Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Katrina G. Claw"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract While significant strides have been made in understanding pharmacogenetics (PGx) and gene-drug interactions, there remains limited characterization of population-level PGx variation. This study aims to comprehensively profile global star all
Externí odkaz:
https://doaj.org/article/938603cc439748ee83b968d4a86379d9
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-5 (2024)
Innovative pharmacogenomic approaches (genetic variation related to medication response) are needed to reduce disease and disparities in Indigenous communities. We support community-based pharmacogenomics research, inclusive of Indigenous values and
Externí odkaz:
https://doaj.org/article/593ed86712c142a6a5b9eba8eb3065f3
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/be1f62d6b19e49dd87f1e4e6d44093b5
Autor:
Ahmed El‐Boraie, Julie‐Anne Tanner, Andy Z.X. Zhu, Katrina G. Claw, Bhagwat Prasad, Erin G. Schuetz, Kenneth E. Thummel, Koya Fukunaga, Taisei Mushiroda, Michiaki Kubo, Neal L. Benowitz, Caryn Lerman, Rachel F. Tyndale
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 204-220 (2022)
Abstract CYP2A6 activity, phenotyped by the nicotine metabolite ratio (NMR), is a predictor of several smoking behaviors, including cessation and smoking‐related disease risk. The heritability of the NMR is 60–80%, yet weighted genetic risk score
Externí odkaz:
https://doaj.org/article/227fec3dc8d24dc2934491cf383a5b28
Autor:
Krista R. Schaefer, Jaedon P. Avey, Michael R. Todd, Julie A. Beans, Denise A. Dillard, Laura M. Shireman, Timothy A. Thornton, Rachel F. Tyndale, Kenneth E. Thummel, Renee F. Robinson, Katrina G. Claw
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 6, Pp 2474-2486 (2021)
Abstract Prevalence of smoking is higher in Alaska Native and American Indian (ANAI) populations living in Alaska than the general US population. Genetic factors contribute to smoking and cessation rates. The objective of this study was to compare CY
Externí odkaz:
https://doaj.org/article/6b432934769e459884438c5771c4f6b3
Autor:
Alison E. Fohner, Rachel Dalton, Kasse Skagen, Konner Jackson, Katrina G. Claw, Scarlett E. Hopkins, Renee Robinson, Burhan A. Khan, Bhagwat Prasad, Erin G. Schuetz, Deborah A. Nickerson, Timothy A. Thornton, Denise A. Dillard, Bert B. Boyer, Kenneth E. Thummel, Erica L. Woodahl
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 4, Pp 1292-1302 (2021)
Abstract The frequencies of genetic variants in the CYP3A4 and CYP3A5 genes differ greatly across global populations, leading to profound differences in the metabolic activity of these enzymes and resulting drug metabolism rates, with important conse
Externí odkaz:
https://doaj.org/article/18c815b78eaf46c482f67ddc2280dfe6
Autor:
Rachel Dalton, Seung‐been Lee, Katrina G. Claw, Bhagwat Prasad, Brian R. Phillips, Danny D. Shen, Lai Hong Wong, Mitch Fade, Matthew G. McDonald, Maitreya J. Dunham, Douglas M. Fowler, Allan E. Rettie, Erin Schuetz, Timothy A. Thornton, Deborah A. Nickerson, Andrea Gaedigk, Kenneth E. Thummel, Erica L. Woodahl
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 1, Pp 147-156 (2020)
The cytochrome P450 2D6 (CYP2D6) gene locus is challenging to accurately genotype due to numerous single nucleotide variants and complex structural variation. Our goal was to determine whether the CYP2D6 genotype‐phenotype correlation is improved w
Externí odkaz:
https://doaj.org/article/16a9484280914410be57114d167f3ce5
Autor:
Katrina G. Claw, Nicolas Dundas, Michael S. Parrish, Rene L. Begay, Travis L. Teller, Nanibaa’ A. Garrison, Franklin Sage
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The Navajo Nation placed a moratorium on genetic research studies in 2002, in part due to concerns about historical distrust, exploitation, limited expertise and resources, and the lack of a genetics policy. Navajo tribal leaders, scientists, and pol
Externí odkaz:
https://doaj.org/article/4329be6a3b7f4379aab91f4d552af5c4
Autor:
Katrina G. Claw, Matthew Z. Anderson, Rene L. Begay, Krystal S. Tsosie, Keolu Fox, Nanibaa’ A. Garrison, Summer internship for INdigenous peoples in Genomics (SING) Consortium
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Indigenous peoples are still underrepresented in genetic research. Here, the authors propose an ethical framework consisting of six major principles that encourages researchers and Indigenous communities to build strong and equal partnerships to incr
Externí odkaz:
https://doaj.org/article/d06ca8cd58e6469b99e75a00699d52a3
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-17 (2018)
Abstract Background Genomic data from various organisms have been used to study how sexual selection has shaped genetic diversity in reproductive proteins, and in particular, to elucidate how mating systems may have influenced evolution at the molecu
Externí odkaz:
https://doaj.org/article/dbdf6d4eb7ed4ab1b4d9b50c270a9547