patient blood, but its role in genesis and progression of prostate cancer is poorly understood. In this study, we demonstrated that miR-375 is inversely corre