Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Katrina Macaulay"'
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15845 (2011)
Over-activity and elevated expression of glycogen synthase kinase-3 (GSK-3) has been implicated in the etiology of insulin resistance and Type 2 diabetes. Administration of specific GSK-3 inhibitors to diabetic or obese rodent models improves glycaem
Externí odkaz:
https://doaj.org/article/2ddb5f7c9dda4e67af6605647de1a933
Autor:
Rajendra Dobriyal, Peter Murray, Katrina MacAulay, Maria A M Spreeuwenberg, Hanny M. Boers, David J. Mela
Publikováno v:
British Journal of Nutrition. 117:386-394
The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide, including in developing countries, particularly in South Asia. Intakes of foods generating a high postprandial glucose (PPG) response have been positively associated with T2DM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094cd89706147ad701eb8180e3997b9d
https://doi.org/10.1017/s0007114517000277
https://doi.org/10.1017/s0007114517000277
Autor:
Ian F. Godsland, Mark John Berry, Peter Murray, Katrina MacAulay, Duncan Talbot, Della Hyliands, Theo P. J. Mulder, H. Frances J. Bligh, John Casey, Gary Frost, Karl John Hunter
Publikováno v:
British Journal of Nutrition. 113:574-584
There is evidence for health benefits from ‘Palaeolithic’ diets; however, there are a few data on the acute effects of rationally designed Palaeolithic-type meals. In the present study, we used Palaeolithic diet principles to construct meals comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57faaff24fdd1067e54a8c0cb3da5a5
https://doi.org/10.1017/s0007114514004012
https://doi.org/10.1017/s0007114514004012
Autor:
Bradley W. Doble, Daniel J. Drucker, Satish Patel, Katrina MacAulay, Elaine M. Sinclair, James R. Woodgett
Publikováno v:
Molecular and Cellular Biology. 28:6314-6328
Dysregulation of the protein kinase glycogen synthase kinase 3 (GSK-3) has been implicated in the development of type 2 diabetes mellitus. GSK-3 protein expression and kinase activity are elevated in diabetes, while selective GSK-3 inhibitors have sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cd9a1ea516b9877136165ce0ca22fd
https://doi.org/10.1128/mcb.00763-08
https://doi.org/10.1128/mcb.00763-08
Autor:
Bradley W. Doble, Hind Lal, Risto Kerkelä, Morgan DeCaul, Jianliang Song, Yingxin Li, Erhe Gao, Katrina MacAulay, Thomas Force, Xiying Shang, Jibin Zhou, John L. Farber, Xiongwen Chen, Walter J. Koch, James R. Woodgett
The glycogen synthase kinase-3 (GSK-3) family of serine/threonine kinases consists of 2 highly related isoforms, alpha and beta. Although GSK-3beta has an important role in cardiac development, much remains unknown about the function of either GSK-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46605a364e53d40de994872e64c97054
https://europepmc.org/articles/PMC2898595/
https://europepmc.org/articles/PMC2898595/
Autor:
Oksana Kaidanovich-Beilin, Mustafa Khan, James R. Woodgett, Paul J. Fletcher, R. Mark Henkelman, John C. Roder, Tatiana V. Lipina, Matthijs C. van Eede, Tsuyoshi Miyakawa, Kenichi Okamoto, John W. Chambers, Satoko Hattori, Christine L. Laliberté, Keizo Takao, Katrina MacAulay, Bradley W. Doble
Publikováno v:
Molecular Brain, Vol 2, Iss 1, p 35 (2009)
Molecular Brain
Molecular Brain
Background Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded by two genes that generate two related proteins: GSK-3α and GSK-3β. Mice lacking a functional GSK-3α gene were enginee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a52c0fb92cd018ae0398bc6cfc4d01
http://www.molecularbrain.com/content/2/1/35
http://www.molecularbrain.com/content/2/1/35
Autor:
Bradley W. Doble, James R. Woodgett, Kathleen C. Woulfe, Thomas Force, Jonathan A. Epstein, Risto Kerkelä, Sarah Greytak, Jibin Zhou, Katrina MacAulay, Lisa Kockeritz, Cara Beahm, Gordon S. Huggins, Chinmay M. Trivedi
Based on extensive preclinical data, glycogen synthase kinase-3 (GSK-3) has been proposed to be a viable drug target for a wide variety of disease states, ranging from diabetes to bipolar disorder. Since these new drugs, which will be more powerful G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da305963d811e9887932e2a63570b1f
https://europepmc.org/articles/PMC2556242/
https://europepmc.org/articles/PMC2556242/
Autor:
Katrina MacAulay, James R. Woodgett
Publikováno v:
Expert opinion on therapeutic targets. 12(10)
Background: In spite of its rather specific name, glycogen synthase kinase-3 (GSK-3) is an eclectic cellular regulator that modulates an array of processes from nuclear transcription, to neurological functions and metabolism. The enzyme is also a foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6b905ab4d5d6a6d2e0b337d27b7bc6
https://pubmed.ncbi.nlm.nih.gov/18781825
https://pubmed.ncbi.nlm.nih.gov/18781825
Publikováno v:
The Journal of biological chemistry. 282(27)
Mammalian nutrient sensors are novel targets for therapeutic intervention in disease states such as insulin resistance and muscle wasting; however, the proteins responsible for this important task are largely uncharacterized. To address this issue we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a30542dba08cb234e3d02c0c5bb626
https://pubmed.ncbi.nlm.nih.gov/17488712
https://pubmed.ncbi.nlm.nih.gov/17488712
Autor:
Stephen A. Smith, Anne S. Blair, Katrina MacAulay, Eric Hajduch, Harinder S. Hundal, Matthew P. Coghlan
Publikováno v:
European journal of biochemistry. 270(18)
Glycogen synthase kinase 3 (GSK3) is inactivated by insulin and lithium and, like insulin, Li also activates glycogen synthase (GS) via inhibition of GSK3. Li also mimics insulin's ability to stimulate glucose transport (GT), an observation that has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb424a78b7027ed178310786ac10ea1
https://pubmed.ncbi.nlm.nih.gov/12950267
https://pubmed.ncbi.nlm.nih.gov/12950267