Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Katrin Singer"'
Autor:
Christina Brummer, Katrin Singer, Almut Brand, Christina Bruss, Kathrin Renner, Wolfgang Herr, Tobias Pukrop, Christoph Dorn, Claus Hellerbrand, Carina Matos, Marina Kreutz
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8234 (2024)
Obesity is an emerging public health problem. Chronic low-grade inflammation is considered a major promotor of obesity-induced secondary diseases such as cardiovascular and fatty liver disease, type 2 diabetes mellitus, and several cancer entities. M
Externí odkaz:
https://doaj.org/article/fc3befb3233146e098ac9df39e21e6d6
Autor:
Peter J. Siska, Jing Jiao, Carina Matos, Katrin Singer, Raffaela S. Berger, Katja Dettmer, Peter J. Oefner, Michelle D. Cully, Zhonglin Wang, William J. QuinnIII, Kristen N. Oliff, Benjamin J. Wilkins, Lanette M. Christensen, Liqing Wang, Wayne W. Hancock, Joseph A. Baur, Matthew H. Levine, Ines Ugele, Roman Mayr, Kathrin Renner, Liang Zhou, Marina Kreutz, Ulf H. Beier
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103734- (2021)
Background: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce le
Externí odkaz:
https://doaj.org/article/707b3408191f474680381251d1043115
Autor:
Martina Neuburger, Katrin Singer
Publikováno v:
Redes, Vol 23, Iss 1, Pp 11-30 (2018)
The social and population structure of Peru is highly diverse and can only be understood via the emergence of social structures and the interdependence of socio-political processes in various spatial and temporal dimensions. The hierarchies already e
Externí odkaz:
https://doaj.org/article/1848c22e8e65436b87f94e7d11a596f5
Autor:
Kathrin Renner, Christina Bruss, Annette Schnell, Gudrun Koehl, Holger M. Becker, Matthias Fante, Ayse-Nur Menevse, Nathalie Kauer, Raquel Blazquez, Lisa Hacker, Sonja-Maria Decking, Toszka Bohn, Stephanie Faerber, Katja Evert, Lisa Aigle, Sabine Amslinger, Maria Landa, Oscar Krijgsman, Elisa A. Rozeman, Christina Brummer, Peter J. Siska, Katrin Singer, Stefanie Pektor, Matthias Miederer, Katrin Peter, Eva Gottfried, Wolfgang Herr, Ibtisam Marchiq, Jacques Pouyssegur, William R. Roush, SuFey Ong, Sarah Warren, Tobias Pukrop, Philipp Beckhove, Sven A. Lang, Tobias Bopp, Christian U. Blank, John L. Cleveland, Peter J. Oefner, Katja Dettmer, Mark Selby, Marina Kreutz
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 135-150.e9 (2019)
Summary: Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor immunosurveillance. Here, we report that melanoma patients with high expression of glycolysis-related genes show a worse progression free survival
Externí odkaz:
https://doaj.org/article/ca9683bbded745c68d1cf4f71ab912e4
Autor:
Katrin Singer, Katja Dettmer, Petra Unger, Gabriele Schönhammer, Kathrin Renner, Katrin Peter, Peter J. Siska, Mark Berneburg, Wolfgang Herr, Peter J. Oefner, Sigrid Karrer, Marina Kreutz, Elisabeth Datz
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: Melanoma and squamous cell carcinoma of the skin are characterized by an altered glucose metabolism, but little is known about metabolic changes in precancerous skin lesions such as actinic keratosis (AK). Here, we studied the central car
Externí odkaz:
https://doaj.org/article/f1da1ee8de5443b4bfe51368286c43d9
Autor:
Kathrin Renner, Anton Seilbeck, Nathalie Kauer, Ines Ugele, Peter J. Siska, Christina Brummer, Christina Bruss, Sonja-Maria Decking, Matthias Fante, Astrid Schmidt, Kathrin Hammon, Katrin Singer, Sebastian Klobuch, Simone Thomas, Eva Gottfried, Katrin Peter, Marina Kreutz
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The accelerated metabolism of tumor cells, inevitable for maintaining high proliferation rates, is an emerging target for tumor therapy. Increased glucose and lipid metabolism as well as mitochondrial activity have been shown in solid tumors but also
Externí odkaz:
https://doaj.org/article/2a068e5a9f344f869bc511d67dced0cf
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 8 (2018)
The scientific knowledge about tumor metabolism has grown at a fascinating rate in recent decades. We now know that tumors are highly active both in their metabolism of available nutrients and in the secretion of metabolic by-products. However, cance
Externí odkaz:
https://doaj.org/article/b93bfddaa3f54d13841328e715c480a9
Autor:
Ines Ugele, Zugey Elizabeth Cárdenas-Conejo, Kathrin Hammon, Monika Wehrstein, Christina Bruss, Katrin Peter, Katrin Singer, Eva Gottfried, Jakob Boesch, Peter Oefner, Katja Dettmer, Kathrin Renner, Marina Kreutz
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 3, p 742 (2019)
Mutations in isocitrate dehydrogenase (IDH) or a reduced expression of L-2-hydroxyglutarate (HG)-dehydrogenase result in accumulation of D-2-HG or L-2-HG, respectively, in tumor tissues. D-2-HG and L-2-HG have been shown to affect T-cell differentiat
Externí odkaz:
https://doaj.org/article/71614b3a027c46b482c42d297ff17421
Autor:
Jana Knop, Shingen Misaka, Katrin Singer, Eva Hoier, Fabian Müller, Hartmut Glaeser, Jörg König, Martin F Fromm
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139370 (2015)
Green tea catechins inhibit the function of organic anion transporting polypeptides (OATPs) that mediate the uptake of a diverse group of drugs and endogenous compounds into cells. The present study was aimed at investigating the effect of green tea
Externí odkaz:
https://doaj.org/article/f460229adcb7463e8895bc5aebd92d6c
Autor:
Tobias Roider, Michael Katzfuß, Carina Matos, Katrin Singer, Kathrin Renner, Peter J. Oefner, Katja Dettmer-Wilde, Wolfgang Herr, Ernst Holler, Marina Kreutz, Katrin Peter
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 12, p 2081 (2016)
Antithymocyte globulin (ATG) is used in the prevention of graft-versus-host disease during allogeneic hematopoietic stem cell transplantation. It is generally accepted that ATG mediates its immunosuppressive effect primarily via depletion of T cells.
Externí odkaz:
https://doaj.org/article/63ce90eb529845b59457dff90316f2a7