Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Katrina N Estep"'
Autor:
Rafael Jesus Fernandez, Zachary JG Gardner, Katherine J Slovik, Derek C Liberti, Katrina N Estep, Wenli Yang, Qijun Chen, Garrett T Santini, Javier V Perez, Sarah Root, Ranvir Bhatia, John W Tobias, Apoorva Babu, Michael P Morley, David B Frank, Edward E Morrisey, Christopher J Lengner, F Brad Johnson
Publikováno v:
eLife, Vol 11 (2022)
Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in telomere maintenance leading to very short telomeres and the premature onset of certain age-related diseases, including pulmonary fibrosis (PF). PF is thought to
Externí odkaz:
https://doaj.org/article/5a2e0adc44d4496d8818d07ddfebb226
Autor:
Elisia D. Tichy, Ji-Hyung Lee, Grant Li, Katrina N. Estep, F. Brad Johnson, Foteini Mourkioti
Publikováno v:
npj Microgravity, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Astronauts are exposed to harsh conditions, including cosmic radiation and microgravity. Spaceflight elongates human telomeres in peripheral blood, which shorten upon return to Earth and approach baseline levels during postflight recovery. A
Externí odkaz:
https://doaj.org/article/49296aaceaad41838d28e1fc4c254dfa
Although mechanisms of telomere protection are well-defined in differentiated cells, it is poorly understood how stem cells sense and respond to telomere dysfunction. Recent efforts have characterized the DNA damage response (DDR) following progressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc05cec2ed5993ab5d0c8909420bd3ce
https://doi.org/10.1101/2023.01.19.524780
https://doi.org/10.1101/2023.01.19.524780
Autor:
Yuhua Tian, Xin Wang, Zvi Cramer, Joshua Rhoades, Katrina N. Estep, Xianghui Ma, Stephanie Adams Tzivelekidis, Bryson W Katona, F Brad Johnson, Zhengquan Yu, Mario Andres Blanco, Christopher Lengner, Ning Li
Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally, with the majority of cases initiated by inactivation of the APC tumor suppressor. This results in the constitutive transcriptional activation of the canonical WNT signal tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::323fedb8ecb32d3a33efc381510be6f8
https://doi.org/10.1101/2022.07.26.501557
https://doi.org/10.1101/2022.07.26.501557
Autor:
Rafael Jesus Fernandez, Zachary JG Gardner, Katherine J Slovik, Derek C Liberti, Katrina N Estep, Wenli Yang, Qijun Chen, Garrett T Santini, Javier V Perez, Sarah Root, Ranvir Bhatia, John W Tobias, Apoorva Babu, Michael P Morley, David B Frank, Edward E Morrisey, Christopher J Lengner, F Brad Johnson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fa3abc76cc227dd10c1e048dbbb2f18
https://doi.org/10.7554/elife.64430.sa2
https://doi.org/10.7554/elife.64430.sa2
Autor:
Luigi Ferrucci, Katrina N Estep, Thomas J. Butler, Robert W. Maul, David Schlessinger, Andrew R. Wood, Marcus A. Tuke, Joshua A. Sommers, Thomas A. Guilliam, Francesco Cucca, Daniel F. Bogenhagen, Alicia K. Byrd, Aidan J. Doherty, Stefania Bandinelli, Robert M. Brosh, Sanjay Kumar Bharti, Elena Yakubovskaya, Miguel Garcia-Diaz, Ann Zenobia Moore, Jun Ding, Kevin D. Raney
Publikováno v:
Hum Mol Genet
As the powerhouses of the eukaryotic cell, mitochondria must maintain their genomes which encode proteins essential for energy production. Mitochondria are characterized by guanine-rich DNA sequences that spontaneously form unusual three-dimensional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afb2d119be5d18078f77c07bad4b4f8
https://doi.org/10.1093/hmg/ddaa043
https://doi.org/10.1093/hmg/ddaa043
Publikováno v:
Current Medicinal Chemistry. 26:2881-2897
Background:Guanine-rich DNA can fold into highly stable four-stranded DNA structures called G-quadruplexes (G4). In recent years, the G-quadruplex field has blossomed as new evidence strongly suggests that such alternately folded DNA structures are l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed77f771a8bdd7710c30b6b0d9c1ab5a
https://doi.org/10.2174/0929867324666171116123345
https://doi.org/10.2174/0929867324666171116123345
Autor:
Qijun Chen, Ranvir Bhatia, Christopher J. Lengner, Michael Morley, Zachary J G Gardner, Katrina N Estep, Wenli Yang, David B. Frank, Javier V Perez, Apoorva Babu, F. Brad Johnson, Rafael Fernandez, Garrett T. Santini, Sarah Root, Derek C. Liberti, Edward E. Morrisey, Katherine J. Slovik, John W. Tobias
SummaryDyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in telomere maintenance leading to very short telomeres and the premature onset of certain age-related diseases, including pulmonary fibrosis (PF). PF is thou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd16f2d025fe270fe6d94f4e09b25bab
https://doi.org/10.1101/2020.10.28.358887
https://doi.org/10.1101/2020.10.28.358887
Autor:
Rafael Jesus Fernandez, Zachary JG Gardner, Katherine J Slovik, Derek C Liberti, Katrina N Estep, Wenli Yang, Qijun Chen, Garrett T Santini, Javier V Perez, Sarah Root, Ranvir Bhatia, John W Tobias, Apoorva Babu, Michael P Morley, David B Frank, Edward E Morrisey, Christopher J Lengner, F Brad Johnson
Publikováno v:
eLife. 11
Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in telomere maintenance leading to very short telomeres and the premature onset of certain age-related diseases, including pulmonary fibrosis (PF). PF is thought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972265b71fa2862cb9eca0c00ccd2935
https://pubmed.ncbi.nlm.nih.gov/35559731
https://pubmed.ncbi.nlm.nih.gov/35559731
Autor:
Robert M. Brosh, Katrina N Estep
Helicases are molecular motors that play central roles in nucleic acid metabolism. Mutations in genes encoding DNA helicases of the RecQ and iron–sulfur (Fe–S) helicase families are linked to hereditary disorders characterized by chromosomal inst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36e01108de486a022717d700d7dbac0
https://europepmc.org/articles/PMC5863537/
https://europepmc.org/articles/PMC5863537/