Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease

Autor: Catherine J. Mummery, Anne Börjesson-Hanson, Daniel J. Blackburn, Everard G. B. Vijverberg, Peter Paul De Deyn, Simon Ducharme, Michael Jonsson, Anja Schneider, Juha O. Rinne, Albert C. Ludolph, Ralf Bodenschatz, Holly Kordasiewicz, Eric E. Swayze, Bethany Fitzsimmons, Laurence Mignon, Katrina M. Moore, Chris Yun, Tiffany Baumann, Dan Li, Daniel A. Norris, Rebecca Crean, Danielle L. Graham, Ellen Huang, Elena Ratti, C. Frank Bennett, Candice Junge, Roger M. Lane

Publikováno v: Nature medicine 29(6), 1437-1447 (2023). doi:10.1038/s41591-023-02326-3
Mummery, C J, Börjesson-Hanson, A, Blackburn, D J, Vijverberg, E G B, de Deyn, P P, Ducharme, S, Jonsson, M, Schneider, A, Rinne, J O, Ludolph, A C, Bodenschatz, R, Kordasiewicz, H, Swayze, E E, Fitzsimmons, B, Mignon, L, Moore, K M, Yun, C, Baumann, T, Li, D, Norris, D A, Crean, R, Graham, D L, Huang, E, Ratti, E, Bennett, C F, Junge, C & Lane, R M 2023, ' Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease : a phase 1b, randomized, placebo-controlled trial ', Nature Medicine, vol. 29, no. 6, pp. 1437-1447 . https://doi.org/10.1038/s41591-023-02326-3
Nature Medicine. Nature Publishing Group
Nature Medicine, 29, 1437-1447. Nature Publishing Group

Tau plays a key role in Alzheimer’s disease (AD) pathophysiology, and accumulating evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT expression with a tau-targeting antisense oligonucleotide (MAPTRx) and reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4826e86379fe0686cd40f5d60108ba
https://doi.org/10.1038/s41591-023-02326-3

Altered Time Awareness in Dementia

Autor: Maï-Carmen Requena-Komuro, Charles R. Marshall, Rebecca L. Bond, Lucy L. Russell, Caroline Greaves, Katrina M. Moore, Jennifer L. Agustus, Elia Benhamou, Harri Sivasathiaseelan, Chris J. D. Hardy, Jonathan D. Rohrer, Jason D. Warren

Publikováno v: Frontiers in Neurology, Vol 11 (2020)

Our awareness of time, specifically of longer intervals spanning hours, days, months, and years, is critical for ensuring our sense of self-continuity. Disrupted time awareness over such intervals is a clinical feature in a number of frontotemporal d

Externí odkaz: https://doaj.org/article/c4209ced52a0419db5b06f014d24df76

White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study

Autor: Carole H. Sudre, Martina Bocchetta, Carolin Heller, Rhian Convery, Mollie Neason, Katrina M. Moore, David M. Cash, David L. Thomas, Ione O.C. Woollacott, Martha Foiani, Amanda Heslegrave, Rachelle Shafei, Caroline Greaves, John van Swieten, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Jr, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonça, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris Butler, Alex Gerhard, Johannes Levin, Adrian Danek, Giovanni B. Frisoni, Sandro Sorbi, Markus Otto, Henrik Zetterberg, Sebastien Ourselin, M. Jorge Cardoso, Jonathan D. Rohrer

Publikováno v: NeuroImage: Clinical, Vol 24, Iss , Pp - (2019)

Frontotemporal dementia (FTD) is a heterogeneous group of neurodegenerative disorders with both sporadic and genetic forms. Mutations in the progranulin gene (GRN) are a common cause of genetic FTD, causing either a behavioural presentation or, less

Externí odkaz: https://doaj.org/article/b08168152a4e4c0a9f0049681ce3c06c

Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes

Autor: Matthis Synofzik, Alexandre de Mendonça, Giovanni B. Frisoni, Maura Malpetti, Fermin Moreno, Christopher C Butler, Roberta Ghidoni, Daniela Galimberti, Rik Vandenberghe, Elizabeth Finger, Isabel Santana, Alexander Gerhard, Georgia Peakman, Emily Todd, Carolin Heller, Jonathan D. Rohrer, Katrina M. Moore, Kamen A. Tsvetanov, Rhian S Convery, P. Simon Jones, Johannes Levin, James B. Rowe, Caroline Graff, Markus Otto, Barbara Borroni, Raquel Sánchez-Valle, Sandro Sorbi, Fabrizio Tagliavini, John C. van Swieten, Maria Carmela Tartaglia, Rogier A. Kievit, Simon Ducharme, Robert Laforce, Mario Masellis, Timothy Rittman, Adrian Danek, David M. Cash, Martina Bocchetta

Publikováno v: Alzheimer's & Dementia
Alzheimer's and dementia 17(6), 969-983 (2021). doi:10.1002/alz.12252
Alzheimer's and Dementia, 17(6), 969-983. Elsevier Inc.
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Alzheimer's & Dementia, 17, 6, pp. 969-983
Alzheimer's & Dementia, 17, 969-983

© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and repro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882e8461def736551290e1e5d455cf11
https://doi.org/10.1002/alz.12252

Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort

Autor: Rachelle Shafei, Benjamin Bender, Jackie M. Poos, Maria Carmela Tartaglia, Janne M. Papma, Lieke H.H. Meeter, Isabel Santana, Christen Shoesmith, Mikel Tainta, Simon Mead, Albert Lladó, Alazne Gabilondo, Emanuela Rotondo, Alexander Gerhard, Simon Ducharme, Myriam Barandiaran, Mario Masellis, Caroline V. Greaves, Jaume Olives, Rita Guerreiro, Andrea Arighi, Diana Duro NPsych, Sara Mitchell, Roberto Gasparotti, Mathieu Vandenbulcke, Tobias Langheinrich, Thomas E. Cope, Martina Bocchetta, Robart Bartha, Daid Tang-Wai, Jessica L. Panman, Maria Rosário Almeida, Christopher C Butler, Rose Bruffaerts, Núria Bargalló, Pietro Tiraboschi, Beatriz Santiago, Elisabeth Wlasich, Philip Vandamme, Giorgio Giaccone, Sergi Borrego-Écija, Sonja Schönecker, Robert Laforce, Paola Caroppo, Katrina M. Moore, Ione O.C. Woollacott, Maria de Arriba, Veronica Redaelli, Rick van Minkelen, Jorge Villanua, Sónia Afonso, Matthis Synofzik, Nick C. Fox, Jennifer M. Nicholas, David L. Thomas, James B. Rowe, Carlo Wilke, Miren Zulaica, Pedro Rosa-Neto, Jonathan D. Rohrer, Elizabeth Finger, Carolyn Timberlake, C. Ferreira, David M. Cash, Timothy Rittman, Alessandro Padovani, Barbara Borroni, Ricardo Taipa, John C. van Swieten, Sandra V. Loosli, Begoña Indakoetxea, Daniela Galimberti, Sandra E. Black, Ana Gorostidi, Vesna Jelic, Catharina Prix, Ron Keren, Y.A.L. Pijnenburg, Michele Veldsman, Rosa Rademakers, Adrian Danek, Zigor Diaz, Miguel Tábuas-Pereira, Johannes Levin, Raquel Sánchez-Valle, Jose Bras, Rhian S Convery, Silvana Archetti, Markus Otto, Miguel Castelo-Branco, Rik Vandenberghe, Anna Antonell, Fabrizio Tagliavini, Sarah Anderl-Straub, Giuseppe Di Fede, Martin N. Rossor, Carolina Maruta MPsych, Enrico Premi, Giorgio G. Fumagalli, Sara Prioni, Cristina Muscio, Maria João Leitão, Lucy L. Russell, Håkan Thonberg, Ana Verdelho, Gabriel Miltenberger, Ekaterina Rogaeva, Giacomina Rossi, Linn Öijerstedt, Christin Andersson, Caroline Graff, Serge Gauthier, Maura Cosseddu MPsych, Carolin Heller, Stefano Gazzina, Jason D. Warren, Chiara Fenoglio, Tobias Hoegen, Elio Scarpini, Morris Freedman, Fermin Moreno, Mircea Balasa, Lize C. Jiskoot, Alexandre de Mendonça, Paul Thompson, Elisa Semler, Hans-Otto Karnarth

Publikováno v: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Cortex 133, 384-398 (2020). doi:10.1016/j.cortex.2020.08.023
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Genetic FTD Initiative (GENFI) 2020, ' Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort ', Cortex, vol. 133, pp. 384-398 . https://doi.org/10.1016/j.cortex.2020.08.023
Cortex, 133, 384-398. Masson SpA
Russell, L L, Greaves, C V, Bocchetta, M, Nicholas, J, Convery, R S, Moore, K, Cash, D M, van Swieten, J, Jiskoot, L, Moreno, F, Sanchez-Valle, R, Borroni, B, Laforce, R, Masellis, M, Tartaglia, M C, Graff, C, Rotondo, E, Galimberti, D, Rowe, J B, Finger, E, Synofzik, M, Vandenberghe, R, de Mendonça, A, Tagliavini, F, Santana, I, Ducharme, S, Butler, C, Gerhard, A, Levin, J, Danek, A, Otto, M, Warren, J D, Rohrer, J D, Rossor, M N, Fox, N C, Woollacott, I O C, Shafei, R, Heller, C, Guerreiro, R, Bras, J, Thomas, D L, Mead, S, Meeter, L, Panman, J, Papma, J, Poos, J, van Minkelen, R, Pijnenburg, Y, Barandiaran, M, Indakoetxea, B, Gabilondo, A, Tainta, M, de Arriba, M, Gorostidi, A, Zulaica, M, Villanua, J, Diaz, Z, Borrego-Ecija, S, Olives, J, Lladó, A, Balasa, M, Antonell, A, Bargallo, N, Premi, E, Cosseddu MPsych, M, Gazzina, S, Padovani, A, Gasparotti, R, Archetti, S, Black, S, Mitchell, S, Rogaeva, E, Freedman, M, Keren, R, Tang-Wai, D, Öijerstedt, L, Andersson, C, Jelic, V, Thonberg, H, Arighi, A, Fenoglio, C, Scarpini, E, Fumagalli, G, Cope, T, Timberlake, C, Rittman, T, Shoesmith, C, Bartha, R, Rademakers, R, Wilke, C, Karnarth, H-O, Bender, B, Bruffaerts, R, Vandamme, P, Vandenbulcke, M, Ferreira, C B, Miltenberger, G, Maruta MPsych, C, Verdelho, A, Afonso, S N, Taipa, R, Caroppo, P, di Fede, G, Giaccone, G, Muscio, C, Prioni, S, Redaelli, V, Rossi, G, Tiraboschi, P, Duro NPsych, D, Almeida, M R, Castelo-Branco, M, Leitão, M J, Tabuas-Pereira, M, Santiago, B, Gauthier, S, Rosa-Neto, P, Veldsman, M, Thompson, P, Langheinrich, T, Prix, C, Hoegen, T, Wlasich, E, Loosli, S, Schonecker, S, the Genetic FTD Initiative, GENFI, Semler, E & Anderl-Straub, S 2020, ' Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort ', Cortex, vol. 133, pp. 384-398 . https://doi.org/10.1016/j.cortex.2020.08.023
Medical Biophysics Publications

© 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
A key symptom of frontotemporal dementia (FTD) is difficulty interacting socially with others

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f473ba7ad713c07f0bee456df92fa2
http://europepmc.org/articles/PMC7754789