Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Katrina Northrop"'
Autor:
Eric B. Springman, Michael Karpusas, Katrina Northrop, Marina Bukhtiyarova, Haridasan V M Namboodiri
Publikováno v:
Biochemistry. 46:5687-5696
In order to study the role of Phe169 in p38alpha MAP kinase structure and function, wild-type p38alpha and five p38alpha DFG motif mutants were examined in vitro for phosphorylation by MKK6, kinase activity toward ATF2 substrate, thermal stability, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276d85e70cac7499af95f2c077d809c3
https://doi.org/10.1021/bi0622221
https://doi.org/10.1021/bi0622221
Autor:
Gary A. Flynn, Duyan Nguyen, Xiaomei Chai, Brandon A. Campbell, Marina Bukhtiyarova, Enrique Luis Michelotti, Eric B. Springman, Rupa Shetty, Variketta Namboodiri, Frank Hollinger, Katrina Northrop, Ted T. Fujimoto, Martha Jean Kelly, Michael Karpusas, Kristofer K. Moffett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5274-5279
Two new classes of diphenylether inhibitors of p38alpha MAP kinase are described. Both chemical classes are based on a common diphenylether core that is identified by simulated fragment annealing as one of the most favored chemotypes within a promine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86ba9e3cf8b549da419b75bf00cb5c5
https://doi.org/10.1016/j.bmcl.2005.08.038
https://doi.org/10.1016/j.bmcl.2005.08.038
Autor:
Eric B. Springman, David Casper, Xiaomei Chai, Katrina Northrop, Marina Bukhtiyarova, Michael Karpusas
Publikováno v:
Protein Expression and Purification. 37:154-161
p38alpha mitogen-activated protein (MAP) kinase is widely expressed in many mammalian tissues and is activated as a part of signal transduction cascades that respond to inflammatory stimuli. The activation of p38 is known to trigger various biologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b03a0bd9899d07b040311b6945ef359
https://doi.org/10.1016/j.pep.2004.05.017
https://doi.org/10.1016/j.pep.2004.05.017