Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Katrina F. Tjhung"'
Autor:
Elena Menichelli, Bianca J. Lam, Yu Wang, Vivian S. Wang, Jennifer Shaffer, Katrina F. Tjhung, Badry Bursulaya, Truc Ngoc Nguyen, Todd Vo, Phillip B Alper, Christopher S McAllister, David H. Jones, Glen Spraggon, Pierre-Yves Michellys, John Joslin, Gerald F. Joyce, Jeff Rogers
Publikováno v:
Proceedings of the National Academy of Sciences. 119
There is growing interest in therapeutic intervention that targets disease-relevant RNAs using small molecules. While there have been some successes in RNA-targeted small-molecule discovery, a deeper understanding of structure–activity relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b63539b3423ca34c26d9030ee5bf0b
https://doi.org/10.1073/pnas.2213117119
https://doi.org/10.1073/pnas.2213117119
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
In this paper, we describe multivalent display of peptide and protein sequences typically censored from traditional N-terminal display on protein pIII of filamentous bacteriophage M13. Using site-directed mutagenesis of commercially available M13KE p
Externí odkaz:
https://doaj.org/article/9fd4c77f619e49c3abf221f143011f62
Publikováno v:
Journal of the American Chemical Society. 142(36)
Biology relies almost exclusively on homochiral building blocks to drive the processes of life. Yet cross-chiral interactions can occur between macromolecules of the opposite handedness, including a previously described polymerase ribozyme that catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b499cf50e986895f5aabc15efa0e3cf8
https://pubmed.ncbi.nlm.nih.gov/32805113
https://pubmed.ncbi.nlm.nih.gov/32805113
Publikováno v:
Proc Natl Acad Sci U S A
The RNA-based organisms from which modern life is thought to have descended would have depended on an RNA polymerase ribozyme to copy functional RNA molecules, including copying the polymerase itself. Such a polymerase must have been capable of copyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878cb53ca38a91c74df653aa35850f43
https://europepmc.org/articles/PMC7022166/
https://europepmc.org/articles/PMC7022166/
Autor:
Jian Huang, Bifang He, Andrea Rau, Ying Chou, Ratmir Derda, Katrina F. Tjhung, Nicholas J. Bennett
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports 1214 (8), . (2018)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1214), ⟨10.1038/s41598-018-19439-2⟩
Scientific Reports 1214 (8), . (2018)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1214), ⟨10.1038/s41598-018-19439-2⟩
Understanding the composition of a genetically-encoded (GE) library is instrumental to the success of ligand discovery. In this manuscript, we investigate the bias in GE-libraries of linear, macrocyclic and chemically post-translationally modified (c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b113af104ba4862d273c502a87bd3d
http://link.springer.com/article/10.1038/s41598-018-19439-2
http://link.springer.com/article/10.1038/s41598-018-19439-2
Publikováno v:
Analytical Chemistry. 86:5642-5648
Phage-based detection assays have been developed for the detection of viable bacteria for applications in clinical diagnosis, monitoring of water quality, and food safety. The majority of these assays deliver a positive readout in the form of newly g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec559eb4cfee199b27a5e18a48207cc
https://doi.org/10.1021/ac500244g
https://doi.org/10.1021/ac500244g
Publikováno v:
Lab Chip. 14:167-171
To detect antibiotic-resistant bacteria in areas remote from microbiology laboratories, we designed portable culture devices performing an analogue of the Kirby-Bauer disk diffusion test inside patterned papers embedded in tape. We quantified the ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712f6c351d12d516da596307c431b697
https://doi.org/10.1039/c3lc50887k
https://doi.org/10.1039/c3lc50887k
Autor:
Katrina F. Tjhung, Wadim L. Matochko, Ratmir Derda, Simon Ng, Mohammad R. Jafari, A. Zeberoff, Pavel I. Kitov, John S. Klassen, Lu Deng, Anastasia L. Elias
Publikováno v:
ACS Chemical Biology. 9:443-450
Light-responsive ligands are useful tools in biochemistry and cell biology because the function of these ligands can be spatially and temporally controlled. Conventional design of such ligands relies on previously available data about the structure o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3523b1386ae0f5eb55b50bdb6e82ecc
https://doi.org/10.1021/cb4006722
https://doi.org/10.1021/cb4006722
Autor:
Katrina F. Tjhung, Lu Deng, Simon Ng, Elena N. Kitova, Pavel I. Kitov, Ratmir Derda, John S. Klassen
Publikováno v:
Journal of the American Chemical Society. 138(1)
In vitro selection of chemically modified peptide libraries presented on phage, while a powerful technology, is limited to one chemical post-translational modification (cPTM) per library. We use unique combinations of redundant codons to encode cPTMs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663c8c298194def156fd8767c8fd6862
https://pubmed.ncbi.nlm.nih.gov/26683999
https://pubmed.ncbi.nlm.nih.gov/26683999
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
Frontiers in Microbiology
Frontiers in Microbiology
In this paper, we describe multivalent display of peptide and protein sequences typically censored from traditional N-terminal display on protein pIII of filamentous bacteriophage M13. Using site-directed mutagenesis of commercially available M13KE p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e95b8db36ab0701e97241eaa3a1284
https://doi.org/10.3389/fmicb.2015.00340
https://doi.org/10.3389/fmicb.2015.00340