Výsledky vyhledávání - "Katrin Eckermann"

Dimerization propensities of Synucleins are not predictive for Synuclein aggregation

Autor: Sebastian Kügler, Mathias Bähr, Katrin Eckermann

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1852:1658-1664

Aggregation and fibril formation of human alpha-Synuclein (αS) are neuropathological hallmarks of Parkinson's disease and other synucleinopathies. The molecular mechanisms of αS aggregation and fibrillogenesis are largely unknown. Several studies s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae6360668459160b8b83a6a171f16b5
https://doi.org/10.1016/j.bbadis.2015.05.002

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LRRK2 Promotes Tau Accumulation, Aggregation and Release

Autor: Ellen Gerhardt, Patrícia Guerreiro, Mathias Bähr, Katrin Eckermann, Tomás Lopes da Fonseca, Tiago F. Outeiro

Publikováno v: Molecular Neurobiology. 53:3124-3135

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are known as the most frequent cause of familial Parkinson's disease (PD), but are also present in sporadic cases. The G2019S-LRRK2 mutation is located in the kinase domain of the protein, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a16fbd3d6d5b346dcface489fe35b11
https://doi.org/10.1007/s12035-015-9209-z

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Sumoylation of p35 Modulates p35/Cyclin-Dependent Kinase (Cdk) 5 Complex Activity

Autor: Petranka Krumova, Anja Büchner, Jochen H. Weishaupt, Mathias Bähr, Sundar Ganesan, Katrin Eckermann

Publikováno v: NeuroMolecular Medicine. 17:12-23

Cyclin-dependent kinase (Cdk) 5 is critical for central nervous system development and neuron-specific functions including neurite outgrowth as well as synaptic function and plasticity. Cdk5 activity requires association with one of the two regulator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1219b6cc438caf67797237a3eadd5344
https://doi.org/10.1007/s12017-014-8336-4

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SUMO and Parkinson’s Disease

Autor: Katrin Eckermann

Publikováno v: NeuroMolecular Medicine. 15:737-759

Parkinson's disease (PD) is one of the most common degenerative disorders of the central nervous system that produces motor and non-motor symptoms. The majority of cases are idiopathic and characterized by the presence of Lewy bodies containing fibri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c30abca20056694ae9f95d360859aaa
https://doi.org/10.1007/s12017-013-8259-5

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The Potential for β-Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

Autor: Olga Petrova, Maria-Magdalena Mocanu, Katrin Eckermann, Lepu Zhou, Eckhard Mandelkow, Eva-Maria Mandelkow, Jacek Biernat, Dagmar Drexler, Gabriele M. Rune, Kai Schönig, Hermann Bujard, Astrid Nissen, Inna Khlistunova

Publikováno v: The Journal of Neuroscience. 28:737-748

We describe two new transgenic mouse lines for studying pathological changes of Tau protein related to Alzheimer's disease. They are based on the regulatable expression of the four-repeat domain of human Tau carrying the FTDP17 (frontotemporal dement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb41d6cdb01fe69c6745a135431014e3
https://doi.org/10.1523/jneurosci.2824-07.2008

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The β-Propensity of Tau Determines Aggregation and Synaptic Loss in Inducible Mouse Models of Tauopathy

Autor: Astrid Nissen, Andreas Haemisch, Katrin Eckermann, Lepu Zhou, Eckhard Mandelkow, Jacek Biernat, Inna Khlistunova, Eva-Maria Mandelkow, Anne Hofmann, Kai Schönig, Hermann Bujard, Maria Magdalena Mocanu, Gabriele M. Rune

Publikováno v: Journal of Biological Chemistry. 282:31755-31765

Neurofibrillary lesions are characteristic for a group of human diseases, named tauopathies, which are characterized by prominent intracellular accumulations of abnormal filaments formed by the microtubule-associated protein Tau. The tauopathies are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81c3083994d7771dc848341729c85f1
https://doi.org/10.1074/jbc.m705282200

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Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

Publikováno v: Acta Neuropathologica
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Acta neuropathologica 129(5), 695-713 (2015). doi:10.1007/s00401-015-1408-1
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

Extracellular α-Synuclein has been implicated in interneuronal propagation of disease pathology in Parkinson’s Disease. How α-Synuclein is released into the extracellular space is still unclear. Here, we show that α-Synuclein is present in extra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b82696db7cb852a7ccf5bf7a094f6a
https://pubmed.ncbi.nlm.nih.gov/25778619

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Aboriginal Education in Rural Australia: A Case Study in Frustration and Hope

Autor: Anne-Katrin Eckermann

Publikováno v: Australian Journal of Education. 43:5-23

THIS paper considers patterns in Aboriginal education recorded over the past 25 years in one small country town in south west Queensland. Data from this longitudinal study are used to illustrate national patterns and trends. Discussion highlights the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96cd3e25eb507fbb53dc1690581d4e34
https://doi.org/10.1177/000494419904300102

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