Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Katrin Streckfuss-Bömeke"'
Autor:
Zaher ElBeck, Mohammad Bakhtiar Hossain, Humam Siga, Nikolay Oskolkov, Fredrik Karlsson, Julia Lindgren, Anna Walentinsson, Dominique Koppenhöfer, Rebecca Jarvis, Roland Bürli, Tanguy Jamier, Elske Franssen, Mike Firth, Andrea Degasperi, Claus Bendtsen, Robert I. Menzies, Katrin Streckfuss-Bömeke, Michael Kohlhaas, Alexander G. Nickel, Lars H. Lund, Christoph Maack, Ákos Végvári, Christer Betsholtz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract While excessive production of reactive oxygen species (ROS) is a characteristic hallmark of numerous diseases, clinical approaches that ameliorate oxidative stress have been unsuccessful. Here, utilizing multi-omics, we demonstrate that in c
Externí odkaz:
https://doaj.org/article/8cb734f3e6db454ca663dbe7df2cc0bb
Autor:
Wiebke Maurer, Sabine Rebs, Steffen Köhne, Hanna Eberl, Bernd Wollnik, Arne Zibat, Katrin Streckfuss-Bömeke
Publikováno v:
Stem Cell Research, Vol 77, Iss , Pp 103409- (2024)
Filamin C (FLNC) is a highly important actin crosslinker and multi-adaptor protein in striated skeletal and cardiac muscle. Mutations have been linked to a range of cardiomyopathy types. Here, we generated induced pluripotent stem cells (iPSC) from a
Externí odkaz:
https://doaj.org/article/ef95fefded4444bb90e7254eefffb8eb
Autor:
Nico Hartmann, Maria Knierim, Wiebke Maurer, Nataliya Dybkova, Florian Zeman, Gerd Hasenfuß, Samuel Sossalla, Katrin Streckfuss-Bömeke
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6144 (2024)
The sodium channel NaV1.8, encoded by the SCN10A gene, has recently emerged as a potential regulator of cardiac electrophysiology. We have previously shown that NaV1.8 contributes to arrhythmogenesis by inducing a persistent Na+ current (late Na+ cur
Externí odkaz:
https://doaj.org/article/dd0e8c93c3f74599afe5b14d2dc20c6a
Autor:
Hanna Eberl, Sabine Rebs, Stefanie Hoppe, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Benjamin Meder, Katrin Streckfuss-Bömeke
Publikováno v:
Stem Cell Research, Vol 74, Iss , Pp 103290- (2024)
RBM20 mutations account for 3 % of genetic cardiomypathies and manifest with high penetrance and arrhythmogenic effects. Numerous mutations in the conserved RS domain have been described as causing dilated cardiomyopathy (DCM), whereas a particular m
Externí odkaz:
https://doaj.org/article/b675b9ae2541449a9fefa3e7075b9752
Autor:
Sabine Rebs, Katrin Streckfuss-Bömeke
Publikováno v:
Frontiers in Molecular Medicine, Vol 3 (2023)
Mutations in the mitochondrial-DNA or mitochondria related nuclear-encoded-DNA lead to various multisystemic disorders collectively termed mitochondrial diseases. One in three cases of mitochondrial disease affects the heart muscle, which is called m
Externí odkaz:
https://doaj.org/article/8e0abb3b866e4bc58b9976c637a6428e
Autor:
Harsha V. Renikunta, Katina Lazarow, Yiqi Gong, Praphulla Chandra Shukla, Vanasa Nageswaran, Hector Giral, Adelheid Kratzer, Lennart Opitz, Felix B. Engel, Arash Haghikia, Sarah Costantino, Francesco Paneni, Jens Peter von Kries, Katrin Streckfuss-Bömeke, Ulf Landmesser, Philipp Jakob
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106593- (2023)
Summary: Ischemic cardiomyopathy, driven by loss of cardiomyocytes and inadequate proliferative response, persists to be a major global health problem. Using a functional high-throughput screening, we assessed differential proliferative potential of
Externí odkaz:
https://doaj.org/article/0397c180ca2842079b4aa0e59e2381c0
Autor:
Orr Shomroni, Maren Sitte, Julia Schmidt, Sabnam Parbin, Fabian Ludewig, Gökhan Yigit, Laura Cecilia Zelarayan, Katrin Streckfuss-Bömeke, Bernd Wollnik, Gabriela Salinas
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Single cell multi-omics analysis has the potential to yield a comprehensive understanding of the cellular events that underlie the basis of human diseases. The cardinal feature to access this information is the technology used for single-cel
Externí odkaz:
https://doaj.org/article/718a794a31d34de3b3335bcd025ec31d
Autor:
Jes-Niels Boeckel, Maximilian Möbius-Winkler, Marion Müller, Sabine Rebs, Nicole Eger, Laura Schoppe, Rewati Tappu, Karoline E. Kokot, Jasmin M. Kneuer, Susanne Gaul, Diana M. Bordalo, Alan Lai, Jan Haas, Mahsa Ghanbari, Philipp Drewe-Boss, Martin Liss, Hugo A. Katus, Uwe Ohler, Michael Gotthardt, Ulrich Laufs, Katrin Streckfuss-Bömeke, Benjamin Meder
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 1, Pp 129-146 (2022)
Alternative mRNA splicing is a fundamental process to increase the versatility of the genome. In humans, cardiac mRNA splicing is involved in the pathophysiology of heart failure. Mutations in the splicing factor RNA binding motif protein 20 (RBM20)
Externí odkaz:
https://doaj.org/article/1a62d499b1c84c03a1e970a9381d3d3a
Autor:
Nico Hartmann, Maria Knierim, Wiebke Maurer, Nataliya Dybkova, Gerd Hasenfuß, Samuel Sossalla, Katrin Streckfuss-Bömeke
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10189 (2023)
In heart failure and atrial fibrillation, a persistent Na+ current (INaL) exerts detrimental effects on cellular electrophysiology and can induce arrhythmias. We have recently shown that NaV1.8 contributes to arrhythmogenesis by inducing a INaL. Geno
Externí odkaz:
https://doaj.org/article/54102330e99f4e7fb713887cd8659ecc
Autor:
Philipp Bengel, Nataliya Dybkova, Petros Tirilomis, Shakil Ahmad, Nico Hartmann, Belal A. Mohamed, Miriam Celine Krekeler, Wiebke Maurer, Steffen Pabel, Maximilian Trum, Julian Mustroph, Jan Gummert, Hendrik Milting, Stefan Wagner, Senka Ljubojevic-Holzer, Karl Toischer, Lars S. Maier, Gerd Hasenfuss, Katrin Streckfuss-Bömeke, Samuel Sossalla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
In heart failure, increased CaMKII activity is decisively involved in arrhythmia formation. Here, the authors introduce the neuronal sodium channel NaV1.8 as a CaMKII downstream target as its specific knock-out reduces arrhythmias and improves surviv
Externí odkaz:
https://doaj.org/article/ba56cc69ae1140aebe506e2a3f9b30eb