Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Katrina Albert"'
Publikováno v:
Translational Medicine Communications, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract The incidence of brain diseases in humans is increasing as we experience a worldwide ageing of the population. Treatment for such diseases is still only symptomatic as there are almost no disease-modifying therapies available. Further, since
Externí odkaz:
https://doaj.org/article/4b757ca5c9234aa597b8a63771db4178
Autor:
Katrina Albert, Sara Kälvälä, Vili Hakosalo, Valtteri Syvänen, Patryk Krupa, Jonna Niskanen, Sanni Peltonen, Tuuli-Maria Sonninen, Šárka Lehtonen
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2649 (2022)
Alpha-synuclein’s role in diseases termed “synucleinopathies”, including Parkinson’s disease, has been well-documented. However, after over 25 years of research, we still do not fully understand the alpha-synuclein protein and its role in dis
Externí odkaz:
https://doaj.org/article/9c5dd240e943486aa5eaa48a4783bbc4
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Cerebral dopamine neurotrophic factor (CDNF) has shown therapeutic potential in rodent and non-human primate models of Parkinson’s disease by protecting the dopamine neurons from degeneration and even restoring their phenotype and function. Previou
Externí odkaz:
https://doaj.org/article/15e75cd83f96494a806ada47fcf6604c
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4334 (2021)
Induced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an organism’s somatic cells. These can then be programmed to other cell types, including neurons. Use of iPSCs in research has been two-fold as they have been us
Externí odkaz:
https://doaj.org/article/3c3679c61a9443cd9c0646dcf76398b5
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 4334, p 4334 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 4334, p 4334 (2021)
Induced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an organism’s somatic cells. These can then be programmed to other cell types, including neurons. Use of iPSCs in research has been two-fold as they have been us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1219977399246b434a7bc3733072fae9
http://europepmc.org/articles/PMC8122303
http://europepmc.org/articles/PMC8122303
Autor:
Mikko Airavaara, Ilmari Parkkinen, Julia Konovalova, Andrii Domanskyi, Piotr Chmielarz, Katrina Albert
Publikováno v:
Current protocols in neuroscienceLITERATURE CITED. 91(1)
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by motor symptoms such as tremor, slowness of movement, rigidity, and postural instability, as well as non-motor features like sleep disturbances, loss of ability to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae03c0e5cbe471857136bc9889ada0e2
https://pubmed.ncbi.nlm.nih.gov/32049438
https://pubmed.ncbi.nlm.nih.gov/32049438
Publikováno v:
Experimental Brain Research. 235:2189-2202
Proteinaceous inclusions, called Lewy bodies, are used as a pathological hallmark for Parkinson's disease (PD). Lewy bodies contain insoluble alpha-synuclein (aSyn) and many other ubiquitinated proteins, suggesting a role for protein degradation syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c091d44f8ab70a3d123506d7eedd3b99
https://doi.org/10.1007/s00221-017-4962-z
https://doi.org/10.1007/s00221-017-4962-z
Autor:
Katrina Albert, Irena Hlushchuk, Piotr Chmielarz, Laura Bandres, Andrii Domanskyi, Mikko Airavaara, Julia Konovalova, Anne Panhelainen, Kelvin C. Luk, Safak Er
Neurodegenerative diseases are associated with proteostasis disturbances and accumulation of fibrillar proteins into insoluble aggregates. Progressive age-related degeneration of dopamine neurons is a primary cause of motor dysfunctions in Parkinson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636efd6ead21b4c086021fd7284dc316
Autor:
Mikko Airavaara, Katrina Albert
Publikováno v:
Croatian Medical Journal
Volume 60
Issue 2
Volume 60
Issue 2
Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) are proteins that have received increasing attention in the last decades. Although they are called neurotrophic factors they are drastically d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c17a1673dcfe46968d68b87f194dd67
http://hdl.handle.net/10138/304516
http://hdl.handle.net/10138/304516
Autor:
Raimo K. Tuominen, Christopher T. Richie, Andrii Domanskyi, Mikko Airavaara, Brandon K. Harvey, Merja H. Voutilainen, Katrina Albert, T. Petteri Piepponen, Sari Ahola
Publikováno v:
Journal of Neuroscience Research.
Adeno-associated virus (AAV) vector-mediated delivery of human α-synuclein (α-syn) gene in rat substantia nigra (SN) results in increased expression of α-syn protein in the SN and striatum which can progressively degenerate dopaminergic neurons. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1c416f1e52fb855da2b36d16e2ba7a
https://doi.org/10.1002/jnr.24363
https://doi.org/10.1002/jnr.24363