Výsledky vyhledávání - "Katrina Madden"

Mycobacterium tuberculosis infection triggers epigenetic changes that are enriched in a type I IFN signature

Autor: Katrina Madden, Rayan El Hamra, Stefania Berton, Jake Felker, Gonzalo G Alvarez, Alexandre Blais, Jim Sun

Publikováno v: microLife. 4

Tuberculosis, a deadly infectious lung disease caused by Mycobacterium tuberculosis (Mtb), remains the leading cause of bacterial disease-related deaths worldwide. Mtb reprograms and disables key antibacterial response pathways, many of which are reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d53de7ba69ce6c12a752c06447531ca8
https://doi.org/10.1093/femsml/uqad006

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Transcriptome and chromatin accessibility mapping reveals a type I Interferon response triggered by Mycobacterium tuberculosis infection

Autor: Katrina Madden, Rayan El Hamra, Stefania Berton, Gonzalo G. Alvarez, Alexandre Blais, Jim Sun

Tuberculosis, a deadly infectious lung disease caused by Mycobacterium tuberculosis (Mtb), remains the leading cause of bacterial disease-related deaths worldwide. The success of Mtb as a human pathogen depends on its ability to manipulate host immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bfede1928fb2423e7e51b60d49cd720
https://doi.org/10.1101/2022.08.11.503537

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Surveying the Epigenetic Landscape of Tuberculosis in Alveolar Macrophages

Autor: Katrina Madden, Yi Chu Liang, Nusrah Rajabalee, Gonzalo G. Alvarez, Jim Sun

Publikováno v: Infect Immun

Tuberculosis (TB) remains the leading cause of bacterial disease-related death and is among the top 10 overall causes of death worldwide. The complex nature of this infectious lung disease has proven difficult to treat, and significant research effor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cb78f9231aff5e4e8c6ce91e3c2aab
https://doi.org/10.1128/iai.00522-21

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A Pharmacophore-Based Approach to Demonstrating the Scope of Alcohol Dehydrogenases

Autor: Holly Reeve, Kylie Vincent, Angela Russell, Kouji Urata, Peter M.T. Todd, Katrina Madden

Barriers to the ready adoption of biocatalysis into asymmetric synthesis for early stage medicinal chemistry are addressed, using ketone reduction by alcohol dehydrogenase as a model reaction. An efficient substrate screening approach is used to show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::349b11e03ef5bcc2d7b7a41664756318
https://doi.org/10.26434/chemrxiv.13134767

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