Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Katrin Schaak"'
1
Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions
Autor: Amelie V, Guitart, Theano I, Panagopoulou, Arnaud, Villacreces, Milica, Vukovic, Catarina, Sepulveda, Lewis, Allen, Roderick N, Carter, Louie N, van de Lagemaat, Marcos, Morgan, Peter, Giles, Zuzanna, Sas, Marta Vila, Gonzalez, Hannah, Lawson, Jasmin, Paris, Joy, Edwards-Hicks, Katrin, Schaak, Chithra, Subramani, Deniz, Gezer, Alejandro, Armesilla-Diaz, Jimi, Wills, Aaron, Easterbrook, David, Coman, Chi Wai Eric, So, Donal, O'Carroll, Douglas, Vernimmen, Neil P, Rodrigues, Patrick J, Pollard, Nicholas M, Morton, Andrew, Finch, Kamil R, Kranc
Publikováno v: Guitart, A V, Panagopoulou, T I, Villacreces, A, Vukovic, M, Sepulveda, C, Allen, L, Carter, R N, van de Lagemaat, L N, Morgan, M, Giles, P, Sas, Z, Gonzalez, M V, Lawson, H, Paris, J, Edwards-Hicks, J, Schaak, K, Subramani, C, Gezer, D, Armesilla-Diaz, A, Wills, J, Easterbrook, A, Coman, D, So, C W E, O'Carroll, D, Vernimmen, D, Rodrigues, N P, Pollard, P J, Morton, N M, Finch, A & Kranc, K R 2017, ' Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions ', The Journal of experimental medicine, vol. 214, no. 3, pp. 719-735 . https://doi.org/10.1084/jem.20161087
The Journal of Experimental Medicine
Guitart et al. performed an in vivo genetic dissection of the Krebs cycle enzyme fumarate hydratase (Fh1) in the hematopoietic system. Their investigations revealed multifaceted functions of Fh1 in the regulation of hematopoietic stem cell biology an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b414ecb67ecfd079f28382a9e58a2a5b
https://kclpure.kcl.ac.uk/en/publications/606e0f65-93b1-4f5f-9846-41292a145066
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2
Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance
Autor: Lewis Allen, Juan Manuel Iglesias, Deniz Gezer, Tessa L. Holyoake, Juan Bautista Menendez-Gonzalez, Alasdair Ivens, Kamil R. Kranc, Alejandro Armesilla-Diaz, Dónal O'Carroll, Annemarie E.M. Post, Milica Vukovic, Katrin Schaak, Peter J. Ratcliffe, Theano I. Panagopoulou, Chithra Subramani, Arnaud Villacreces, Catarina Sepulveda, Amelie V. Guitart, Andrew J. Wood, Eoghan O'Duibhir, Fokion Glykofrydis, Chi Wai Eric So
Publikováno v: Vukovic, M, Guitart, A V, Sepulveda, C, Villacreces, A, O'Duibhir, E, Panagopoulou, T I, Ivens, A, Menendez-Gonzalez, J, Iglesias, J M, Allen, L, Glykofrydis, F, Subramani, C, Armesilla-Diaz, A, Post, A E M, Schaak, K, Gezer, D, So, C W E, Holyoake, T L, Wood, A, O'Carroll, D, Ratcliffe, P J & Kranc, K R 2015, ' Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance ', Journal of Experimental Medicine, vol. 212, no. 13, pp. 2223-2234 . https://doi.org/10.1084/jem.20150452
Leukemogenesis occurs under hypoxic conditions within the bone marrow (BM). Knockdown of key mediators of cellular responses to hypoxia with shRNA, namely hypoxia-inducible factor-1α (HIF-1α) or HIF-2α, in human acute myeloid leukemia (AML) sample
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f9e6327f3838ae1e0e75347115e010
https://hdl.handle.net/20.500.11820/353bbf24-4e43-44e8-9492-c0c50665074c
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3
Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome
Autor: Ulrike Zabel, Thomas Wieland, Martin J. Lohse, Fabio R. Faucz, Annalisa Vetro, Andrea Osswald, Guillaume Assié, Cristina L. Ronchi, Thomas Schwarzmayr, Susanne Diener, Caroline Kisker, Bruno Allolio, Tim M. Strom, Silviu Sbiera, Olivia Barreau, Martin Reincke, Delphine Vezzosi, Felix Beuschlein, Jérôme Bertherat, Orsetta Zuffardi, Antonella Forlino, Thomas Meitinger, Martin Fassnacht, Katrin Schaak, Eva Szarek, Constantine A. Stratakis, Anett Schmittfull, Paraskevi Salpea, Davide Calebiro, Marthe Rizk-Rabin
Publikováno v: New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2014, 370 (11), pp.1019-1028. ⟨10.1056/NEJMoa1310359⟩
New England Journal of Medicine, Massachusetts Medical Society, 2014, 370 (11), pp.1019-28. 〈10.1056/NEJMoa1310359〉
New England Journal of Medicine, Massachusetts Medical Society, 2014, 370 (11), pp.1019-28. ⟨10.1056/NEJMoa1310359⟩
New England Journal of Medicine, 2014, 370 (11), pp.1019-28. ⟨10.1056/NEJMoa1310359⟩
International audience; BACKGROUND: Corticotropin-independent Cushing's syndrome is caused by tumors or hyperplasia of the adrenal cortex. The molecular pathogenesis of cortisol-producing adrenal adenomas is not well understood. METHODS: We performed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefd92b522a983c9b7b564fa4686b280
https://hal.archives-ouvertes.fr/hal-02376099
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6
TNFR1 Signaling and IFN-γ Signaling Determine whether T Cells Induce Tumor Dormancy or Promote Multistage Carcinogenesis
Autor: Katrin Schaak, Markus Schwaiger, Bernd J. Pichler, Christian Sander, Reinhard Mailhammer, Thomas Wieder, Ralph Mocikat, Wolfgang Weber, Manfred Kneilling, Irmgard Förster, Kamran Ghoreschi, Amir S. Yazdi, Ralph Huss, Heidi Braumüller, Martin Röcken, Nele Müller-Hermelink, Roland Haubner
Publikováno v: Cancer Cell. (6):507-518
Immune responses may arrest tumor growth by inducing tumor dormancy. The mechanisms leading to either tumor dormancy or promotion of multistage carcinogenesis by adaptive immunity are poorly characterized. Analyzing T antigen (Tag)-induced multistage
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b197d5b7a6634bd44ed8efaf868d76
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