Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Katrin M. Kirschbaum"'
Autor:
Ulrich Schmitt, Manisha Kusch-Poddar, Heike Gutmann, Christoph Hiemke, Katrin M. Kirschbaum, Jürgen Drewe, Birk Poller
Publikováno v:
Pharmacology Biochemistry and Behavior. 102:312-320
Background P-glycoprotein (P-gp), an efflux transporter of the blood–brain barrier, limits the access of multiple xenobiotics to the central nervous system (CNS). Thus drug-dependent inhibition, induction or genetic variation of P-gp impacts drug t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655ce8c96e0930c01fc76809e64aed62
https://doi.org/10.1016/j.pbb.2012.04.002
https://doi.org/10.1016/j.pbb.2012.04.002
Publikováno v:
Forensic Science International. 215:60-63
A preliminary initial enzyme-linked immunosorbent assay (LUCIO ® -Direct ELISA kit) and a preliminary DRI ® enzyme immunoassay were evaluated for drug detection in head hair with respect to lowered cutoff values recommended in Germany for the contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5a6562ecb1cde0559ed82d63be006c
https://doi.org/10.1016/j.forsciint.2011.03.030
https://doi.org/10.1016/j.forsciint.2011.03.030
Publikováno v:
Journal of Analytical Toxicology. 35:124-128
Quaternary ammonium compounds pose an analytical challenge. Mebezonium, a muscle-relaxing agent contained in veterinary euthanasia solution T61, was analyzed in body fluids, organs, and injection sites of a veterinarian by liquid chromatography-tande
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea723a9b4e93d6e3678a86d2fb2f0eaa
https://doi.org/10.1093/anatox/35.2.124
https://doi.org/10.1093/anatox/35.2.124
Autor:
Ulrich Schmitt, Manfred Uhr, Katrin M. Kirschbaum, Christian Namendorf, David Holthoewer, Claus U. Pietrzik, Christoph Hiemke
Publikováno v:
Neuropharmacology. 59:474-479
Background P-glycoprotein (P-gp), an efflux transporter localized in the blood–brain barrier, limits the access of multiple xenobiotics to the central nervous system (CNS). For the new antipsychotic aripiprazole and its active metabolite dehydroari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9444fab66eaa88fde8ae02fd0fc8466
https://doi.org/10.1016/j.neuropharm.2010.06.010
https://doi.org/10.1016/j.neuropharm.2010.06.010
Publikováno v:
Forensic Science International. 189:e37-e40
The case of a 13-month-old boy with a diagnosis of unclear unconsciousness is reported on. As the physical examination did not lead to any explanation of his condition, the administration of drugs in the context of Munchausen syndrome by proxy was su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892bccfce703e79263c162c02ede1db5
https://doi.org/10.1016/j.forsciint.2009.04.021
https://doi.org/10.1016/j.forsciint.2009.04.021
Autor:
Katja M Spreckelmeyer, Hildegard Janouschek, Katrin M. Kirschbaum, Gerhard Gründer, Anno Bröcheler, Ingo Vernaleken, Sandra Hellmann, Christian Boy, Christoph Hiemke, Frank Rösch, Christine Fellows, Wolfgang M. Schaefer, Tanja Veselinović
Publikováno v:
American Journal of Psychiatry. 165:988-995
Aripiprazole at clinically effective doses occupies some 90% of striatal dopamine 2 and 3 (D(2)/D(3)) receptors. In order to further characterize its extrastriatal and time-dependent binding characteristics, the authors conducted positron emission to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3b84ac5fc2b346e8be3293e0c0a162
https://doi.org/10.1176/appi.ajp.2008.07101574
https://doi.org/10.1176/appi.ajp.2008.07101574
Publikováno v:
Behavioural Brain Research. 188:298-303
Efflux transporters, like P-glycoprotein (P-gp), may limit the access of drugs to the brain via the blood-brain barrier. The antipsychotic drug risperidone and its active metabolite 9-hydroxyrisperidone (paliperidone) are substrates of P-gp. Motor be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6376da2f2aa808c3668d07f8f7272dd7
https://doi.org/10.1016/j.bbr.2007.11.009
https://doi.org/10.1016/j.bbr.2007.11.009
Autor:
Manfred Gerlach, Friederike Vogel, Peter Riederer, Christoph Hiemke, Katrin M. Kirschbaum, Susann Finger, R. Burger
Publikováno v:
Chromatographia. 67:321-324
An automated high performance liquid chromatography with column-switching and ultraviolet detection was developed for the analysis of risperidone and 9-hydroxyrisperidone. The method needs minimum sample preparation and is useful for the detection do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a0b74e6b1e2845bd8a2db2046794d7f
https://doi.org/10.1365/s10337-007-0506-1
https://doi.org/10.1365/s10337-007-0506-1
Autor:
Jaroslav Malevani, Katrin M. Kirschbaum, Matthias J. Müller, Markus Piel, Arian Mobascher, Christoph Hiemke, Carsten Burchardt
Publikováno v:
The World Journal of Biological Psychiatry. 9:212-218
Aripiprazole, a novel antipsychotic drug, is metabolized by CYP3A4 and CYP2D6 forming mainly its active metabolite dehydroaripiprazole. In this study, aripiprazole and dehydroaripiprazole serum levels of psychiatric patients were measured and related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7e4d1a76355cd98f09705c1c9744ca
https://doi.org/10.1080/15622970701361255
https://doi.org/10.1080/15622970701361255
Autor:
Alois Saria, Matthias J. Müller, Jaroslav Malevani, Gerald Zernig, Christoph Hiemke, Katrin M. Kirschbaum, Arian Mobascher
Publikováno v:
Clinical Chemistry. 51:1718-1721
Aripiprazole is a novel atypical antipsychotic drug for the treatment of schizophrenia and schizoaffective disorders (1)(2)(3). The drug is metabolized by the cytochrome P450 isoenzymes 3A4 and 2D6 (4). Because of high interindividual variability in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e86cc41b92e274ad0e966f54e8c796
https://doi.org/10.1373/clinchem.2005.049809
https://doi.org/10.1373/clinchem.2005.049809