Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Katrin Fundel-Clemens"'
Autor:
Diana Santacruz, Francis O Enane, Katrin Fundel-Clemens, Martin Giner, Gernot Wolf, Svenja Onstein, Christoph Klimek, Zachary Smith, Bhagya Wijayawardena, Coralie Viollet
Publikováno v:
SLAS Discovery, Vol 29, Iss 5, Pp 100169- (2024)
Externí odkaz:
https://doaj.org/article/0035d705cae7419e99370a7dd6b92582
Autor:
Diana Santacruz, Francis O Enane, Katrin Fundel-Clemens, Martin Giner, Gernot Wolf, Svenja Onstein, Christoph Klimek, Zachary Smith, Bhagya Wijayawardena, Coralie Viollet
Publikováno v:
SLAS Discovery, Vol 27, Iss 2, Pp 140-147 (2022)
Over the last decade, whole transcriptome profiling, also known as RNA-sequencing (RNA-seq), has quickly gained traction as a reliable method for unbiased assessment of gene expression. Integration of RNA-seq expression data into other omics datasets
Externí odkaz:
https://doaj.org/article/bb0e8a9732a44f15a5e8c6e0d9ca077e
Autor:
Sibel Durlanik, Katrin Fundel-Clemens, Coralie Viollet, Heinrich J. Huber, Martin Lenter, Kerstin Kitt, Stefan Pflanz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract More than 70% of colorectal, prostate, ovarian, pancreatic and breast cancer specimens show expression of CD276 (B7–H3), a potential immune checkpoint family member. Several studies have shown that high CD276 expression in cancer cells cor
Externí odkaz:
https://doaj.org/article/3514e95bf4724fdea484cf4f1f37996c
Autor:
David Lamb, Dorothy De Sousa, Karsten Quast, Katrin Fundel-Clemens, Jonas S. Erjefält, Caroline Sandén, Hans Jürgen Hoffmann, Marc Kästle, Ramona Schmid, Kevin Menden, Denis Delic
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background RORγt is a transcription factor that enables elaboration of Th17-associated cytokines (including IL-17 and IL-22) and is proposed as a pharmacological target for severe asthma. Methods IL-17 immunohistochemistry was performed in
Externí odkaz:
https://doaj.org/article/4625d57e20204c418b1d262620920965
Autor:
Jasmin Scheurer, Kerstin Kitt, Heinrich J. Huber, Katrin Fundel-Clemens, Stefan Pflanz, Klaus-Michael Debatin, Gudrun Strauss
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid progenitor cells that dampen overwhelming adaptive immune responses through multiple mechanisms and are recognized as an attractive novel immune intervention therapy f
Externí odkaz:
https://doaj.org/article/e567342ce2e94e6eae5016086044ea94
Autor:
Di Cui, Alexandra Franz, Sophie A. Fillon, Linda Jannetti, Timo Isambert, Katrin Fundel-Clemens, Heinrich J. Huber, Coralie Viollet, Alexander Ghanem, Akira Niwa, Bernd Weigle, Stefan Pflanz
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Macrophages are pivotal effectors of host immunity and regulators of tissue homeostasis. Understanding of human macrophage biology has been hampered by the lack of reliable and scalable models for cellular and genetic studies. Human induced pluripote
Externí odkaz:
https://doaj.org/article/f5997adc6e3d4ba3a1123201fae071b7
Autor:
Wolfgang P. Ruf, Axel Freischmidt, Veselin Grozdanov, Valerie Roth, Sarah J. Brockmann, Brit Mollenhauer, Dorothea Martin, Bernhard Haslinger, Katrin Fundel-Clemens, Markus Otto, Christine von Arnim, Karlheinz Holzmann, Albert C. Ludolph, Jochen H. Weishaupt, Karin M. Danzer
Publikováno v:
Cells, Vol 10, Iss 4, p 791 (2021)
Accumulating evidence suggests that microRNAs (miRNAs) are a contributing factor to neurodegenerative diseases. Although altered miRNA profiles in serum or plasma have been reported for several neurodegenerative diseases, little is known about the in
Externí odkaz:
https://doaj.org/article/808a1008cd304e32a6a70f47921e6f17
Autor:
Patrick Baum, Ramona Schmid, Carina Ittrich, Werner Rust, Katrin Fundel-Clemens, Susanne Siewert, Martin Baur, Lisa Mara, Lore Gruenbaum, Armin Heckel, Roland Eils, Roland E Kontermann, Gerald J Roth, Florian Gantner, Andreas Schnapp, John E Park, Andreas Weith, Karsten Quast, Detlev Mennerich
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14272 (2010)
A phenocopy is defined as an environmentally induced phenotype of one individual which is identical to the genotype-determined phenotype of another individual. The phenocopy phenomenon has been translated to the drug discovery process as phenotypes p
Externí odkaz:
https://doaj.org/article/7e2fb73d5ce749f599c79099e9a76b50
Autor:
Carolin K. Watson, Daniela Schloesser, Katrin Fundel-Clemens, Carmen Lerner, Svenja Gabler, Praveen Baskaran, Christian T. Wohnhaas, Stefanie Dichtl, Heinrich J. Huber, Kjetil Ask, Florian Gantner, Coralie Viollet, Matthew J. Thomas, Fidel Ramirez, Peter J. Murray, Karim C. El Kasmi
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 68:366-380
Pro-fibrotic and pro-homeostatic macrophage phenotypes remain ill-defined, both in vivo and in vitro impeding successful development of drugs that reprogram macrophages as an attractive therapeutic approach to manage fibrotic disease. The goal to of
Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis
Autor:
Daniela Schloesser, Laura Lindenthal, Julia Sauer, Kyoung-Jin Chung, Triantafyllos Chavakis, Eva Griesser, Praveen Baskaran, Ulrike Maier-Habelsberger, Katrin Fundel-Clemens, Ines Schlotthauer, Carolin Kirsten Watson, Lee Kim Swee, Frederik Igney, John Edward Park, Markus S. Huber-Lang, Matthew-James Thomas, Karim Christian El Kasmi, Peter J. Murray
Publikováno v:
The Journal of cell biology. 222(2)
Progressive accrual of senescent cells in aging and chronic diseases is associated with detrimental effects in tissue homeostasis. We found that senescent fibroblasts and epithelia were not only refractory to macrophage-mediated engulfment and remova