Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Katrina A Lythgoe"'
Autor:
Helen R Fryer, Tanya Golubchik, Matthew Hall, Christophe Fraser, Robert Hinch, Luca Ferretti, Laura Thomson, Anel Nurtay, Lorenzo Pellis, Thomas House, George MacIntyre-Cockett, Amy Trebes, David Buck, Paolo Piazza, Angie Green, Lorne J Lonie, Darren Smith, Matthew Bashton, Matthew Crown, Andrew Nelson, Clare M McCann, Mohammed Adnan Tariq, Claire J Elstob, Rui Nunes Dos Santos, Zack Richards, Xin Xhang, Joseph Hawley, Mark R Lee, Priscilla Carrillo-Barragan, Isobel Chapman, Sarah Harthern-Flint, COVID-19 Genomics UK (COG-UK) consortium, David Bonsall, Katrina A Lythgoe
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011706 (2023)
[This corrects the article DOI: 10.1371/journal.ppat.1011461.].
Externí odkaz:
https://doaj.org/article/34a741634d014981b3874599a314d832
Autor:
Helen R Fryer, Tanya Golubchik, Matthew Hall, Christophe Fraser, Robert Hinch, Luca Ferretti, Laura Thomson, Anel Nurtay, Lorenzo Pellis, Thomas House, George MacIntyre-Cockett, Amy Trebes, David Buck, Paolo Piazza, Angie Green, Lorne J Lonie, Darren Smith, Matthew Bashton, Matthew Crown, Andrew Nelson, Clare M McCann, Mohammed Adnan Tariq, Claire J Elstob, Rui Nunes Dos Santos, Zack Richards, Xin Xhang, Joseph Hawley, Mark R Lee, Priscilla Carrillo-Barragan, Isobel Chapman, Sarah Harthern-Flint, COVID-19 Genomics UK (COG-UK) consortium, David Bonsall, Katrina A Lythgoe
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011461 (2023)
In this study, we evaluated the impact of viral variant, in addition to other variables, on within-host viral burden, by analysing cycle threshold (Ct) values derived from nose and throat swabs, collected as part of the UK COVID-19 Infection Survey.
Externí odkaz:
https://doaj.org/article/88e48725cc0d4fceb3aa9902b74fd193
Autor:
Christopher E Overton, Lorenzo Pellis, Helena B Stage, Francesca Scarabel, Joshua Burton, Christophe Fraser, Ian Hall, Thomas A House, Chris Jewell, Anel Nurtay, Filippo Pagani, Katrina A Lythgoe
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 9, p e1010406 (2022)
The first year of the COVID-19 pandemic put considerable strain on healthcare systems worldwide. In order to predict the effect of the local epidemic on hospital capacity in England, we used a variety of data streams to inform the construction and pa
Externí odkaz:
https://doaj.org/article/14254f9add4d4613988bea8a1292cbaf
Autor:
Christopher J R Illingworth, Jayna Raghwani, David Serwadda, Nelson K Sewankambo, Merlin L Robb, Michael A Eller, Andrew R Redd, Thomas C Quinn, Katrina A Lythgoe
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008171 (2020)
In the absence of effective antiviral therapy, HIV-1 evolves in response to the within-host environment, of which the immune system is an important aspect. During the earliest stages of infection, this process of evolution is very rapid, driven by a
Externí odkaz:
https://doaj.org/article/237886b505ae4ec4aa2c15eb448850d5
Autor:
Jayna Raghwani, Andrew D Redd, Andrew F Longosz, Chieh-Hsi Wu, David Serwadda, Craig Martens, Joseph Kagaayi, Nelson Sewankambo, Stephen F Porcella, Mary K Grabowski, Thomas C Quinn, Michael A Eller, Leigh Anne Eller, Fred Wabwire-Mangen, Merlin L Robb, Christophe Fraser, Katrina A Lythgoe
Publikováno v:
PLoS Pathogens, Vol 14, Iss 7, p e1007167 (2018)
HIV-1 undergoes multiple rounds of error-prone replication between transmission events, resulting in diverse viral populations within and among individuals. In addition, the virus experiences different selective pressures at multiple levels: during t
Externí odkaz:
https://doaj.org/article/29c5ad4c1dc040449a5e102cec4b6633
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 1, p e1005228 (2017)
The existence of long-lived reservoirs of latently infected CD4+ T cells is the major barrier to curing HIV, and has been extensively studied in this light. However, the effect of these reservoirs on the evolutionary dynamics of the virus has receive
Externí odkaz:
https://doaj.org/article/fff8be3f76854f6da543509803233a0e
Autor:
François Blanquart, Mary Kate Grabowski, Joshua Herbeck, Fred Nalugoda, David Serwadda, Michael A Eller, Merlin L Robb, Ronald Gray, Godfrey Kigozi, Oliver Laeyendecker, Katrina A Lythgoe, Gertrude Nakigozi, Thomas C Quinn, Steven J Reynolds, Maria J Wawer, Christophe Fraser
Publikováno v:
eLife, Vol 5 (2016)
Evolutionary theory hypothesizes that intermediate virulence maximizes pathogen fitness as a result of a trade-off between virulence and transmission, but empirical evidence remains scarce. We bridge this gap using data from a large and long-standing
Externí odkaz:
https://doaj.org/article/b9bd1a3349ac4d3a8a65f30215f2f85f
Publikováno v:
PLoS Biology, Vol 14, Iss 10, p e1002567 (2016)
The viral population of HIV-1, like many pathogens that cause systemic infection, is structured and differentiated within the body. The dynamics of cellular immune trafficking through the blood and within compartments of the body has also received wi
Externí odkaz:
https://doaj.org/article/6156fe34ac29425aa6ce6ff7adc59366
Autor:
Baisheng Li, Aiping Deng, Kuibiao Li, Yao Hu, Zhencui Li, Yaling Shi, Qianling Xiong, Zhe Liu, Qianfang Guo, Lirong Zou, Huan Zhang, Meng Zhang, Fangzhu Ouyang, Juan Su, Wenzhe Su, Jing Xu, Huifang Lin, Jing Sun, Jinju Peng, Huiming Jiang, Pingping Zhou, Ting Hu, Min Luo, Yingtao Zhang, Huanying Zheng, Jianpeng Xiao, Tao Liu, Mingkai Tan, Rongfei Che, Hanri Zeng, Zhonghua Zheng, Yushi Huang, Jianxiang Yu, Lina Yi, Jie Wu, Jingdiao Chen, Haojie Zhong, Xiaoling Deng, Min Kang, Oliver G. Pybus, Matthew Hall, Katrina A. Lythgoe, Yan Li, Jun Yuan, Jianfeng He, Jing Lu
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The SARS-CoV-2 Delta variant has spread rapidly worldwide. To provide data on its virological profile, we here report the first local transmission of Delta in mainland China. All 167 infections could be traced back to the first index case. Daily sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f16f2f42a9834b702bb1021b76f6134
https://doi.org/10.1038/s41467-022-28089-y
https://doi.org/10.1038/s41467-022-28089-y
Accurate measurement of exposure to SARS-CoV-2 in the population is crucial for understanding the dynamics of disease transmission and evaluating the impacts of interventions. However, it is particularly challenging to achieve this in the early phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ae783b010f61644414358766ee5be1a
https://doi.org/10.1101/2023.03.17.23287140
https://doi.org/10.1101/2023.03.17.23287140