Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Katrina Soderquest"'
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Akademický článek
Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.
Autor: Katrina Soderquest, Arnulf Hertweck, Claudia Giambartolomei, Stephen Henderson, Rami Mohamed, Rimma Goldberg, Esperanza Perucha, Lude Franke, Javier Herrero, Vincent Plagnol, Richard G Jenner, Graham M Lord
Publikováno v: PLoS Genetics, Vol 13, Iss 2, p e1006587 (2017)
The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity. The transcription factor T-bet (TBX21) specifies the Th1 lineage an
Externí odkaz: https://doaj.org/article/1b047c1f9aaf46738e2b7b4684f706e9
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2
MAGI2 Mutations Cause Congenital Nephrotic Syndrome
Autor: P. Dean, Graham M. Lord, Caroline Jones, Carol Inward, Gavin I. Welsh, Ania Koziell, Moin A. Saleem, Maggie Williams, Hugh J. McCarthy, Ruth Rollason, Katrina Soderquest, Michael A. Simpson, Elizabeth Colby, Agnieszka Bierzynska
Publikováno v: Bierzynska, A, Soderquest, K, Dean, P, Colby, E, Rollason, R, Jones, C, Inward, C, McCarthy, H, Simpson, M A, Lord, G M, Williams, M, Welsh, G, Koziell, A & Saleem, M 2017, ' MAGI2 Mutations Cause Congenital Nephrotic Syndrome ', Journal of the American Society of Nephrology, vol. 28, no. 5, pp. 1614-1621 . https://doi.org/10.1681/ASN.2016040387
Bierzynska, A, Soderquest, K, Dean, P, Colby, E, Rollason, R, Jones, C, Inward, C D, McCarthy, H J, Simpson, M A, Lord, G M, Williams, M, Welsh, G I, Koziell, A B & Saleem, M A 2017, ' MAGI2 mutations cause congenital nephrotic syndrome ', Journal of the American Society of Nephrology, vol. 28, no. 5, pp. 1614-1621 . https://doi.org/10.1681/ASN.2016040387
Steroid-resistant nephrotic syndrome (SRNS), a heterogeneous disorder of the renal glomerular filtration barrier, results in impairment of glomerular permselectivity. Inheritance of genetic SRNS may be autosomal dominant or recessive, with a subset o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5969c0133dfd87bda0271297773ebc45
https://hdl.handle.net/1983/7cef385e-33c4-4af0-aa5f-8112ecc1fe55
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3
Genomic and clinical profiling of a national Nephrotic Syndrome cohort advocates a precision medicine approach to disease management
Autor: Katrina Soderquest, Ethan S Sen, Stephen D. Marks, Michael A. Simpson, Milos Ognjanovic, Caroline Jones, Rodney D. Gilbert, David Hughes, Gavin I. Welsh, Larissa Kerecuk, Hugh J. McCarthy, Manish D. Sinha, Agnieszka Bierzynska, Elizabeth Colby, Shivram Hegde, Moin A. Saleem, Nicholas J. A. Webb, Graham M. Lord, Wen Y. Ding, Sally Feather, Martin Christian, Ania Koziell, Marwa M. Nabhan
Publikováno v: Bierzynska, A, McCarthy, H, Soderquest, K, Sen, E, Colby, E, Ding, W, Nabhan, M, Kerecuk, L, Welsh, G, Saleem, M, Hedge, S, Hughes, D, Marks, S, Feather, S, Jones, C, Webb, N J A, Ognjanovic, M, Christian, M, Gilbert, R D, Sinha, M, Lord, G M, Simpson, M A & Koziell, A 2017, ' Genomic and clinical profiling of a national Nephrotic Syndrome cohort advocates a precision medicine approach to disease management ', Kidney International, vol. 91, no. 4, pp. 937–947 . https://doi.org/10.1016/j.kint.2016.10.013
Steroid Resistant Nephrotic Syndrome (SRNS) in children and young adults has differing etiologies with monogenic disease accounting for 2.9–30% in selected series. Using whole exome sequencing we sought to stratify a national population of children
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c233c30b48723bfe6a5827875b2d2e9
https://research-information.bris.ac.uk/en/publications/c730c0d6-5527-435a-8c27-a99fd990a0e8
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4
Monocytes control natural killer cell differentiation to effector phenotypes
Autor: Thierry Walzer, Nico van Rooijen, Frederic Geissmann, Nick Powell, Carmelo Luci, Andrés Hidalgo, Graham M. Lord, Katrina Soderquest, Alfonso Martín-Fontecha
Publikováno v: Blood, 117(17), 4511-4518. American Society of Hematology
Europe PubMed Central
Soderquest, K, Powell, N, Luci, C, van Rooijen, N, Hidalgo, A, Geissmann, F, Walzer, T, Lord, G M & Martin-Fontecha, A 2011, ' Monocytes control natural killer cell differentiation to effector phenotypes ', Blood, vol. 117, no. 17, pp. 4511-4518 . https://doi.org/10.1182/blood-2010-10-312264
Natural killer (NK) cells play a major role in immunologic surveillance of cancer. Whether NK-cell subsets have specific roles during antitumor responses and what the signals are that drive their terminal maturation remain unclear. Using an in vivo m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63652edb39470d33e51ebf00c7cee850
https://doi.org/10.1182/blood-2010-10-312264
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5
Genes and podocytes - new insights into mechanisms of podocytopathy
Autor: Katrina Soderquest, Ania Koziell, Agnieszka Bierzynska
Publikováno v: Frontiers in Endocrinology
After decades of primarily morphological study, positional cloning of the NPHS1 gene was the landmark event that established aberrant podocyte genetics as a pivotal cause of malfunction of the glomerular filter. This ended any uncertainty whether gen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31a0a156f1af3595323007b698b5c8f
https://pubmed.ncbi.nlm.nih.gov/25667580
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6
Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses
Autor: Bojan Polić, Thierry Walzer, Biljana Zafirova, Eric Vivier, Alfonso Martín-Fontecha, Linda S. Klavinskis, Katrina Soderquest, Graham M. Lord
Publikováno v: Journal of Immunology
Journal of Immunology, 2011, 186 (6), pp.3304-8. ⟨10.4049/jimmunol.1004122⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2011, 186 (6), pp.3304-8. ⟨10.4049/jimmunol.1004122⟩
It is uncertain whether NK cells modulate T cell memory differentiation. By using a genetic model that allows the selective depletion of NK cells, we show in this study that NK cells shape CD8+ T cell fate by killing recently activated CD8+ T cells i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b635309d5cca4e09d2f9e71c00235643
https://hal.science/hal-00608178
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7
Strategies for Translational Research in the United Kingdom
Autor: Graham M. Lord, Katrina Soderquest
Publikováno v: Science Translational Medicine. 2
In the United Kingdom, many foundations and institutions and the government have made substantial investments in translational research. We examine the structures that surround this support and consider some of the results of this prodigious push tow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1adc653d6fa99be4af8e2d0c04da2ac
https://doi.org/10.1126/scitranslmed.3001129
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9
Response to Comment on 'Cutting Edge: CD8+ T Cell Priming in the Absence of NK Cells Leads to Enhanced Memory Responses'
Autor: Katrina Soderquest, Alfonso Martín-Fontecha, Graham M. Lord
Publikováno v: The Journal of Immunology. 186:6071-6072
In our recent publication in The Journal of Immunology , we proposed that NK cells shape CD8+ T cell responses by migrating to s.c. lymph nodes and by killing Ag-primed CD8+ T cells. We are happy to reply to the questions raised by Dr. Manjili and Dr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a34fdcd8248ad55fa3d54977fc2d717
https://doi.org/10.4049/jimmunol.1190018
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